Article
Cell Biology
Viktor Vedelek, Balazs Vedelek, Peter Lorincz, Gabor Juhasz, Rita Sinka
Summary: This study reveals functional differences between the testis-specific glutamate dehydrogenase Bb8 and the housekeeping Gdh, providing further evidence for their potential convergence in molecular evolution. Additionally, the study highlights the importance of glutamate metabolism in sperm development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
L. Marchi, F. Degola, E. Baruffini, F. M. Restivo
Summary: Plant NADH glutamate dehydrogenase is a complex enzyme with reversible activity, different isoforms, and variable localization, making it challenging to understand its physiological role. Various approaches have been used to study GDH expression in different plant systems and environmental conditions.
Review
Genetics & Heredity
Qiao Zeng, Yan-Mei Sang
Summary: Congenital hyperinsulinism (CHI) is a genetically heterogeneous disease characterized by excessive insulin secretion and increased serum insulin concentration, leading to intractable, persistent hypoglycemia. Glutamate dehydrogenase hyperinsulinism (GDH-HI) is the second most common type of CHI, caused by mutations in the glutamate dehydrogenase 1 gene. This review aims to summarize the genetic mechanisms, diagnosis, and treatment progress of GDH-HI. Early diagnosis and treatment are crucial in preventing long-term neurological complications in children with GDH-HI.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Physiology
Wouter Mes, Philippe Kersten, Roel M. Maas, Ep H. Eding, Mike S. M. Jetten, Henk Siepel, Sebastian Lucker, Marnix Gorissen, Maartje A. H. J. Van Kessel
Summary: Accumulation of ammonia is a challenge in intensive aquaculture, and feeding strategy and dietary protein content can impact fish growth and nitrogen metabolism. Nitrogen cycle bacteria in the gills convert ammonia to N-2 and potentially explain the unaccounted nitrogen in the balance.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biology
Sukkum Ngullie Chang, Seketoulie Keretsu, Sun Chul Kang
Summary: In this study, the researchers identified decursin and decursinol angelate as potential inhibitors of glutamate dehydrogenase (GDH) through molecular docking and molecular dynamics simulation. These compounds showed stable hydrogen bond interactions with GDH and exhibited higher binding energy than the standard GDH inhibitor epigallocatechin gallate. Biochemical analysis confirmed the inhibitory effect and established decursin and decursinol angelate as novel GDH inhibitors.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Geriatrics & Gerontology
Claudia Salcedo, Jens Andersen, Kasper Tore Vinten, Lars H. Pinborg, Helle S. Waagepetersen, Kristine K. Freude, Blanca Aldana
Summary: The study aimed to provide the first functional characterization of BCAA metabolism in human brain tissue and investigate the role of astrocytic and neuronal BCAA metabolism in AD pathophysiology. The findings revealed an active BCAA metabolism in human astrocytes, with impaired leucine metabolism in astrocytes derived from hiPSC models of AD. This impairment may contribute to neurotransmitter and energetic imbalances in the AD brain.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Rossella Menghini, Lesley Hoyles, Marina Cardellini, Viviana Casagrande, Arianna Marino, Paolo Gentileschi, Francesca Davato, Maria Mavilio, Ivan Arisi, Alessandro Mauriello, Manuela Montanaro, Manuel Scimeca, Richard H. Barton, Francesca Rappa, Francesco Cappello, Manlio Vinciguerra, Jose Maria Moreno-Navarrete, Wifredo Ricart, Ottavia Porzio, Jose-Manuel Fernandez-Real, Remy Burcelin, Marc-Emmanuel Dumas, Massimo Federici
Summary: This study identified the downregulation of the ITCH gene in human hepatic tissue associated with the grade of steatosis through integrated analysis of liver transcriptomic and metabolomic data from obese individuals. Further experiments in mouse models confirmed the role of ITCH in fatty liver disease, revealing its regulation of branched-chain amino acid degradation enzymes and the associated elevation of circulating branched-chain amino acids. Restoring ITCH expression in the liver of ITCH knockout mice normalized branched-chain amino acid metabolism.
