An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters

A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery

(2021) Hubert J. Sijben et al.   Scientific Reports

CRISPR screens in physiologic medium reveal conditionally essential genes in human cells

(2021) Nicholas J. Rossiter et al.   Cell Metabolism

Novel drug targets in 2020

(2021) Sorin Avram et al.   NATURE REVIEWS DRUG DISCOVERY

A Solid Supported Membrane-Based Technology for Electrophysical Screening of B0AT1-Modulating Compounds

(2021) Carolin Gerbeth-Kreul et al.   SLAS Discovery

Click Chemistry in Proteomic Investigations

(2020) Christopher G. Parker et al.   CELL

Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease

(2020) Melanie A. Felmlee et al.   PHARMACOLOGICAL REVIEWS

A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC

(2020) Robinson Arce-Molina et al.   eLife

CFTR Modulators: The Changing Face of Cystic Fibrosis in the Era of Precision Medicine

(2020) Miquéias Lopes-Pacheco   Frontiers in Pharmacology

Quantifying Target Occupancy of Small Molecules Within Living Cells

(2020) M.B. Robers et al.   Annual Review of Biochemistry

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs

(2020) Enrico Girardi et al.   Nature Chemical Biology

Unifying principles of bifunctional, proximity-inducing small molecules

(2020) Christopher J. Gerry et al.   Nature Chemical Biology

Novel drug targets in 2019

(2020) Sorin Avram et al.   NATURE REVIEWS DRUG DISCOVERY

The RESOLUTE consortium: unlocking SLC transporters for drug discovery

(2020) Giulio Superti-Furga et al.   NATURE REVIEWS DRUG DISCOVERY

L-Type amino acid transporter 1 as a target for drug delivery

(2020) Elena Puris et al.   PHARMACEUTICAL RESEARCH

Cooperative transport mechanism of human monocarboxylate transporter 2

(2020) Bo Zhang et al.   Nature Communications

Molecular Basis of Zinc-Dependent Endocytosis of Human ZIP4 Transceptor

(2020) Chi Zhang et al.   Cell Reports

A substrate‐based ontology for human solute carriers

(2020) Eva Meixner et al.   Molecular Systems Biology

Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

(2020) Tao Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A guide to plasma membrane solute carrier proteins

(2020) Mattia D. Pizzagalli et al.   FEBS Journal

An untargeted metabolomics strategy to measure differences in metabolite uptake and excretion by mammalian cell lines

(2020) Marina Wright Muelas et al.   Metabolomics

Structural Similarities between Some Common Fluorophores Used in Biology, Marketed Drugs, Endogenous Metabolites, and Natural Products

(2020) Steve O’Hagan et al.   Marine Drugs

MFSD12 mediates the import of cysteine into melanosomes and lysosomes

(2020) Charles H. Adelmann et al.   NATURE

The Gene Ontology resource: enriching a GOld mine

(2020) et al.   NUCLEIC ACIDS RESEARCH

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target

(2019) Sung-Jin Park et al.   Nature Communications

A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine

(2019) Jiesi Feng et al.   NEURON

Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex

(2019) Renhong Yan et al.   NATURE

The yeast mitochondrial pyruvate carrier is a hetero‐dimer in its functional state

(2019) Sotiria Tavoulari et al.   EMBO JOURNAL

Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport

(2019) Jonathan A. Coleman et al.   NATURE

Metabolic regulation of cell growth and proliferation

(2019) Jiajun Zhu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1

(2019) Wael L. Demian et al.   Cell Reports

CETSA® beyond soluble targets: a broad application to multi-pass transmembrane proteins

(2019) Aarti Kawatkar et al.   ACS Chemical Biology

Substrate Transport Properties of the Human Peptide/Histidine Transporter PHT2 in Transfected MDCK Cells

(2019) Yuqing Wang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

High-performance calcium sensors for imaging activity in neuronal populations and microcompartments

(2019) Hod Dana et al.   NATURE METHODS

A genetically encoded fluorescent sensor for in vivo imaging of GABA

(2019) Jonathan S. Marvin et al.   NATURE METHODS

Illustrate: Software for Biomolecular Illustration

(2019) David S. Goodsell et al.   STRUCTURE

Advances and Challenges in Rational Drug Design for SLCs

(2019) Rachel-Ann A. Garibsingh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies

