Puerarin protects against high‐fat high‐sucrose diet‐induced non‐alcoholic fatty liver disease by modulating PARP‐1/PI3K/AKT signaling pathway and facilitating mitochondrial homeostasis

Inhibition of poly(ADP-ribose) polymerase-1 alters expression of mitochondria-related genes in PC12 cells: relevance to mitochondrial homeostasis in neurodegenerative disorders

(2018) Grzegorz A. Czapski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of Rac1 ameliorates neuronal oxidative stress damage via reducing Bcl-2/Rac1 complex formation in mitochondria through PI3K/Akt/mTOR pathway

(2018) Yundan Pan et al.   EXPERIMENTAL NEUROLOGY

IRE1α Aggravates Ischemia Reperfusion Injury of Fatty Liver by Regulating Phenotypic Transformation of Kupffer Cells

(2018) Faji Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria in non-alcoholic fatty liver disease

(2018) Inês C.M. Simões et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

LAMP3 regulates hepatic lipid metabolism through activating PI3K/Akt pathway

(2018) Xiaoyu Liao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genipin ameliorates diet-induced obesity via promoting lipid mobilization and browning of white adipose tissue in rats

(2018) Lili Guan et al.   PHYTOTHERAPY RESEARCH

Dehydroleucodine inhibits mitotic clonal expansion during adipogenesis through cell cycle arrest

(2018) S. Abood et al.   PHYTOTHERAPY RESEARCH

Puerarin inhibits TRPM3/miR-204 to promote MC3T3-E1 cells proliferation, differentiation and mineralization

(2018) Xiangwei Zeng et al.   PHYTOTHERAPY RESEARCH

De novo NAD+ synthesis enhances mitochondrial function and improves health

(2018) Elena Katsyuba et al.   NATURE

Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: Role of disturbed lipid homeostasis and increased oxidative stress

(2017) Youngshim Choi et al.   FOOD AND CHEMICAL TOXICOLOGY

Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases

(2017) Leon A Adams et al.   GUT

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

(2017) Karim Gariani et al.   JOURNAL OF HEPATOLOGY

PARP1-mediated PPARα poly(ADP-ribosyl)ation suppresses fatty acid oxidation in non-alcoholic fatty liver disease

(2017) Kun Huang et al.   JOURNAL OF HEPATOLOGY

PI3K inhibition protects mice from NAFLD by down-regulating CMKLR1 and NLRP3 in Kupffer cells

(2017) Wenfeng Zhang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Puerarin inhibits expression of tissue factor induced by oxidative low-density lipoprotein through activating the PI3K/Akt/eNOS pathway and inhibiting activation of ERK1/2 and NF-κB

(2017) Hua-Fei Deng et al.   LIFE SCIENCES

Puerarin prevents tumor necrosis factor-α-induced apoptosis of PC12 cells via activation of the PI3K/Akt signaling pathway

(2017) Feng Liang et al.   Experimental and Therapeutic Medicine

Mitotherapy for Fatty Liver by Intravenous Administration of Exogenous Mitochondria in Male Mice

(2017) Ailing Fu et al.   Frontiers in Pharmacology

The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways

(2017) Xubo Chen et al.   Redox Biology

Differential Lipotoxic Effects of Palmitate and Oleate in Activated Human Hepatic Stellate Cells and Epithelial Hepatoma Cells

(2016) Alexandra M. Hetherington et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Puerarin protects against cadmium-induced proximal tubular cell apoptosis by restoring mitochondrial function

(2016) Xiang-Bin Song et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition

(2016) Shuai Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Protective effects of puerarin on acute lung and cerebrum injury induced by hypobaric hypoxia via the regulation of aquaporin (AQP) via NF-κB signaling pathway

(2016) Chi Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Metformin improves hepatic IRS2/PI3K/Akt signaling in insulin-resistant rats of NASH and cirrhosis

(2016) Hong Xu et al.   JOURNAL OF ENDOCRINOLOGY

Puerarin Protects Pancreatic β-Cells in Obese Diabetic Mice via Activation of GLP-1R Signaling