MOLECULAR METABOLISM
(2022)
Article
Food Science & Technology
Jinnan Song, Jingli Yang, Byoung Ryong Jeong
Summary: This study investigates the effects of silicon on ammonium toxicity in cabbage plants. It found that silicon can alleviate ammonium toxicity by reducing chlorosis, foliage necrosis, and stunted roots. Additionally, silicon mitigates the inhibition of nutrient uptake, restricted photosynthesis, and oxidative stress caused by ammonium toxicity. Furthermore, silicon enhances the activity of key enzymes involved in ammonium assimilation and increases ammonium content in leaves.
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
(2022)
Review
Medicine, General & Internal
Silvia Espina, Alejandro Sanz-Paris, Vanesa Bernal-Monterde, Diego Casas-Deza, Jose Miguel Arbones-Mainar
Summary: BCAA supplementation can slightly increase muscle mass and body mass index, improve symptoms of hepatic encephalopathy, and is indicated as second-line therapy in liver cirrhosis. The effect of HMB supplementation on muscle mass in liver cirrhosis studies has not been clearly demonstrated.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Yasuyuki Kitaura, Daichi Shindo, Tatsuya Ogawa, Ayato Sato, Yoshiharu Shimomura
Summary: Valsartan, an angiotensin II type 1 receptor (AT1R) blocker, has been identified as a novel BDK inhibitor that can increase BCKDH activity by inhibiting phosphorylation and BCKDH-BDK interaction. It competes with ATP through a different mechanism from allosteric inhibitors and has shown potential in preserving cardiac function in heart failure mice and attenuating insulin resistance in obese mice. Valsartan holds promise as a potent seed compound for developing a powerful BDK inhibitor and useful medication for treating heart failure and metabolic diseases with suppressed BCAA catabolism.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Neurosciences
Jens Andersen, Kia H. Markussen, Emil Jakobsen, Arne Schousboe, Helle S. Waagepetersen, Paul A. Rosenberg, Blanca Aldana
Summary: Glutamate plays a crucial role in brain function, with its recycling dependent on metabolic collaboration between neurons and astrocytes. In addition to its involvement in brain energy metabolism, glutamate also serves as a hub connecting glucose and amino acid metabolism, disruptions in which can lead to neuronal excitotoxicity. Understanding the regulation of glutamate-dependent metabolic processes may provide new insights and targets for treating neurodegenerative diseases.
Article
Medicine, General & Internal
Saeideh Hashemi-Hafshejani, Ahmad Reza Meamar, Maryam Moradi, Nasrin Hemmati, Shahram Solaymani-Mohammadi, Elham Razmjou
Summary: The study identified the genetic diversity of G. duodenalis isolates in Tehran using multilocus sequence typing. Assemblages A and B were the main sources of infection in humans, and dual infections with both assemblages were common. Assemblage A isolates showed low genetic polymorphism, while assemblage B isolates had high genetic variations. Further research is needed to determine the specific multilocus genotypes and the transmission modes in different host populations.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Liangshan Mu, Zhenhong Ye, Junhao Hu, Yurong Zhang, Kai Chen, Haipeng Sun, Rong Li, Weian Mao, Xiaoyu Long, Chunmei Zhang, Yuchen Lai, Jun Liu, Yue Zhao, Jie Qiao
Summary: This study found that women with polycystic ovary syndrome (PCOS) have significantly elevated levels of branched chain amino acids (BCAAs), and BCAA metabolism is potentially causally associated with the risk of PCOS. Using animal models and cell experiments, the researchers demonstrated that deficient and suppressed expression of the protein phosphatase PPM1K can lead to BCAA metabolism dysregulation, resulting in the occurrence and development of PCOS.