(2019) Sook Wah Yee et al.   PLoS Genetics

High-Throughput Cellular Thermal Shift Assays in Research and Drug Discovery

(2019) Mark J. Henderson et al.   SLAS Discovery

Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments

(2019) Yasna Contreras-Baeza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic lethality as an engine for cancer drug target discovery

(2019) Alan Huang et al.   NATURE REVIEWS DRUG DISCOVERY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

(2019) Jane F Armstrong et al.   NUCLEIC ACIDS RESEARCH

The Rise of Physiologic Media

(2019) Jason R. Cantor   TRENDS IN CELL BIOLOGY

Label-free detection of transporter activity via GPCR signalling in living cells: A case for SLC29A1, the equilibrative nucleoside transporter 1

(2019) Anna Vlachodimou et al.   Scientific Reports

Affinity, binding kinetics and functional characterization of draflazine analogues for human equilibrative nucleoside transporter 1 (SLC29A1)

(2019) Anna Vlachodimou et al.   BIOCHEMICAL PHARMACOLOGY

Ultrafast Two-Photon Imaging of a High-Gain Voltage Indicator in Awake Behaving Mice

(2019) Vincent Villette et al.   CELL

A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells

(2019) Hee Chan Yoo et al.   Cell Metabolism

The Druggability of Solute Carriers

(2019) Wesley Wei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay

(2018) Mari Hashimoto et al.   ACS Chemical Biology

Constitutive activity of the metabotropic glutamate receptor 2 explored with a whole-cell label-free biosensor

(2018) Maarten L.J. Doornbos et al.   BIOCHEMICAL PHARMACOLOGY

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer

(2018) Elizabeth A. McMillan et al.   CELL

A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice

(2018) Fangmiao Sun et al.   CELL

The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification

(2018) Vitaly Sedlyarov et al.   Cell Host & Microbe

GPCR desensitization: Acute and prolonged phases

(2018) Sudarshan Rajagopal et al.   CELLULAR SIGNALLING

Molecular Modeling of Drug-Transporter Interactions-an International Transporter Consortium Perspective

(2018) Avner Schlessinger et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Region- and activity-dependent regulation of extracellular glutamate

(2018) Nawrin F. Pinky et al.   JOURNAL OF NEUROSCIENCE

Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies

(2018) David Broadhurst et al.   Metabolomics

Structural biology of solute carrier (SLC) membrane transport proteins

(2018) Xiaoyun Bai et al.   MOLECULAR MEMBRANE BIOLOGY

Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process

(2018) David Dickens et al.   MOLECULAR PHARMACEUTICS

A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies

(2018) Miao Jing et al.   NATURE BIOTECHNOLOGY

Designing cell function: assembly of synthetic gene circuits for cell biology applications

(2018) Mingqi Xie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Post-translational modifications of transporters

(2018) Lindsay C. Czuba et al.   PHARMACOLOGY & THERAPEUTICS

Mechanistic insights into GLUT1 activation and clustering revealed by super-resolution imaging

(2018) Qiuyan Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

(2018) Tommaso Patriarchi et al.   SCIENCE

The solute carrier SLC9C1 is a Na+/H+-exchanger gated by an S4-type voltage-sensor and cyclic-nucleotide binding

(2018) F. Windler et al.   Nature Communications

CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1

(2018) Kevin W. Huynh et al.   Nature Communications

A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase

(2018) Natalia J. Martinez et al.   Scientific Reports

MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells

(2018) Naoki Kobayashi et al.   Scientific Reports

GeneGini: Assessment via the Gini Coefficient of Reference “Housekeeping” Genes and Diverse Human Transporter Expression Profiles

(2018) Steve O'Hagan et al.   Cell Systems

Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking

(2018) Astrid Fauster et al.   CELL DEATH AND DIFFERENTIATION

Cytosolic sodium regulation in mouse cortical astrocytes and its dependence on potassium and bicarbonate

(2018) Zinnia N. Noor et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1)

(2018) Huan-Chieh Chien et al.   JOURNAL OF MEDICINAL CHEMISTRY

Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS

(2018) William H. Zhang et al.   Nature Chemical Biology

Amino acid transporters revisited: New views in health and disease

(2018) Palanivel Kandasamy et al.   TRENDS IN BIOCHEMICAL SCIENCES

In silico Prioritization of Transporter–Drug Relationships From Drug Sensitivity Screens

