Article
Biochemistry & Molecular Biology
Dhavamani Sugasini, Peng Yang, Dominic Ng, Sumeet A. Khetarpal, Cecilia Vitali, J. Rader Daniel, Papasani Subbaiah
Summary: DHA is essential for brain development and function, with the brain acquiring it from the plasma. Research suggests that HL may be the major source for generating LPC-DHA in the plasma, necessary for transport into the brain.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Geriatrics & Gerontology
Julien Schmitt, Anne-Lise Paradis, Mathieu Boucher, Laurent Andrieu, Pascal Barneoud, Laure Rondi-Reig
Summary: The study suggests that ApoE4 may lead to flexibility deficits in mice at a younger age, but not memory deficits. The flexibility deficit associated with ApoE4 does not worsen with age or predict memory performance.
NEUROBIOLOGY OF AGING
(2021)
Article
Biochemistry & Molecular Biology
Theresa L. Powell, Kelsey Barner, Lana Madi, Michael Armstrong, Jonathan Manke, Charis Uhlson, Thomas Jansson, Veronique Ferchaud-Roucher
Summary: Maternal obesity affects placental metabolism and transport of fatty acids, leading to reduced DHA in male fetuses and altered esterification enzymes in female placentas. These differences may contribute to neurological consequences in male children and impaired lipid transfer in female placentas of obese mothers.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Review
Biochemistry & Molecular Biology
Mariana Pires, Ana Cristina Rego
Summary: APOE epsilon 4 allele (ApoE4) is the primary genetic risk factor for sporadic Alzheimer's disease (AD), associated with cognitive impairment and neurodegeneration. ApoE4 impacts mitochondrial function, increases reactive oxygen species (ROS) and calcium levels, affects mitochondrial dynamics and translocates to the nucleus to regulate gene expression related to aging, amyloid-beta production, inflammation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Laura Martinez Gonzalez, Adam Bourissai, Melissa Lessard-Beaudoin, Rejean Lebel, Luc Tremblay, Martin Lepage, Rona K. Graham
Summary: Olfactory dysfunction and atrophy of olfactory brain regions are early indicators of cognitive impairment and Alzheimer's disease. This study investigated the effects of docosahexaenoic acid (DHA) on olfactory deficits in APOE4 mice. The results showed that APOE4 mice on a control diet exhibited memory deficits and abnormal olfactory behavior, while those on a DHA diet did not. These findings suggest that a diet rich in DHA may have some benefits for individuals with the APOE4 gene, but may not alleviate all symptoms.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Alejandro Martinez-Gayo, Elisa Felix-Soriano, Neira Sainz, Pedro Gonzalez-Muniesa, Maria J. Moreno-Aliaga
Summary: Obesity and aging promote chronic low-grade systemic inflammation. This study aimed to analyze the effects of long-term physical exercise and/or omega-3 fatty acid DHA supplementation on muscle metabolism, inflammation, muscle damage/regeneration, and myokine expression in aged and obese mice. The results showed that long-term exercise can prevent the deleterious effects of aging and obesity on muscle function.
Article
Clinical Neurology
Hussein Yassine, I. C. Arellanes, A. Mazmanian, L. de la Cruz, J. Martinez, L. Contreras, N. Kono, B. S. Liu, D. Badie, M. A. Bantugan, A. Grindon, T. Urich, L. D'Orazio, B. A. Emmanuel, H. C. Chui, W. J. Mack, M. G. Harrington, M. N. Braskie, L. S. Schneider
Summary: This study aims to investigate whether DHA supplementation can delay or slow down the progression of clinical dementia in APOE ε4 carriers. The double-blind, randomized, placebo-controlled trial involves 368 cognitively unimpaired individuals with limited DHA consumption and dementia risk factors for a period of 2 years. The results will provide new insights into the brain delivery of DHA in APOE ε4 carriers for dementia prevention strategies.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Elisa Felix-Soriano, Neira Sainz, Marta Fernandez-Galilea, Eva Gil-Iturbe, Jon Celay, Jose A. Martinez-Climent, Maria J. Moreno-Aliaga
Summary: This study aimed to investigate the potential beneficial effects of chronic docosahexaenoic acid (DHA) supplementation on restoring subcutaneous white adipose tissue (scWAT) plasticity in obese aged female mice. The results showed that the DHA-enriched diet reduced adipocyte size and reversed the upregulation of lipogenic genes induced by the high fat diet (HFD). DHA supplementation restored the increase of proinflammatory genes, switched scWAT macrophages profile to a healthier phenotype, and induced beige adipocyte markers in obese aged mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Neurosciences
Ilona Har-Paz, Elor Arieli, Anan Moran
Summary: The E4 allele of apolipoprotein E is the strongest genetic risk factor for late-onset Alzheimer's disease, potentially causing innate brain abnormalities before the onset of AD. Studies suggest that apoE4 may affect memory and learning abilities in young rats, leading to changes in neuronal activity.