Article
Hematology
Haojie Jiang, Lin Zhang, Mina Yang, Guoming Li, Chen Ding, Min Xin, Jing Dai, Xueqing Sun, Xuemei Fan, Haipeng Sun, Junling Liu, Yanyan Xu
Summary: This study reveals the important role of BCAAs in megakaryocyte differentiation and platelet production. BCAA diet can promote megakaryocyte differentiation and platelet production, while deficiency in BCAA metabolism leads to thrombocythemia. Activation of BCAA metabolism can reduce thrombocythemia.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Editorial Material
Plant Sciences
Chao-Feng Huang
Summary: Identification of direct targets of STOP1 transcription factor is crucial for understanding Al-induced expression patterns of STOP1-regulated genes. The study demonstrated the necessity of GDH1 and GDH2 for Al resistance, and revealed the involvement of the PI-PLC pathway in regulating STOP1 protein accumulation in response to Al stress. Further exploration of the Al signaling pathway holds promise for enhancing crop resistance to Al stress.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Clinical Neurology
Brittney L. Blevins, Harry V. Vinters, Seth Love, Donna M. Wilcock, Lea T. Grinberg, Julie A. Schneider, Rajesh N. Kalaria, Yuriko Katsumata, Brian T. Gold, Danny J. J. Wang, Samantha J. Ma, Lincoln M. P. Shade, David W. Fardo, Anika M. S. Hartz, Gregory A. Jicha, Karin B. Nelson, Shino D. Magaki, Frederick A. Schmitt, Merilee A. Teylan, Eseosa T. Ighodaro, Panhavuth Phe, Erin L. Abner, Matthew D. Cykowski, Linda J. Van Eldik, Peter T. Nelson
Summary: Brain arteriolosclerosis (B-ASC) is a common finding at autopsy in aged individuals, associated with cognitive impairment, hypertension, and diabetes, and possibly other complex risk factors and pathogenetic mechanisms. It is a complex and under-studied contributor to neurologic disability, with potential interactions between metabolic syndrome and brain arteriolar pathology.
ACTA NEUROPATHOLOGICA
(2021)
Article
Clinical Neurology
Johannes Attems, Jon B. Toledo, Lauren Walker, Ellen Gelpi, Steve Gentleman, Glenda Halliday, Tibor Hortobagyi, Kurt Jellinger, Gabor G. Kovacs, Edward B. Lee, Seth Love, Kirsty E. McAleese, Peter T. Nelson, Manuela Neumann, Laura Parkkinen, Tuomo Polvikoski, Beata Sikorska, Colin Smith, Lea Tenenholz Grinberg, Dietmar R. Thal, John Q. Trojanowski, Ian G. McKeith
Summary: Several staging systems exist for the neuropathological diagnosis of LBD, with varying levels of inter-rater reliability. The LPC system, based on a dichotomous approach for scoring LP, showed good reproducibility and allowed for the classification of all cases into distinct categories. It may serve as a reliable and useful standard future approach for the post-mortem evaluation of LP.
ACTA NEUROPATHOLOGICA
(2021)
Article
Clinical Neurology
Hannah Tayler, J. Scott Miners, Ozge Guzel, Rob MacLachlan, Seth Love
Summary: This study investigated the pathophysiology of vascular dysfunction in VaD, AD, and mixed dementia, finding a correlation between cerebral hypoperfusion, BBB leakiness, and various markers of vascular dysfunction with SVD, Aβ level, plaque load, and Braak tangle stage. Abnormalities in cerebral perfusion and BBB function were largely attributed to arteriolosclerosis, Aβ, tau, and endothelin-related vascular dysfunction, with variations between and within different dementia types.
Article
Clinical Neurology
Kirsty E. McAleese, Sean J. Colloby, Alan J. Thomas, Safa Al-Sarraj, Olaf Ansorge, James Neal, Federico Roncaroli, Seth Love, Paul T. Francis, Johannes Attems
Summary: The aged brain often exhibits multiple pathologies, rather than a single pathology, and the presence of multiple pathologies can significantly worsen cognitive decline, increasing the risk of transitioning from mild cognitive impairment to dementia.
