Discovery of a ZIP7 inhibitor from a Notch pathway screen

The zinc transporter SLC39A7 (ZIP7) is essential for regulation of cytosolic zinc levels

(2018) Grace Woodruff et al.   MOLECULAR PHARMACOLOGY

Requirement of Zinc Transporter SLC39A7/ZIP7 for Dermal Development to Fine-Tune Endoplasmic Reticulum Function by Regulating Protein Disulfide Isomerase

(2017) Bum-Ho Bin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis

(2017) Takafumi Hara et al.   Journal of Physiological Sciences

Opportunities and challenges in phenotypic drug discovery: an industry perspective

(2017) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

Leveraging Chemotype-Specific Resistance for Drug Target Identification and Chemical Biology

(2017) Tarun M. Kapoor et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway

(2017) Tuo Zhang et al.   Science Advances

Droplet Microfluidic Flow Cytometer For Sorting On Transient Cellular Responses Of Genetically-Encoded Sensors

(2016) Brett L. Fiedler et al.   ANALYTICAL CHEMISTRY

Zinc transporters and signaling in physiology and pathogenesis

(2016) Shintaro Hojyo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Identifying compound efficacy targets in phenotypic drug discovery

(2016) Markus Schirle et al.   DRUG DISCOVERY TODAY

Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies

(2016) P Bernasconi-Elias et al.   ONCOGENE

Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress

(2016) Wakana Ohashi et al.   PLoS Genetics

Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

(2015) Shashank Tripathi et al.   Cell Host & Microbe

SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

(2015) James Palacino et al.   Nature Chemical Biology

Significance of glycosylation in Notch signaling

(2014) Hideyuki Takeuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis

(2014) Bahar Yilmazel et al.   BMC BIOINFORMATICS

Variomics Screen Identifies the Re-entrant Loop of the Calcium-activated Chloride Channel ANO1 That Facilitates Channel Activation

(2014) Anke Bill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer

(2013) Giovanni Roti et al.   CANCER CELL

Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup

(2013) C. Groth et al.   DEVELOPMENT

Notch signaling at a glance

(2013) K. Hori et al.   JOURNAL OF CELL SCIENCE

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

(2013) Dominic Hoepfner et al.   MICROBIOLOGICAL RESEARCH

The SLC39 family of zinc transporters

(2013) Jeeyon Jeong et al.   MOLECULAR ASPECTS OF MEDICINE

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

A Functional Variomics Tool for Discovering Drug-Resistance Genes and Drug Targets

(2013) Zhiwei Huang et al.   Cell Reports

Targeting the Notch Pathway: Twists and Turns on the Road to Rational Therapeutics

(2012) Jon C. Aster et al.   JOURNAL OF CLINICAL ONCOLOGY

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Using transcriptome sequencing to identify mechanisms of drug action and resistance

(2012) Sarah A Wacker et al.   Nature Chemical Biology

A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens

(2012) Frederic D Sigoillot et al.   NATURE METHODS

The Notch signalling system: recent insights into the complexity of a conserved pathway

(2012) K. G. Guruharsha et al.   NATURE REVIEWS GENETICS

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Measuring steady-state and dynamic endoplasmic reticulum and Golgi Zn2+ with genetically encoded sensors

(2011) Y. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor

(2010) William McLaren et al.   BIOINFORMATICS

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

(2009) Mark E. Fortini   DEVELOPMENTAL CELL

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

arrayQualityMetrics—a bioconductor package for quality assessment of microarray data

(2008) Audrey Kauffmann et al.   BIOINFORMATICS

Therapeutic Potential of γ -Secretase Inhibitors and Modulators

(2008) Bruno Imbimbo   CURRENT TOPICS IN MEDICINAL CHEMISTRY