NEUROBIOLOGY OF DISEASE
(2021)
Editorial Material
Neurosciences
Michael T. Heneka
Summary: In this article, the ApoE-Trem2 pathway is found to connect two of the most important genetic risk variants for sporadic Alzheimer's disease. The deficiency of Trem2 is shown to further aggravate neurodegeneration in tau mutant mice expressing human ApoE4, indicating a complex interaction among different variants of human ApoE. These findings emphasize the importance of studying molecular interactions on all human ApoE variants.
Article
Cell Biology
Qiujian Yu, Xiaoqin Cheng
Summary: This study aimed to propose membrane aging as a critical pathogenesis of Alzheimer's disease (AD) and established a hydroxyurea-induced membrane aging model to further prove this hypothesis.
Article
Biochemistry & Molecular Biology
Matthew G. Pontifex, Anneloes Martinsen, Rasha Noureldin M. Saleh, Glenn Harden, Noemi Tejera, Michael Mueller, Chris Fox, David Vauzour, Anne-Marie Minihane
Summary: The impact of sex and menopausal status in Alzheimer's disease remains understudied, with increasing evidence of greater female risk, especially in APOE4 carriers. Experimental findings suggest that the combination of ovarian failure and APOE4 genotype exacerbates cognitive and neurological deficits in Alzheimer's disease.
Article
Neurosciences
Aiqing Nie, Yuanying Wu
Summary: Previous research has identified two different old/new effects in cognitive processes, FN400 and LPC. The role of familiarity and recollection in associative recognition has been explored, but it is still unclear if old/new effects are influenced by semantic relations. This study used ERP to investigate the impact of thematic, taxonomic, and unrelated relations on recognition.
Review
Neurosciences
Angeles C. Tecalco-Cruz, Jesus Zepeda-Cervantes, Lilia Lopez-Canovas, Josue Oriando Ramirez-Jarquin, Jose Pedraza-Chaverri, Alfredo Briones-Herrera
Summary: Alzheimer's Disease is characterized by progressive memory loss due to neurodegeneration that occurs mainly during aging. Accumulation of senescent cells and expression of the variant ApoE epsilon 4 have been identified as critical risk factors for AD. Events such as secretion of pro-inflammatory molecules, metabolic and epigenetic changes, along with the detection of ApoE4, may accelerate the progression of AD.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2021)
Article
Biochemistry & Molecular Biology
Elisa Felix-Soriano, Neira Sainz, Eva Gil-Iturbe, Maria Collantes, Marta Fernandez-Galilea, Rosa Castilla-Madrigal, Lucy Ly, Jesmond Dalli, Maria J. Moreno-Aliaga
Summary: The dysfunction of brown adipose tissue (BAT) in aging and obesity may be related to a decrease in production of specialized proresolving lipid mediators (SPMs), especially under chronic unresolved inflammation. While a diet rich in docosahexaenoic acid (DHA) can partially restore BAT dysfunction, it does not significantly alter the levels of specific SPMs. Despite increasing DHA-derived SPMs, it does not improve the response of BAT to cold exposure in obese-aged mice.