ALZHEIMERS & DEMENTIA
(2021)
Article
Genetics & Heredity
Ruth Chia, Marya S. Sabir, Sara Bandres-Ciga, Sara Saez-Atienzar, Regina H. Reynolds, Emil Gustavsson, Ronald L. Walton, Sarah Ahmed, Coralie Viollet, Jinhui Ding, Mary B. Makarious, Monica Diez-Fairen, Makayla K. Portley, Zalak Shah, Yevgeniya Abramzon, Dena G. Hernandez, Cornelis Blauwendraat, David J. Stone, John Eicher, Laura Parkkinen, Olaf Ansorge, Lorraine Clark, Lawrence S. Honig, Karen Marder, Afina Lemstra, Peter St George-Hyslop, Elisabet Londos, Kevin Morgan, Tammaryn Lashley, Thomas T. Warner, Zane Jaunmuktane, Douglas Galasko, Isabel Santana, Pentti J. Tienari, Liisa Myllykangas, Minna Oinas, Nigel J. Cairns, John C. Morris, Glenda M. Halliday, Vivianna M. Van Deerlin, John Q. Trojanowski, Maurizio Grassano, Andrea Calvo, Gabriele Mora, Antonio Canosa, Gianluca Floris, Ryan C. Bohannan, Francesca Brett, Ziv Gan-Or, Joshua T. Geiger, Anni Moore, Patrick May, Rejko Kruger, David S. Goldstein, Grisel Lopez, Nahid Tayebi, Ellen Sidransky, Lucy Norcliffe-Kaufmann, Jose-Alberto Palma, Horacio Kaufmann, Vikram G. Shakkottai, Matthew Perkins, Kathy L. Newell, Thomas Gasser, Claudia Schulte, Francesco Landi, Erika Salvi, Daniele Cusi, Eliezer Masliah, Ronald C. Kim, Chad A. Caraway, Edwin S. Monuki, Maura Brunetti, Ted M. Dawson, Liana S. Rosenthal, Marilyn S. Albert, Olga Pletnikova, Juan C. Troncoso, Margaret E. Flanagan, Qinwen Mao, Eileen H. Bigio, Eloy Rodriguez-Rodriguez, Jon Infante, Carmen Lage, Isabel Gonzalez-Aramburu, Pascual Sanchez-Juan, Bernardino Ghetti, Julia Keith, Sandra E. Black, Mario Masellis, Ekaterina Rogaeva, Charles Duyckaerts, Alexis Brice, Suzanne Lesage, Georgia Xiromerisiou, Matthew J. Barrett, Bension S. Tilley, Steve Gentleman, Giancarlo Logroscino, Geidy E. Serrano, Thomas G. Beach, Ian G. McKeith, Alan J. Thomas, Johannes Attems, Christopher M. Morris, Laura Palmer, Seth Love, Claire Troakes, Safa Al-Sarraj, Angela K. Hodges, Dag Aarsland, Gregory Klein, Scott M. Kaiser, Randy Woltjer, Pau Pastor, Lynn M. Bekris, James B. Leverenz, Lilah M. Besser, Amanda Kuzma, Alan E. Renton, Alison Goate, David A. Bennett, Clemens R. Scherzer, Huw R. Morris, Raffaele Ferrari, Diego Albani, Stuart Pickering-Brown, Kelley Faber, Walter A. Kukull, Estrella Morenas-Rodriguez, Alberto Lleo, Juan Fortea, Daniel Alcolea, Jordi Clarimon, Mike A. Nalls, Luigi Ferrucci, Susan M. Resnick, Toshiko Tanaka, Tatiana M. Foroud, Neill R. Graff-Radford, Zbigniew K. Wszolek, Tanis Ferman, Bradley F. Boeve, John A. Hardy, Eric J. Topol, Ali Torkamani, Andrew B. Singleton, Mina Ryten, Dennis W. Dickson, Adriano Chio, Owen A. Ross, J. Raphael Gibbs, Clifton L. Dalgard, Bryan J. Traynor, Sonja W. Scholz
Summary: By conducting whole-genome sequencing and genetic analysis, researchers have identified common genetic risk factors and pathways shared between Lewy body dementia, Alzheimer's disease, and Parkinson's disease. This provides a deeper understanding of the complex genetic architecture of these age-related neurodegenerative conditions.
Review
Environmental Sciences
Juana Maria Delgado-Saborit, Valentina Guercio, Alison M. Gowers, Gavin Shaddick, Nick C. Fox, Seth Love
Summary: This review critically examines the epidemiological evidence of associations between exposure to ambient air pollutants and cognitive performance, cognitive decline, and risk of developing dementia. The evidence consistently shows associations between chronic exposure to air pollution and reduced cognitive function, as well as increased risk of cognitive decline and dementia. Neuroimaging studies also report brain structure changes related to air pollution exposure, suggesting a causal relationship between air pollution and cognitive impairment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
Molly Endicott, Michael Jones, Jonathon Hull
Summary: Malignant cells have a proliferative advantage but also possess vulnerabilities related to increased demand for amino acids. Current strategies targeting amino acid dependency, such as using asparaginase, show promise in both preclinical and clinical settings. Overall, understanding the complexity of cancer metabolism and exploiting metabolic vulnerabilities offer potential avenues for improving cancer treatment outcomes.