(2016) Lei Yang et al.   MOLECULAR ENDOCRINOLOGY

Shielding mitochondria from lipotoxicity prevents renal injury

(2016) Andrea Aguilar   Nature Reviews Nephrology

Effects of high fat diets on rodent liver bioenergetics and oxidative imbalance

(2016) Pâmela A. Kakimoto et al.   Redox Biology

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes

(2015) Samar H. Ibrahim et al.   HEPATOLOGY

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

(2015) Karim Gariani et al.   HEPATOLOGY

Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice

(2015) Zhi-Chun Zhang et al.   JOURNAL OF HEPATOLOGY

Botanical Drug Puerarin Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Neurotoxicity via Upregulating Mitochondrial Enzyme Arginase-2

(2015) Jia Zhao et al.   MOLECULAR NEUROBIOLOGY

CO2Pneumoperitoneum Preservesβ-Arrestin 2 Content and Reduces High Mobility Group Box-1 (HMGB-1) Expression in an Animal Model of Peritonitis

(2015) Angela Simona Montalto et al.   Oxidative Medicine and Cellular Longevity

Transcription of the Human Microsomal Epoxide Hydrolase Gene (EPHX1) Is Regulated by PARP-1 and Histone H1.2. Association with Sodium-Dependent Bile Acid Transport

(2015) Hui Peng et al.   PLoS One

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

(2014) Eija Pirinen et al.   Cell Metabolism

NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

(2014) Raffaele Cerutti et al.   Cell Metabolism

Botanical Drug Puerarin Coordinates with Nerve Growth Factor in the Regulation of Neuronal Survival and Neuritogenesis via Activating ERK1/2 and PI3K/Akt Signaling Pathways in the Neurite Extension Process

(2014) Jia Zhao et al.   CNS Neuroscience & Therapeutics

Oxysterols induce mitochondrial impairment and hepatocellular toxicity in non-alcoholic fatty liver disease

(2014) Francesco Bellanti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nonalcoholic Fatty Liver Disease: Pathogenesis and Therapeutics from a Mitochondria-Centric Perspective

(2014) Aaron M. Gusdon et al.   Oxidative Medicine and Cellular Longevity

PARP-Inhibitor Treatment Prevents Hypertension Induced Cardiac Remodeling by Favorable Modulation of Heat Shock Proteins, Akt-1/GSK-3β and Several PKC Isoforms

(2014) Laszlo Deres et al.   PLoS One

Non-alcoholic fatty liver disease

(2014) N. Sattar et al.   BMJ-British Medical Journal

HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression

(2014) De Huang et al.   Cell Reports

Maf1 Is a Novel Target of PTEN and PI3K Signaling That Negatively Regulates Oncogenesis and Lipid Metabolism

(2014) Beth M. Palian et al.   PLoS Genetics

Computational Peptidology: A New and Promising Approach to Therapeutic Peptide Design

(2013) P. Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Garlic-Derived S-Allylmercaptocysteine Ameliorates Nonalcoholic Fatty Liver Disease in a Rat Model through Inhibition of Apoptosis and Enhancing Autophagy

(2013) Jia Xiao et al.   Evidence-based Complementary and Alternative Medicine

Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway

(2013) Chao Guo et al.   FOOD AND CHEMICAL TOXICOLOGY

Natural and glucosyl flavonoids inhibit poly(ADP-ribose) polymerase activity and induce synthetic lethality in BRCA mutant cells

(2013) JUNKO MAEDA et al.   ONCOLOGY REPORTS

The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease

(2012) Péter Bai et al.   Cell Metabolism

ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation

(2012) Süheda Erener et al.   FASEB JOURNAL

Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants

(2012) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Exercise and non-alcoholic fatty liver disease: A systematic review and meta-analysis

(2012) Shelley E. Keating et al.   JOURNAL OF HEPATOLOGY

The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice

(2012) Jeevan K. Prasain et al.   PHYTOMEDICINE

Pancreatic-derived factor promotes lipogenesis in the mouse liver: Role of the Forkhead box 1 signaling pathway

(2011) Jing Li et al.   HEPATOLOGY

Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway

(2011) Chan-Min Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

PARP-1 inhibition-induced activation of PI-3-kinase-Akt pathway promotes resistance to taxol

(2009) Arpad Szanto et al.   BIOCHEMICAL PHARMACOLOGY