The microbiota of the respiratory tract: gatekeeper to respiratory health

Development of the Nasopharyngeal Microbiota in Infants with Cystic Fibrosis

(2016) Sabine M. P. J. Prevaes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nasopharyngeal Microbiota, Host Transcriptome, and Disease Severity in Children with Respiratory Syncytial Virus Infection

(2016) Wouter A. A. de Steenhuijsen Piters et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Signaling via pattern recognition receptors NOD2 and TLR2 contributes to immunomodulatory control of lethal pneumovirus infection

(2016) Tyler A. Rice et al.   ANTIVIRAL RESEARCH

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life

(2016) Meghan A. Koch et al.   CELL

Host Selection of Microbiota via Differential Adhesion

(2016) Kirstie McLoughlin et al.   Cell Host & Microbe

Metagenomic analysis of viral genetic diversity in respiratory samples from children with severe acute respiratory infection in China

(2016) Y. Wang et al.   CLINICAL MICROBIOLOGY AND INFECTION

Composition of human faecal microbiota in resistance to Campylobacter infection

(2016) C. Kampmann et al.   CLINICAL MICROBIOLOGY AND INFECTION

Exploring the bacterial assemblages along the human nasal passage

(2016) Melissa L. Wos-Oxley et al.   ENVIRONMENTAL MICROBIOLOGY

Fostering of advanced mutualism with gut microbiota by Immunoglobulin A

(2016) Duncan B. Sutherland et al.   IMMUNOLOGICAL REVIEWS

Human commensals producing a novel antibiotic impair pathogen colonization

(2016) Alexander Zipperer et al.   NATURE

Interactions between the microbiota and pathogenic bacteria in the gut

(2016) Andreas J. Bäumler et al.   NATURE

Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer

(2016) Maria G Dominguez-Bello et al.   NATURE MEDICINE

The maternal microbiota drives early postnatal innate immune development

(2016) M. Gomez de Aguero et al.   SCIENCE

Volatile Compounds Emitted by Pseudomonas aeruginosa Stimulate Growth of the Fungal Pathogen Aspergillus fumigatus

(2016) Benoit Briard et al.   mBio

Corynebacterium accolens Releases Antipneumococcal Free Fatty Acids from Human Nostril and Skin Surface Triacylglycerols

(2016) Lindsey Bomar et al.   mBio

The healthy human microbiome

(2016) Jason Lloyd-Price et al.   Genome Medicine

High Frequency and Diversity of Antimicrobial Activities Produced by Nasal Staphylococcus Strains against Bacterial Competitors

(2016) Daniela Janek et al.   PLoS Pathogens

Staphylococcus aureus Shifts toward Commensalism in Response to Corynebacterium Species

(2016) Matthew M. Ramsey et al.   Frontiers in Microbiology

The microbiota in bronchoalveolar lavage from young children with chronic lung disease includes taxa present in both the oropharynx and nasopharynx

(2016) R. L. Marsh et al.   Microbiome

Comparison of placenta samples with contamination controls does not provide evidence for a distinct placenta microbiota

(2016) Abigail P. Lauder et al.   Microbiome

Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome

(2016) Robert P. Dickson et al.   Nature Microbiology

Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype

(2016) Leopoldo N. Segal et al.   Nature Microbiology

Development of Upper Respiratory Tract Microbiota in Infancy is Affected by Mode of Delivery

(2016) Astrid A.T.M. Bosch et al.   EBioMedicine

Analysis of the association between host genetics, smoking, and sputum microbiota in healthy humans

(2016) Mi Young Lim et al.   Scientific Reports

Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid

(2016) Maria Carmen Collado et al.   Scientific Reports

Personalized Nutrition by Prediction of Glycemic Responses

(2015) David Zeevi et al.   CELL

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development

(2015) Shu Mei Teo et al.   Cell Host & Microbe

High-Resolution Analyses of Overlap in the Microbiota Between Mothers and Their Children

(2015) Melissa Schanche et al.   CURRENT MICROBIOLOGY

Haemophilus influenzae increases the susceptibility and inflammatory response of airway epithelial cells to viral infections

(2015) Fahad Gulraiz et al.   FASEB JOURNAL

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes

(2015) Tiffany C. Scharschmidt et al.   IMMUNITY

Chronic obstructive pulmonary disease and asthma-associated Proteobacteria, but not commensalPrevotellaspp., promote Toll-like receptor 2-independent lung inflammation and pathology