Review
Clinical Neurology
Robert A. Fisher, J. Scott Miners, Seth Love
Summary: This review discusses the role of cerebrovascular disease in vascular dementia and Alzheimer's disease, focusing on the changes in vascular structure and function and their impact on disease pathology and cognitive decline. It highlights the contribution of cerebral amyloid angiopathy, non-amyloid small vessel disease, abnormalities in the neurovascular unit, and impairment of the blood-brain barrier to the pathogenesis of Alzheimer's disease. Furthermore, it explores how changes in the cerebral vasculature impair Aβ clearance and increase Aβ production.
Article
Genetics & Heredity
Celine Bellenguez, Fahri Kucukali, Iris E. Jansen, Luca Kleineidam, Sonia Moreno-Grau, Najaf Amin, Adam C. Naj, Rafael Campos-Martin, Benjamin Grenier-Boley, Victor Andrade, Peter A. Holmans, Anne Boland, Vincent Damotte, Sven J. van der Lee, Marcos R. Costa, Teemu Kuulasmaa, Qiong Yang, Itziar De Rojas, Joshua C. Bis, Amber Yaqub, Ivana Prokic, Julien Chapuis, Shahzad Ahmad, Vilmantas Giedraitis, Dag Aarsland, Pablo Garcia-Gonzalez, Carla Abdelnour, Emilio Alarcon-Martin, Daniel Alcolea, Montserrat Alegret, Ignacio Alvarez, Victoria Alvarez, Nicola J. Armstrong, Anthoula Tsolaki, Carmen Antunez, Ildebrando Appollonio, Marina Arcaro, Silvana Archetti, Alfonso Arias Pastor, Beatrice Arosio, Lavinia Athanasiu, Henri Bailly, Nerisa Banaj, Miquel Baquero, Sandra Barral, Alexa Beiser, Ana Belen Pastor, Jennifer E. Below, Penelope Benchek, Luisa Benussi, Claudine Berr, Celine Besse, Valentina Bessi, Giuliano Binetti, Alessandra Bizarro, Rafael Blesa, Merce Boada, Eric Boerwinkle, Barbara Borroni, Silvia Boschi, Paola Bossu, Geir Brathen, Jan Bressler, Catherine Bresner, Henry Brodaty, Keeley J. Brookes, Luis Ignacio Brusco, Dolores Buiza-Rueda, Katharina Burger, Vanessa Burholt, William S. Bush, Miguel Calero, Laura B. Cantwell, Genevieve Chene, Jaeyoon Chung, Michael L. Cuccaro, Roberta Cecchetti, Laura Cervera-Carles, Camille Charbonnier, Hung-Hsin Chen, Caterina Chillotti, Simona Ciccone, Jurgen A. H. R. Claassen, Christopher Clark, Elisa Conti, Anais Corma-Gomez, Emanuele Costantini, Carlo Custodero, Delphine Daian, Maria Carolina Dalmasso, Antonio Daniele, Efthimios Dardiotis, Jean-Francois Dartigues, Peter Paul de Deyn, Katia de Paiva Lopes, Lot D. De Witte, Stephanie Debette, Jurgen Deckert, Teodoro del Ser, Nicola Denning, Anita Destefano, Martin Dichgans, Janine Diehl-Schmid, Monica Diez-Fairen, Paolo Dionigi Rossi, Srdjan Djurovic, Emmanuelle Duron, Emrah Duzel, Carole Dufouil, Gudny Eiriksdottir, Sebastiaan Engelborghs, Valentina Escott-Price, Ana Espinosa, Michael Ewers, Kelley M. Faber, Tagliavini Fabrizio, Sune Fallgaard Nielsen, David W. Fardo, Lucia Farotti, Chiara Fenoglio, Marta Fernandez-Fuertes, Raffaele Ferrari, Catarina B. Ferreira, Evelyn Ferri, Bertrand Fin, Peter Fischer, Tormod Fladby, Klaus Fliessbach, Bernard Fongang, Myriam Fornage, Juan Fortea, Tatiana M. Foroud, Silvia Fostinelli, Nick C. Fox, Emlio Franco-Macias, Maria J. Bullido, Ana Frank-Garcia, Lutz Froelich, Brian Fulton-Howard, Daniela Galimberti, Jose Maria Garcia-Alberca, Sebastian