(2018) Adrián César-Razquin et al.   Frontiers in Pharmacology

Homology Modeling Informs Ligand Discovery for the Glutamine Transporter ASCT2

(2018) Rachel-Ann A. Garibsingh et al.   Frontiers in Chemistry

Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks

(2018) Eric C. Greenwald et al.   CHEMICAL REVIEWS

A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila

(2018) Naoki Okamoto et al.   DEVELOPMENTAL CELL

A Chemical Biology View of Bioactive Small Molecules and a Binder-Based Approach to Connect Biology to Precision Medicines

(2018) Stuart L. Schreiber   ISRAEL JOURNAL OF CHEMISTRY

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

(2018) Sho Morioka et al.   NATURE

Discovery of a ZIP7 inhibitor from a Notch pathway screen

(2018) Erin Nolin et al.   Nature Chemical Biology

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

(2018) Nora Kory et al.   SCIENCE

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

(2018) Don Benjamin et al.   Cell Reports

Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1

(2018) Joseph Shaw et al.   SLAS Discovery

Identification and Characterization of Inhibitors of a Neutral Amino Acid Transporter, SLC6A19, Using Two Functional Cell-Based Assays

(2018) Sanjay J. Danthi et al.   SLAS Discovery

Identification of competitive inhibitors of the human taurine transporter TauT in a human kidney cell line

(2018) Michelle Richter et al.   Pharmacological Reports

An overview of Ca2+mobilization assays in GPCR drug discovery

(2017) Qiang Ma et al.   Expert Opinion on Drug Discovery

A Short Guide to Electrophysiology and Ion Channels

(2017) Hussein Nori Rubaiy   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

ICP-MS/MS-Based Ionomics: A Validated Methodology to Investigate the Biological Variability of the Human Ionome

(2017) Tobias Konz et al.   JOURNAL OF PROTEOME RESEARCH

Structure and allosteric inhibition of excitatory amino acid transporter 1

(2017) Juan C. Canul-Tec et al.   NATURE

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

(2017) Thiet M. Vu et al.   NATURE

Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites

(2017) Walter W Chen et al.   Nature Protocols

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Measuring inhibition of monoamine reuptake transporters by new psychoactive substances (NPS) in real-time using a high-throughput, fluorescence-based assay

(2017) Anne Zwartsen et al.   TOXICOLOGY IN VITRO

Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action

(2017) Javier R. Jaldin-Fincati et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Classification Systems of Secondary Active Transporters

(2017) Emelie Perland et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Ratiometric Matryoshka biosensors from a nested cassette of green- and orange-emitting fluorescent proteins

(2017) Cindy Ast et al.   Nature Communications

Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs

(2017) Christopher G. Parker et al.   ACS Central Science

Establishing a yeast-based screening system for discovery of human GLUT5 inhibitors and activators

(2017) Joanna Tripp et al.   Scientific Reports

Formation of a cytoplasmic salt bridge network in the matrix state is a fundamental step in the transport mechanism of the mitochondrial ADP/ATP carrier

(2016) Martin S. King et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reuse of E-plate cell sensor arrays in the xCELLigence Real-Time Cell Analyzer

(2016) Justyna Stefanowicz-Hajduk et al.   BIOTECHNIQUES

Patch clamp

(2016) Alexander PY Brown et al.   BRITISH JOURNAL OF HOSPITAL MEDICINE

Comparison of fluorescence probes for intracellular sodium imaging in prostate cancer cell lines

(2016) Oksana Iamshanova et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity

(2016) Bradley A. Webb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology

(2016) Maria Barthmes et al.   JOURNAL OF GENERAL PHYSIOLOGY

Docking Screens for Novel Ligands Conferring New Biology

(2016) John J. Irwin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family

(2016) Kim Huard et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glutamate Clearance Is Locally Modulated by Presynaptic Neuronal Activity in the Cerebral Cortex

(2016) Moritz Armbruster et al.   JOURNAL OF NEUROSCIENCE

MAP17 Is a Necessary Activator of Renal Na+/Glucose Cotransporter SGLT2

(2016) Michael J. Coady et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The ChEMBL database in 2017