Article
Chemistry, Medicinal
Poorna C. R. Yalagala, Dhavamani Sugasini, Talahalli Ravichandra Ramaprasad, Belur Ramaswamy Lokesh
JOURNAL OF MEDICINAL FOOD
(2017)
Article
Chemistry, Applied
B. L. A. Prabhavathi Devi, K. N. Gangadhar, R. B. N. Prasad, D. Sugasini, Y. Poorna Chandra Rao, B. R. Lokesh
Article
Biochemistry & Molecular Biology
Poorna C. R. Yalagala, Dhavamani Sugasini, Sridevi Dasarathi, Kalipada Pahan, Papasani V. Subbaiah
JOURNAL OF LIPID RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Jose Cordoba-Chacon, Dhavamani Sugasini, Poorna C. R. Yalagala, Apoorva Tummala, Zachary C. White, Toshihiro Nagao, Rhonda D. Kineman, Papasani V. Subbaiah
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Dhavamani Sugasini, Poorna C. R. Yalagala, Alexis Goggin, Leon M. Tai, Papasani V. Subbaiah
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2019)
Article
Agriculture, Multidisciplinary
Jeyakumar Balakrishnan, Sugasini Dhavamani, Selvam Govindan Sadasivam, Muthu Arumugam, Sampathrajan Vellaikumar, Jagadeesan Ramalingam, Kathiresan Shanmugam
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2019)
Article
Food Science & Technology
Poorna C. R. Yalagala, Dhavamani Sugasini, Steve B. Zaldua, Leon M. Tai, Papasani V. Subbaiah
MOLECULAR NUTRITION & FOOD RESEARCH
(2020)
Article
Multidisciplinary Sciences
Dhavamani Sugasini, Poorna C. R. Yalagala, Papasani V. Subbaiah
SCIENTIFIC REPORTS
(2020)
Review
Developmental Biology
Sivasangari Balakrishnan, Sugasini Dhavamani, Chidambaram Prahalathan
MECHANISMS OF DEVELOPMENT
(2020)
Article
Nutrition & Dietetics
Dhavamani Sugasini, Poorna C. R. Yalagala, Papasani V. Subbaiah
Article
Genetics & Heredity
Sumeet A. Khetarpal, Cecilia Vitali, Michael G. Levin, Derek Klarin, Joseph Park, Akhil Pampana, John S. Millar, Takashi Kuwano, Dhavamani Sugasini, Papasani Subbaiah, Jeffrey T. Billheimer, Pradeep Natarajan, Daniel J. Rader
Summary: Research showed that endothelial lipase (EL) plays a key role in the metabolism of triglyceride-rich lipoproteins (TRLs) by collaborating with lipoprotein lipase (LPL) to mediate efficient lipolysis in humans and mice. By studying the impact of genetic EL loss-of-function on TRL metabolism in humans and mice, it was found that EL is important in providing fatty acids to tissues and contributing to lipolysis of TRLs.
Article
Biochemistry & Molecular Biology
Dhavamani Sugasini, Peng Yang, Dominic Ng, Sumeet A. Khetarpal, Cecilia Vitali, J. Rader Daniel, Papasani Subbaiah
Summary: DHA is essential for brain development and function, with the brain acquiring it from the plasma. Research suggests that HL may be the major source for generating LPC-DHA in the plasma, necessary for transport into the brain.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
Mounica Bandela, Vidyani Suryadevara, Panfeng Fu, Sekhar P. Reddy, Kamesh Bikkavilli, Long Shuang Huang, Sugasini Dhavamani, Papasani V. Subbaiah, Sunit Singla, Steven M. Dudek, Lorraine B. Ware, Ramaswamy Ramchandran, Viswanathan Natarajan
Summary: The study investigated the role of LYCAT in cigarette smoke-induced oxidative damage and apoptosis in the lungs. Increased LYCAT expression was found to promote mitochondrial oxidative stress, dynamics, and apoptosis of lung epithelial cells.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Jeyakumar Balakrishnan, Bhalram Krishnan, Thiyagarajan Sekar, Parthasarathy Ayothi, Ramkumar Muthu, Vellaikumar Sampathrajan, Arumugam Muthu, Sugasini Dhavamani, Kathiresan Shanmugam
Summary: This study investigated the neuroprotective role of microalgal derived omega-3 PUFAs in monosodium glutamate (MSG)-induced neurotoxicity in F-1 rats. The results showed that microalga-treated rats had higher levels of DHA and ARA in the brain tissues, significantly reduced MDA levels, and improved neurotoxicity through the activation of CREB and BDNF genes. In addition, the expressions of antioxidant genes and apoptotic genes were reduced in the microalga-treated rats, and histopathological results showed minimal tissue damage.
NEUROCHEMISTRY INTERNATIONAL
(2022)