Garcia-Madrona, Guillermo Garcia-Ribas, Roberta Ghidoni, Ina Giegling, Giaccone Giorgio, Alison M. Goate, Oliver Goldhardt, Duber Gomez-Fonseca, Antonio Gonzalez-Perez, Caroline Graff, Giulia Grande, Emma Green, Timo Grimmer, Edna Grunblatt, Michelle Grunin, Vilmundur Gudnason, Tamar Guetta-Baranes, Annakaisa Haapasalo, Georgios Hadjigeorgiou, Jonathan L. Haines, Kara L. Hamilton-Nelson, Harald Hampel, Olivier Hanon, John Hardy, Annette M. Hartmann, Lucrezia Hausner, Janet Harwood, Stefanie Heilmann-Heimbach, Seppo Helisalmi, Michael T. Heneka, Isabel Hernandez, Martin J. Herrmann, Per Hoffmann, Clive Holmes, Henne Holstege, Raquel Huerto Vilas, Marc Hulsman, Jack Humphrey, Geert Jan Biessels, Xueqiu Jian, Charlotte Johansson, Gyungah R. Jun, Yuriko Kastumata, John Kauwe, Patrick G. Kehoe, Lena Kilander, Anne Kinhult Stahlbom, Miia Kivipelto, Anne Koivisto, Johannes Kornhuber, Mary H. Kosmidis, Walter A. Kukull, Pavel P. Kuksa, Brian W. Kunkle, Amanda B. Kuzma, Carmen Lage, Erika J. Laukka, Lenore Launer, Alessandra Lauria, Chien-Yueh Lee, Jenni Lehtisalo, Ondrej Lerch, Alberto Lleo, William Longstreth, Oscar Lopez, Adolfo Lopez de Munain, Seth Love, Malin Lowemark, Lauren Luckcuck, Kathryn L. Lunetta, Yiyi Ma, Juan Macias, Catherine A. Macleod, Wolfgang Maier, Francesca Mangialasche, Marco Spallazzi, Marta Marquie, Rachel Marshall, Eden R. Martin, Angel Martin Montes, Carmen Martinez Rodriguez, Carlo Masullo, Richard Mayeux, Simon Mead, Patrizia Mecocci, Miguel Medina, Alun Meggy, Shima Mehrabian, Silvia Mendoza, Manuel Menendez-Gonzalez, Pablo Mir, Susanne Moebus, Merel Mol, Laura Molina-Porcel, Laura Montrreal, Laura Morelli, Fermin Moreno, Kevin Morgan, Thomas Mosley, Markus M. Nothen, Carolina Muchnik, Shubhabrata Mukherjee, Benedetta Nacmias, Tiia Ngandu, Gael Nicolas, Borge G. Nordestgaard, Robert Olaso, Adelina Orellana, Michela Orsini, Gemma Ortega, Alessandro Padovani, Caffarra Paolo, Goran Papenberg, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Gina Peloso, Alba Perez-Cordon, Jordi Perez-Tur, Pierre Pericard, Oliver Peters, Yolande A. L. Pijnenburg, Juan A. Pineda, Gerard Pinol-Ripoll, Laudia Pisanu, Thomas Polak, Julius Popp, Danielle Posthuma, Josef Priller, Raquel Puerta, Olivier Quenez, Ines Quintela, Jesper Qvist Thomassen, Alberto Rabano, Innocenzo Rainero, Farid Rajabli, Inez Ramakers, Luis M. Real, Marcel J. T. Reinders, Christiane Reitz, Dolly Reyes-Dumeyer, Perry Ridge, Steffi Riedel-Heller, Peter Riederer, Natalia Roberto, Eloy Rodriguez-Rodriguez, Arvid Rongve, Irene Rosas Allende, Maitee Rosende-Roca, Jose Luis Royo, Elisa Rubino, Dan Rujescu, Maria Eugenia Saez, Paraskevi Sakka, Ingvild Saltvedt, Maria Bernal Sanchez-Arjona, Florentino Sanchez-Garcia, Pascual Sanchez Juan, Raquel Sanchez-Valle, Sigrid B. Sando, Chloe Sarnowski, Claudia L. Satizabal, Michela Scamosci, Nikolaos Scarmeas, Elio Scarpini, Philip Scheltens, Norbert Scherbaum, Martin Scherer, Matthias Schmid, Anja Schneider, Jonathan M. Schott, Geir Selbaek, Davide Seripa, Manuel Serrano, Jin Sha, Alexey A. Shadrin, Olivia Skrobot, Susan Slifer, Gijsje J. L. Snijders, Hilkka Soininen, Vincenzo Solfrizzi, Alina Solomon, Yeunjoo