(2016) Anna Gaulton et al.   NUCLEIC ACIDS RESEARCH

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

(2016) Helena Almqvist et al.   Nature Communications

Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients

(2016) Gabriela Jiménez-Valerio et al.   Cell Reports

Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy

(2016) Laura Pisarsky et al.   Cell Reports

Fluorescence polarization assays in high-throughput screening and drug discovery: a review

(2016) Matthew D Hall et al.   Methods and Applications in Fluorescence

High throughput screening technologies for ion channels

(2015) Hai-bo Yu et al.   ACTA PHARMACOLOGICA SINICA

Toward Merging Untargeted and Targeted Methods in Mass Spectrometry-Based Metabolomics and Lipidomics

(2015) Tomas Cajka et al.   ANALYTICAL CHEMISTRY

Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies

(2015) Young Joo Jeon et al.   CANCER CELL

A Call for Systematic Research on Solute Carriers

(2015) Adrián César-Razquin et al.   CELL

Nature and uses of fluorescent dyes for drug transporter studies

(2015) Olivier Fardel et al.   Expert Opinion on Drug Metabolism & Toxicology

Cysteine is not a substrate but a specific modulator of human ASCT2 (SLC1A5) transporter

(2015) Mariafrancesca Scalise et al.   FEBS LETTERS

OS9 Protein Interacts with Na-K-2Cl Co-transporter (NKCC2) and Targets Its Immature Form for the Endoplasmic Reticulum-associated Degradation Pathway

(2015) Elie Seaayfan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling

(2015) Kilian V M Huber et al.   NATURE METHODS

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins

(2015) Friedrich B M Reinhard et al.   NATURE METHODS

ChEMBL web services: streamlining access to drug discovery data and utilities

(2015) Mark Davies et al.   NUCLEIC ACIDS RESEARCH

Glycosylation of solute carriers: mechanisms and functional consequences

(2015) Nis Borbye Pedersen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)

(2015) Kim Huard et al.   Scientific Reports

Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4

(2014) Cheng-Yu Tsai et al.   BIOCHEMICAL PHARMACOLOGY

IRBIT: A regulator of ion channels and ion transporters

(2014) Hideaki Ando et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Advantages of cell-based high-volume screening assays to assess nuclear receptor activation during drug discovery

(2014) Marija Pinne et al.   Expert Opinion on Drug Discovery

A new strategy for MS/MS data acquisition applying multiple data dependent experiments on Orbitrap mass spectrometers in non-targeted metabolomic applications

(2014) Graham Mullard et al.   Metabolomics

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

Copper is required for oncogenic BRAF signalling and tumorigenesis

(2014) Donita C. Brady et al.   NATURE

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

(2014) Georg E Winter et al.   Nature Chemical Biology

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

Pharmacological Identification of a Guanidine-Containing β-Alanine Analogue with Low Micromolar Potency and Selectivity for the Betaine/GABA Transporter 1 (BGT1)

(2014) Anas Al-Khawaja et al.   NEUROCHEMICAL RESEARCH

A Genetically-Encoded YFP Sensor with Enhanced Chloride Sensitivity, Photostability and Reduced pH Interference Demonstrates Augmented Transmembrane Chloride Movement by Gerbil Prestin (SLC26a5)

(2014) Sheng Zhong et al.   PLoS One

Genome-wide RNAi ionomics screen reveals new genes and regulation of human trace element metabolism

(2014) Mikalai Malinouski et al.   Nature Communications

New Fluorescent Substrate Enables Quantitative and High-Throughput Examination of Vesicular Monoamine Transporter 2 (VMAT2)

(2013) Gang Hu et al.   ACS Chemical Biology

Method for Accurate Determination of Dissociation Constants of Optical Ratiometric Systems: Chemical Probes, Genetically Encoded Sensors, and Interacting Molecules

(2013) Adam Pomorski et al.   ANALYTICAL CHEMISTRY

Isothermal titration calorimetry of membrane proteins — Progress and challenges

(2013) Krishna Rajarathnam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

High-throughput fluorescent-based NKCC functional assay in adherent epithelial cells

(2013) Monica Carmosino et al.   BMC CELL BIOLOGY

The heteromeric organic solute transporter, OSTα–OSTβ/SLC51: A transporter for steroid-derived molecules

