Relationship between hemagglutinin stability and influenza virus persistence after exposure to low pH or supraphysiological heating

Interplay between H1N1 influenza a virus infection, extracellular and intracellular respiratory tract pH, and host responses in a mouse model

(2021) Faten A. Okda et al.   PLoS One

Cell-Culture Adaptation of H3N2 Influenza Virus Impacts Acid Stability and Reduces Airborne Transmission in Ferret Model

(2021) Valerie Le Sage et al.   Viruses-Basel

Characterising viable virus from air exhaled by H1N1 influenza-infected ferrets reveals the importance of haemagglutinin stability for airborne infectivity

(2020) Anika Singanayagam et al.   PLoS Pathogens

Characterizing Emerging Canine H3 Influenza Viruses

(2020) Luis Martinez-Sobrido et al.   PLoS Pathogens

Influenza virus with increased pH of HA activation has improved replication in cell culture but at the cost of infectivity in human airway epithelium

(2019) Anika Singanayagam et al.   JOURNAL OF VIROLOGY

HA stability regulates H1N1 influenza virus replication and pathogenicity in mice by modulating type I interferon responses in dendritic cells

(2019) Marion Russier et al.   JOURNAL OF VIROLOGY

Influenza Hemagglutinin Protein Stability, Activation, and Pandemic Risk

(2018) Charles J. Russell et al.   TRENDS IN MICROBIOLOGY

Influenza Virus Segment Composition Influences Viral Stability in the Environment

(2018) Thomas Labadie et al.   Frontiers in Microbiology

Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics

(2018) Eili Y. Klein et al.   mSphere

Human Clade 2.3.4.4 A/H5N6 Influenza Virus Lacks Mammalian Adaptation Markers and Does Not Transmit via the Airborne Route between Ferrets

(2018) Sander Herfst et al.   mSphere

Host and viral determinants of influenza A virus species specificity

(2018) Jason S. Long et al.   NATURE REVIEWS MICROBIOLOGY

pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs

(2017) Thomas Gerlach et al.   JOURNAL OF VIROLOGY

The microbiota of the respiratory tract: gatekeeper to respiratory health

(2017) Wing Ho Man et al.   NATURE REVIEWS MICROBIOLOGY

H1N1 influenza viruses varying widely in hemagglutinin stability transmit efficiently from swine to swine and to ferrets

(2017) Marion Russier et al.   PLoS Pathogens

Environmental Stability of Swine and Human Pandemic Influenza Viruses in Water under Variable Conditions of Temperature, Salinity, and pH

(2016) R. L. Poulson et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Amino Acid Substitutions That Affect Receptor Binding and Stability of the Hemagglutinin of Influenza A/H7N9 Virus

(2016) Eefje J. A. Schrauwen et al.   JOURNAL OF VIROLOGY

Molecular requirements for a pandemic influenza virus: An acid-stable hemagglutinin protein

(2016) Marion Russier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral factors in influenza pandemic risk assessment

(2016) Marc Lipsitch et al.   eLife

What adaptive changes in hemagglutinin and neuraminidase are necessary for emergence of pandemic influenza virus from its avian precursor?

(2015) A. S. Gambaryan et al.   BIOCHEMISTRY-MOSCOW

H1N1 Swine Influenza Viruses Differ from Avian Precursors by a Higher pH Optimum of Membrane Fusion

(2015) Jan Baumann et al.   JOURNAL OF VIROLOGY

Identification of Stabilizing Mutations in an H5 Hemagglutinin Influenza Virus Protein

(2015) Anthony Hanson et al.   JOURNAL OF VIROLOGY

The soft palate is an important site of adaptation for transmissible influenza viruses

(2015) Seema S. Lakdawala et al.   NATURE

Identification, Characterization, and Natural Selection of Mutations Driving Airborne Transmission of A/H5N1 Virus

(2014) Martin Linster et al.   CELL

Role of receptor binding specificity in influenza A virus transmission and pathogenesis

(2014) M. de Graaf et al.   EMBO JOURNAL

PB2 Mutations D701N and S714R Promote Adaptation of an Influenza H5N1 Virus to a Mammalian Host

(2014) V. Czudai-Matwich et al.   JOURNAL OF VIROLOGY

The Matrix Gene Segment Destabilizes the Acid and Thermal Stability of the Hemagglutinin of Pandemic Live Attenuated Influenza Virus Vaccines