(2015) Jeppe M. Larsen et al.   IMMUNOLOGY

Culture and molecular-based profiles show shifts in bacterial communities of the upper respiratory tract that occur with age

(2015) Jennifer C Stearns et al.   ISME Journal

Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients

(2015) Wouter A A de Steenhuijsen Piters et al.   ISME Journal

Dynamics of the nasal microbiota in infancy: A prospective cohort study

(2015) Moana Mika et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

(2015) Shruti Naik et al.   NATURE

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

The role of the local microbial ecosystem in respiratory health and disease

(2015) Wouter A. A. de Steenhuijsen Piters et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Reply to Keelan and Payne: Microbiota-related pathways for preterm birth

(2015) Daniel B. DiGiulio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Application of a Neutral Community Model To Assess Structuring of the Human Lung Microbiome

(2015) Arvind Venkataraman et al.   mBio

Analysis of the Upper Respiratory Tract Microbiotas as the Source of the Lung and Gastric Microbiotas in Healthy Individuals

(2015) Christine M. Bassis et al.   mBio

Sources of airborne microorganisms in the built environment

(2015) Aaron J. Prussin et al.   Microbiome

Staphylococcus aureus and the ecology of the nasal microbiome

(2015) C. M. Liu et al.   Science Advances

Early Respiratory Microbiota Composition Determines Bacterial Succession Patterns and Respiratory Health in Children

(2014) Giske Biesbroek et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Viral Metagenomics Reveal Blooms of Anelloviruses in the Respiratory Tract of Lung Transplant Recipients

(2014) J. C. Young et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The influence of oral Veillonella species on biofilms formed by Streptococcus species

(2014) Izumi Mashima et al.   ANAEROBE

Detecting Nasopharyngeal Reflux: A Novel pH Probe Technique

(2014) Joseph D. Brunworth et al.   ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY

Reagent and laboratory contamination can critically impact sequence-based microbiome analyses

(2014) Susannah J Salter et al.   BMC BIOLOGY

Human Genetics Shape the Gut Microbiome

(2014) Julia K. Goodrich et al.   CELL

Influenza Promotes Pneumococcal Growth during Coinfection by Providing Host Sialylated Substrates as a Nutrient Source

(2014) Steven J. Siegel et al.   Cell Host & Microbe

Lung development: orchestrating the generation and regeneration of a complex organ

(2014) M. Herriges et al.   DEVELOPMENT

Inflammatory Bowel Disease as a Model for Translating the Microbiome

(2014) Curtis Huttenhower et al.   IMMUNITY

Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis

(2014) Shimpei Kawamoto et al.   IMMUNITY

Biogeography and individuality shape function in the human skin metagenome

(2014) Julia Oh et al.   NATURE

Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

(2014) Kristin Westphalen et al.   NATURE

Lung microbiota promotes tolerance to allergens in neonates via PD-L1

(2014) Eva S Gollwitzer et al.   NATURE MEDICINE

The airway microbiome of intubated premature infants: characteristics and changes that predict the development of bronchopulmonary dysplasia

(2014) Pablo Lohmann et al.   PEDIATRIC RESEARCH

Environmentally Determined Differences in the Murine Lung Microbiota and Their Relation to Alveolar Architecture

(2014) Yeojun Yun et al.   PLoS One

The Placenta Harbors a Unique Microbiome

(2014) K. Aagaard et al.   Science Translational Medicine

The fungal microbiome in chronic rhinosinusitis: richness, diversity, postoperative changes and patient outcomes

(2014) Edward John Cleland et al.   International Forum of Allergy & Rhinology

Exploration of bacterial community classes in major human habitats

(2014) Yanjiao Zhou et al.   GENOME BIOLOGY

Illustrated Review of the Embryology and Development of the Facial Region, Part 1: Early Face and Lateral Nasal Cavities

(2013) P.M. Som et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Increased Risk of Pneumonia and Bronchiolitis after Bacterial Colonization of the Airways as Neonates

(2013) Nadja H. Vissing et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma

(2013) Elena Goleva et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers

(2013) Alison Morris et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Phage-induced diversification improves host evolvability

(2013) Hywel TP Williams   BMC EVOLUTIONARY BIOLOGY

Differences in fungi present in induced sputum samples from asthma patients and non-atopic controls: a community based case control study

