LPC-DHA/EPA-Enriched Diets Increase Brain DHA and Modulate Behavior in Mice That Express Human APOE4

Effect of APOE Genotype on Plasma Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid, Arachidonic Acid, and Hippocampal Volume in the Alzheimer’s Disease Cooperative Study-Sponsored DHA Clinical Trial

(2020) Natalie Tomaszewski et al.   JOURNAL OF ALZHEIMERS DISEASE

APOE in the normal brain

(2020) Sarah A. Flowers et al.   NEUROBIOLOGY OF DISEASE

In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET

(2020) Adam P. Mecca et al.   Alzheimers & Dementia

Lipase Treatment of Dietary Krill Oil, but Not Fish Oil, Enables Enrichment of Brain Eicosapentaenoic Acid and Docosahexaenoic Acid

(2020) Poorna C. R. Yalagala et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial

(2020) Isabella C. Arellanes et al.   EBioMedicine

Antarctic Krill (Euphausia superba ) Oil: A Comprehensive Review of Chemical Composition, Extraction Technologies, Health Benefits, and Current Applications

(2019) Dan Xie et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

EGF Treatment Improves Motor Behavior and Cortical GABAergic Function in the R6/2 Mouse Model of Huntington’s Disease

(2019) Felecia M. Marottoli et al.   MOLECULAR NEUROBIOLOGY

Omega-3 PUFA metabolism and brain modifications during aging

(2019) Laurie Chevalier et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Enrichment of brain docosahexaenoic acid (DHA) is highly dependent upon the molecular carrier of dietary DHA: Lysophosphatidylcholine is more efficient than either phosphatidylcholine or triacylglycerol

(2019) Dhavamani Sugasini et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging

(2018) Ming-Kai Chen et al.   JAMA Neurology

The Isoform-Specific Pathological Effects of ApoE4 in vivo are Prevented by a Fish Oil (DHA) Diet and are Modified by Cholesterol

(2018) Zehavit Kariv-Inbal et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer’s disease

(2018) Rhonda P. Patrick   FASEB JOURNAL

DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA

(2017) Hussein N. Yassine et al.   Alzheimers Research & Therapy

Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E ε4 Carriers

(2017) Hussein N. Yassine et al.   JAMA Neurology

Dietary docosahexaenoic acid (DHA) as lysophosphatidylcholine, but not as free acid, enriches brain DHA and improves memory in adult mice

(2017) Dhavamani Sugasini et al.   Scientific Reports

Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases

(2016) Amanda Lo Van et al.   BIOCHIMIE

Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders

(2016) Robert W. Mahley   JOURNAL OF MOLECULAR MEDICINE-JMM

The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer's disease

(2016) Mounir Belkouch et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Docosahexaenoic Acid and Cognition throughout the Lifespan

(2016) Michael Weiser et al.   Nutrients

Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and cerebrovascular deficits in female mice

(2016) Riya Thomas et al.   Acta Neuropathologica Communications

β-oxidation and rapid metabolism, but not uptake regulate brain eicosapentaenoic acid levels

(2015) Chuck T. Chen et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Amyloid-β Pathology andAPOEGenotype Modulate Retinoid X Receptor Agonist Activityin Vivo

(2014) Leon M. Tai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Apolipoprotein E isoforms disrupt long-chain fatty acid distribution in the plasma, the liver and the adipose tissue of mice

(2014) Valérie Conway et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE ε4 allele

(2013) R. Chouinard-Watkins et al.   BRITISH JOURNAL OF NUTRITION

Levels of Soluble Apolipoprotein E/Amyloid-β (Aβ) Complex Are Reduced and Oligomeric Aβ Increased withAPOE4and Alzheimer Disease in a Transgenic Mouse Model and Human Samples

(2013) Leon M. Tai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction in DHA transport to the brain of mice expressing humanAPOE4compared toAPOE2

(2013) Milène Vandal et al.   JOURNAL OF NEUROCHEMISTRY

Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex

(2013) G. A. Rodriguez et al.   LEARNING & MEMORY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline

(2013) Marie Hennebelle et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

(2012) Katherine L. Youmans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence?

(2012) Stephen C. Cunnane et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Docosahexaenoic Acid (DHA): An Ancient Nutrient for the Modern Human Brain

(2011) Joanne Bradbury   Nutrients

Dietary fatty acids and the aging brain

(2010) Greg M Cole et al.   NUTRITION REVIEWS

Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function

(2009) Dehua Cao et al.   JOURNAL OF NEUROCHEMISTRY

Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks

(2008) Alexandra Bour et al.   BEHAVIOURAL BRAIN RESEARCH