(2013) Nazzareno Ballatori et al.   MOLECULAR ASPECTS OF MEDICINE

The ABCs of membrane transporters in health and disease (SLC series): Introduction

(2013) Matthias A. Hediger et al.   MOLECULAR ASPECTS OF MEDICINE

The SLC3 and SLC7 families of amino acid transporters

(2013) Dimitrios Fotiadis et al.   MOLECULAR ASPECTS OF MEDICINE

An optimized fluorescent probe for visualizing glutamate neurotransmission

(2013) Jonathan S Marvin et al.   NATURE METHODS

Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters

(2013) Tina Hofmaier et al.   NEUROCHEMISTRY INTERNATIONAL

Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1

(2013) E. G. Geier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Introduction to Solid Supported Membrane Based Electrophysiology

(2013) Andre Bazzone et al.   Jove-Journal of Visualized Experiments

Tools for GPCR drug discovery

(2012) Ru Zhang et al.   ACTA PHARMACOLOGICA SINICA

Current trends and challenges in sample preparation for global metabolomics using liquid chromatography–mass spectrometry

(2012) Dajana Vuckovic   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Using label-free screening technology to improve efficiency in drug discovery

(2012) Reena Halai et al.   Expert Opinion on Drug Discovery

Discovery of Potent, Selective Multidrug and Toxin Extrusion Transporter 1 (MATE1, SLC47A1) Inhibitors Through Prescription Drug Profiling and Computational Modeling

(2012) Matthias B. Wittwer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of the Niemann-Pick C1–like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor

(2012) Bruno Sainz et al.   NATURE MEDICINE

Visualization of Glutamine Transporter Activities in Living Cells Using Genetically Encoded Glutamine Sensors

(2012) Katrin Gruenwald et al.   PLoS One

Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells

(2012) Yu Hisano et al.   PLoS One

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes

(2011) Tom De Bruyn et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Optical sensors for monitoring dynamic changes of intracellular metabolite levels in mammalian cells

(2011) Bi-Huei Hou et al.   Nature Protocols

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

(2011) Warwick B Dunn et al.   Nature Protocols

Electrophysiology of Respiratory Chain Complexes and the ADP−ATP Exchanger in Native Mitochondrial Membranes

(2010) Natalie Watzke et al.   BIOCHEMISTRY

Label-free whole-cell assays: expanding the scope of GPCR screening

(2010) Clay W Scott et al.   DRUG DISCOVERY TODAY

Evaluation of 4',6-Diamidino-2-phenylindole as a Fluorescent Probe Substrate for Rapid Assays of the Functionality of Human Multidrug and Toxin Extrusion Proteins

(2010) T. Yasujima et al.   DRUG METABOLISM AND DISPOSITION

Molecular origin of plasma membrane citrate transporter in human prostate epithelial cells

(2010) Maciej P Mazurek et al.   EMBO REPORTS

Facilitative plasma membrane transporters function during ER transit

(2010) Hitomi Takanaga et al.   FASEB JOURNAL

The Solute Carrier Families Have a Remarkably Long Evolutionary History with the Majority of the Human Families Present before Divergence of Bilaterian Species

(2010) P. J. Hoglund et al.   MOLECULAR BIOLOGY AND EVOLUTION

Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns

(2010) W. Edward Visser et al.   MOLECULAR ENDOCRINOLOGY

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Comparison of human solute carriers

(2010) Avner Schlessinger et al.   PROTEIN SCIENCE

Structural perspectives on secondary active transporters

(2010) Olga Boudker et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification and characterization of small compound inhibitors of human FATP2

(2009) Angel Sandoval et al.   BIOCHEMICAL PHARMACOLOGY

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Genetically Encoded Biosensors Using Firefly Luciferase

(2008) Frank Fan et al.   ACS Chemical Biology

The application of cell-based label-free technology in drug discovery

(2008) Biao Xi et al.   Biotechnology Journal

SSM-based electrophysiology

(2008) Patrick Schulz et al.   METHODS

Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells

(2008) Andrey V Kuznetsov et al.   Nature Protocols

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

(2008) Paul D. Dobson et al.   NATURE REVIEWS DRUG DISCOVERY

The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

(2008) A. Kawahara et al.   SCIENCE

Microscale Fluorescent Thermal Stability Assay for Membrane Proteins

(2008) Alexander I. Alexandrov et al.   STRUCTURE