(2013) Hugo Cornelis van Woerden et al.   BMC INFECTIOUS DISEASES

Nasal Microenvironments and Interspecific Interactions Influence Nasal Microbiota Complexity and S. aureus Carriage

(2013) Miling Yan et al.   Cell Host & Microbe

Streptococcal co-infection augmentsCandidapathogenicity by amplifying the mucosal inflammatory response

(2013) H. Xu et al.   CELLULAR MICROBIOLOGY

Lung-resident tissue macrophages generate Foxp3+regulatory T cells and promote airway tolerance

(2013) Pejman Soroosh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Influenza A Virus Exacerbates Staphylococcus aureus Pneumonia in Mice by Attenuating Antimicrobial Peptide Production

(2013) Keven M. Robinson et al.   JOURNAL OF INFECTIOUS DISEASES

Bacterial Lipopolysaccharide Inhibits Influenza Virus Infection of Human Macrophages and the Consequent Induction of CD8+ T Cell Immunity

(2013) Kirsty R. Short et al.   Journal of Innate Immunity

Muc5b is required for airway defence

(2013) Michelle G. Roy et al.   NATURE

Control of pathogens and pathobionts by the gut microbiota

(2013) Nobuhiko Kamada et al.   NATURE IMMUNOLOGY

U.S. Outpatient Antibiotic Prescribing, 2010

(2013) Lauri A. Hicks et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interspecies Communication among Commensal and Pathogenic Streptococci

(2013) L. C. Cook et al.   mBio

Bacterial-induced epithelial damage promotes fungal biofilm formation in a sheep model of sinusitis

(2013) Sam Boase et al.   International Forum of Allergy & Rhinology

Whole Blood Gene Expression Profiles to Assess Pathogenesis and Disease Severity in Infants with Respiratory Syncytial Virus Infection

(2013) Asuncion Mejias et al.   PLOS MEDICINE

Viral and Bacterial Interactions in the Upper Respiratory Tract

(2013) Astrid A. T. M. Bosch et al.   PLoS Pathogens

Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation

(2013) Leopoldo N Segal et al.   Microbiome

Lung-enriched Organisms and Aberrant Bacterial and Fungal Respiratory Microbiota after Lung Transplant

(2012) Emily S. Charlson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Upper Respiratory Tract Microbial Communities, Acute Otitis Media Pathogens, and Antibiotic Use in Healthy and Sick Children

(2012) Melinda M. Pettigrew et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Comparisons of clustered regularly interspaced short palindromic repeats and viromes in human saliva reveal bacterial adaptations to salivary viruses

(2012) David T. Pride et al.   ENVIRONMENTAL MICROBIOLOGY

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity

(2012) Michael C. Abt et al.   IMMUNITY

Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms

(2012) J Gregory Caporaso et al.   ISME Journal

Nasopharyngeal Microbiota in Infants With Acute Otitis Media

(2012) Markus Hilty et al.   JOURNAL OF INFECTIOUS DISEASES

Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000

(2012) Li Liu et al.   LANCET

Biodiversity loss and its impact on humanity

(2012) Bradley J. Cardinale et al.   NATURE

Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma

(2012) Nandini Krishnamoorthy et al.   NATURE MEDICINE

Deep Sequencing Analyses of Low Density Microbial Communities: Working at the Boundary of Accurate Microbiota Detection

(2012) Giske Biesbroek et al.   PLoS One

Long-Term Effects of Pneumococcal Conjugate Vaccine on Nasopharyngeal Carriage of S. pneumoniae, S. aureus, H. influenzae and M. catarrhalis

(2012) Judith Spijkerman et al.   PLoS One

Sequence Analysis of the Human Virome in Febrile and Afebrile Children

(2012) Kristine M. Wylie et al.   PLoS One

Pharyngeal Microflora Disruption by Antibiotics Promotes Airway Hyperresponsiveness after Respiratory Syncytial Virus Infection

(2012) Ke Ni et al.   PLoS One

Associations between Pathogens in the Upper Respiratory Tract of Young Children: Interplay between Viruses and Bacteria

(2012) Menno R. van den Bergh et al.   PLoS One

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

Sinus Microbiome Diversity Depletion and Corynebacterium tuberculostearicum Enrichment Mediates Rhinosinusitis