(2014) C. D. O'Donnell et al.   JOURNAL OF VIROLOGY

A Single Amino Acid in the Stalk Region of the H1N1pdm Influenza Virus HA Protein Affects Viral Fusion, Stability and Infectivity

(2014) Christopher R. Cotter et al.   PLoS Pathogens

Receptor binding and pH stability — How influenza A virus hemagglutinin affects host-specific virus infection

(2013) Caroline M. Mair et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mutations in haemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility

(2013) H. Shelton et al.   JOURNAL OF GENERAL VIROLOGY

Hemagglutinin Receptor Specificity and Structural Analyses of Respiratory Droplet-Transmissible H5N1 Viruses

(2013) R. P. de Vries et al.   JOURNAL OF VIROLOGY

The Short Stalk Length of Highly Pathogenic Avian Influenza H5N1 Virus Neuraminidase Limits Transmission of Pandemic H1N1 Virus in Ferrets

(2013) D. Blumenkrantz et al.   JOURNAL OF VIROLOGY

The pH of Activation of the Hemagglutinin Protein Regulates H5N1 Influenza Virus Replication and Pathogenesis in Mice

(2013) H. Zaraket et al.   JOURNAL OF VIROLOGY

Increased Acid Stability of the Hemagglutinin Protein Enhances H5N1 Influenza Virus Growth in the Upper Respiratory Tract but Is Insufficient for Transmission in Ferrets

(2013) H. Zaraket et al.   JOURNAL OF VIROLOGY

Analysis of Adaptation Mutants in the Hemagglutinin of the Influenza A(H1N1)pdm09 Virus

(2013) Alicia Jiménez-Alberto et al.   PLoS One

Influenza HA Subtypes Demonstrate Divergent Phenotypes for Cleavage Activation and pH of Fusion: Implications for Host Range and Adaptation

(2013) Summer E. Galloway et al.   PLoS Pathogens

Functional Balance of the Hemagglutinin and Neuraminidase Activities Accompanies the Emergence of the 2009 H1N1 Influenza Pandemic

(2012) R. Xu et al.   JOURNAL OF VIROLOGY

Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

(2012) Masaki Imai et al.   NATURE

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

Influenza Virus-Mediated Membrane Fusion: Determinants of Hemagglutinin Fusogenic Activity and Experimental Approaches for Assessing Virus Fusion

(2012) Brian S. Hamilton et al.   Viruses-Basel

Enhanced Growth of Influenza Vaccine Seed Viruses in Vero Cells Mediated by Broadening the Optimal pH Range for Virus Membrane Fusion

(2011) S. Murakami et al.   JOURNAL OF VIROLOGY

Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets

(2011) H.-L. Yen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations affecting the stability of the haemagglutinin molecule impair the immunogenicity of live attenuated H3N2 intranasal influenza vaccine candidates lacking NS1

(2011) Sabine Nakowitsch et al.   VACCINE

Acid Stability of the Hemagglutinin Protein Regulates H5N1 Influenza Virus Pathogenicity

(2011) Rebecca M. DuBois et al.   PLoS Pathogens

RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection

(2010) Jan Rehwinkel et al.   CELL

Establishment and Characterization of a Madin-Darby Canine Kidney Reporter Cell Line for Influenza A Virus Assays

(2010) M. J. Hossain et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Thermostability of Subpopulations of H2N3 Influenza Virus Isolates from Mallard Ducks

(2010) N. J. Negovetich et al.   JOURNAL OF VIROLOGY

Amino Acid Residues in the Fusion Peptide Pocket Regulate the pH of Activation of the H5N1 Influenza Virus Hemagglutinin Protein

(2009) M. L. Reed et al.   JOURNAL OF VIROLOGY

The pH of Activation of the Hemagglutinin Protein Regulates H5N1 Influenza Virus Pathogenicity and Transmissibility in Ducks

(2009) M. L. Reed et al.   JOURNAL OF VIROLOGY

Enhancement of the Influenza A Hemagglutinin (HA)-Mediated Cell-Cell Fusion and Virus Entry by the Viral Neuraminidase (NA)

(2009) Bin Su et al.   PLoS One