Aerobic training improves NAFLD markers and insulin resistance through AMPK-PPAR-α signaling in obese mice

Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-γ and genes involved in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat diet

(2019) Fan Zheng et al.   Lipids in Health and Disease

Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation

(2019) Parvin Farzanegi et al.   European Journal of Sport Science

Effect of PPAR-gamma agonist on aerobic exercise capacity in relation to body fat distribution in men with type 2 diabetes and coronary artery disease

(2019) Marjorie Bastien et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Clinical and Economic Burden of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

(2018) Zobair M. Younossi et al.   Clinics in Liver Disease

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development

(2018) Nadia Boudaba et al.   EBioMedicine

Palmitoleic Acid Improves Metabolic Functions in Fatty Liver by PPARα-Dependent AMPK Activation

(2017) Camila O. de Souza et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Treatment of NAFLD with diet, physical activity and exercise

(2017) Manuel Romero-Gómez et al.   JOURNAL OF HEPATOLOGY

The effects of calorie-matched high-fat diet consumption on spontaneous physical activity and development of obesity

(2017) Thais Ludmilla Moretto et al.   LIFE SCIENCES

Endocrine-disrupting chemicals and fatty liver disease

(2017) Charles E. Foulds et al.   Nature Reviews Endocrinology

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acute exercise regulates adipogenic gene expression in white adipose tissue

(2016) Yanyan Shen et al.   BIOLOGY OF SPORT

Association Between Aerobic Exercise and Rosiglitazone Avoided the NAFLD and Liver Inflammation Exacerbated in PPAR-α Knockout Mice

(2016) Helena A.P. Batatinha et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice

(2015) Andreas B. Jordy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Voluntary exercise prevents colonic inflammation in high-fat diet-induced obese mice by up-regulating PPAR-γ activity

(2015) Wei-Xin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMPK Suppresses Vascular Inflammation In Vivo by Inhibiting Signal Transducer and Activator of Transcription-1

(2015) Chaoyong He et al.   DIABETES

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

(2015) Michal Pawlak et al.   JOURNAL OF HEPATOLOGY

Effect of Training Intensity on Nonalcoholic Fatty Liver Disease

(2015) JINKYUNG CHO et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Exercise training improves liver steatosis in mice

(2015) Sheril Alex et al.   Nutrition & Metabolism

Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting

(2014) Qilin Gu et al.   HEPATOLOGY

Pre-endurance training prevents acute alcoholic liver injury in rats through the regulation of damaged mitochondria accumulation and mitophagy balance

(2014) Guo-dong Ma et al.   Hepatology International

Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

(2014) D. Sag et al.   JOURNAL OF IMMUNOLOGY

Establishment of a General NAFLD Scoring System for Rodent Models and Comparison to Human Liver Pathology

(2014) Wen Liang et al.   PLoS One

The immunomodulating role of exercise in metabolic disease

(2014) Graeme I. Lancaster et al.   TRENDS IN IMMUNOLOGY

Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 randomized trial)

(2013) Elisabetta Bacchi et al.   HEPATOLOGY

Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2013) Bart Staels et al.   HEPATOLOGY

Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells

(2013) Eva Morán-Salvador et al.   JOURNAL OF HEPATOLOGY

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

AMP-activated protein kinase: new regulation, new roles?

(2012) David Carling et al.   BIOCHEMICAL JOURNAL

Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in mice

(2012) Noriaki Kawanishi et al.   BRAIN BEHAVIOR AND IMMUNITY

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity

(2012) Martin Friedrichsen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

AMPK activation enhances PPARα activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway

(2011) Rongsen Meng et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts

(2011) Eva Morán-Salvador et al.   FASEB JOURNAL

Exercise-associated generation of PPARγ ligands activates PPARγ signaling events and upregulates genes related to lipid metabolism

(2011) A. W. Thomas et al.   JOURNAL OF APPLIED PHYSIOLOGY

Adipogenesis at a glance

(2011) C. E. Lowe et al.   JOURNAL OF CELL SCIENCE

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

(2011) Sandra Galic et al.   JOURNAL OF CLINICAL INVESTIGATION

Swimming training beneficial effects in a mice model of nonalcoholic fatty liver disease

(2010) Alini Schultz et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss

(2009) S. Balducci et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Peroxisome proliferator-activated receptor gamma (PPARγ): Is the genomic activity the only answer?

(2009) Michaela Luconi et al.   STEROIDS