(2012) N. A. Abreu et al.   Science Translational Medicine

Human milk: a source of more life than we imagine

(2012) P.V. Jeurink et al.   Beneficial Microbes

Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples

(2012) Nicola Segata et al.   GENOME BIOLOGY

Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization

(2011) Tina Herbst et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Topographical Continuity of Bacterial Populations in the Healthy Human Respiratory Tract

(2011) Emily S. Charlson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Synergistic Interaction between Candida albicans and Commensal Oral Streptococci in a NovelIn VitroMucosal Model

(2011) Patricia I. Diaz et al.   INFECTION AND IMMUNITY

Spatial distribution of microbial communities in the cystic fibrosis lung

(2011) Dana Willner et al.   ISME Journal

The Airway Antigen Sampling System: Respiratory M Cells as an Alternative Gateway for Inhaled Antigens

(2011) Dong-Young Kim et al.   JOURNAL OF IMMUNOLOGY

The development of inducible bronchus-associated lymphoid tissue depends on IL-17

(2011) Javier Rangel-Moreno et al.   NATURE IMMUNOLOGY

Variability and Diversity of Nasopharyngeal Microbiota in Children: A Metagenomic Analysis

(2011) Debby Bogaert et al.   PLoS One

Molecular Identification of Bacteria in Tracheal Aspirate Fluid from Mechanically Ventilated Preterm Infants

(2011) Peter M. Mourani et al.   PLoS One

Microbiota regulates immune defense against respiratory tract influenza A virus infection

(2011) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial Communities of the Upper Respiratory Tract and Otitis Media in Children

(2011) A. S. Laufer et al.   mBio

A poke into the diversity and associations within human anterior nare microbial communities

(2010) Melissa L Wos-Oxley et al.   ISME Journal

Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization

(2010) Tadayuki Iwase et al.   NATURE

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

Molecular Microbiological Characterization of Preterm Neonates at Risk of Bronchopulmonary Dysplasia

(2010) Matthew S Payne et al.   PEDIATRIC RESEARCH

Prolonged and Exclusive Breastfeeding Reduces the Risk of Infectious Diseases in Infancy

(2010) L. Duijts et al.   PEDIATRICS

Short-Term Antibiotic Treatment Has Differing Long-Term Impacts on the Human Throat and Gut Microbiome

(2010) Hedvig E. Jakobsson et al.   PLoS One

The Human Nasal Microbiota and Staphylococcus aureus Carriage

(2010) Daniel N. Frank et al.   PLoS One

Disordered Microbial Communities in the Upper Respiratory Tract of Cigarette Smokers

(2010) Emily S. Charlson et al.   PLoS One

Vaginal microbiome of reproductive-age women

(2010) J. Ravel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Indirect Pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in Polymicrobial Otitis Media Occurs via Interspecies Quorum Signaling

(2010) C. E. Armbruster et al.   mBio

Influenza Virus Infection Decreases Tracheal Mucociliary Velocity and Clearance ofStreptococcus pneumoniae

(2009) Lynnelle A. Pittet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

Candida albicans impairs macrophage function and facilitates Pseudomonas aeruginosa pneumonia in rat*

(2009) Damien Roux et al.   CRITICAL CARE MEDICINE

A New Technique for Measurement of Pharyngeal pH: Normal Values and Discriminating pH Threshold

(2009) S. Ayazi et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Enteric defensins are essential regulators of intestinal microbial ecology

(2009) Nita H Salzman et al.   NATURE IMMUNOLOGY

Metagenomic Analysis of Respiratory Tract DNA Viral Communities in Cystic Fibrosis and Non-Cystic Fibrosis Individuals

(2009) Dana Willner et al.   PLoS One

Killing niche competitors by remote-control bacteriophage induction

(2009) L. Selva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses

(2009) I. Amit et al.   SCIENCE

Rhinovirus Disrupts the Barrier Function of Polarized Airway Epithelial Cells

(2008) Umadevi Sajjan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sustained desensitization to bacterial Toll-like receptor ligands after resolutionof respiratory influenza infection

(2008) Arnaud Didierlaurent et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoea

(2008) JENNIFER H. WALSH et al.   JOURNAL OF SLEEP RESEARCH

Mucins in the mucosal barrier to infection

(2008) S K Linden et al.   Mucosal Immunology

Inhibition of pulmonary antibacterial defense by interferon-γ during recovery from influenza infection

(2008) Keer Sun et al.   NATURE MEDICINE

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

(2008) Edy Y Kim et al.   NATURE MEDICINE