Song, Sandro Sorbi, Oscar Sotolongo-Grau, Gianfranco Spalletta, Annika Spottke, Alessio Squassina, Eystein Stordal, Juan Pablo Tartan, Lluis Tarraga, Niccolo Tesi, Anbupalam Thalamuthu, Tegos Thomas, Giuseppe Tosto, Latchezar Traykov, Lucio Tremolizzo, Anne Tybjaerg-Hansen, Andre Uitterlinden, Abbe Ullgren, Ingun Ulstein, Sergi Valero, Otto Valladares, Christine Van Broeckhoven, Jeffery Vance, Badri N. Vardarajan, Aad van der Lugt, Jasper Van Dongen, Jeroen van Rooij, John van Swieten, Rik Vandenberghe, Frans Verhey, Jean-Sebastien Vidal, Jonathan Vogelgsang, Martin Vyhnalek, Michael Wagner, David Wallon, Li-San Wang, Ruiqi Wang, Leonie Weinhold, Jens Wiltfang, Gill Windle, Bob Woods, Mary Yannakoulia, Habil Zare, Yi Zhao, Xiaoling Zhang, Congcong Zhu, Miren Zulaica, Lindsay A. Farrer, Bruce M. Psaty, Mohsen Ghanbari, Towfique Raj, Perminder Sachdev, Karen Mather, Frank Jessen, M. Arfan Ikram, Alexandre de Mendonca, Jakub Hort, Magda Tsolaki, Margaret A. Pericak-Vance, Philippe Amouyel, Julie Williams, Ruth Frikke-Schmidt, Jordi Clarimon, Jean-Francois Deleuze, Giacomina Rossi, Sudha Seshadri, Ole A. Andreassen, Martin Ingelsson, Mikko Hiltunen, Kristel Sleegers, Gerard D. Schellenberg, Cornelia M. van Duijn, Rebecca Sims, Wiesje M. van der Flier, Agustin Ruiz, Alfredo Ramirez, Jean-Charles Lambert
Summary: By characterizing the genetic landscape of Alzheimer's disease and related dementias, new loci have been identified and a new genetic risk score associated with the risk of future Alzheimer's disease and dementia has been generated.
Article
Clinical Neurology
Ian Galea, Andrew Durnford, James Glazier, Sophie Mitchell, Suraj Kohli, Lesley Foulkes, Jeanette Norman, Angela Darekar, Seth Love, Diederik O. Bulters, James A. R. Nicoll, Delphine Boche
Summary: Iron deposits in the cortical gray matter after aneurysmal subarachnoid hemorrhage (SAH) and is associated with cognitive outcome. These findings support therapeutic approaches to prevent the permeation of hemoglobin into the cortex after SAH.
Article
Clinical Neurology
Jonathan Blackman, Seth Love, Lindsey Sinclair, Richard Cain, Elizabeth Coulthard
Summary: The study found a relationship between APOE-epsilon 4 and sleep disturbances, potentially through mechanisms independent of AD pathological changes. Evaluating these mechanisms could enhance understanding of pathways related to sleep disturbances and may provide potential targets for treatment.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Gemma Shireby, Emma L. Dempster, Stefania Policicchio, Rebecca G. Smith, Ehsan Pishva, Barry Chioza, Jonathan P. Davies, Joe Burrage, Katie Lunnon, Dorothea Seiler Vellame, Seth Love, Alan Thomas, Keeley Brookes, Kevin Morgan, Paul Francis, Eilis Hannon, Jonathan Mill
Summary: This study identified differences in cortical DNA methylation associated with Alzheimer's disease pathology and found that most of these differences occurred in non-neuronal cells.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Lasse Pihlstrom, Gemma Shireby, Hanneke Geut, Sandra Pilar Henriksen, Annemieke J. M. Rozemuller, Jon-Anders Tunold, Eilis Hannon, Paul Francis, Alan J. Thomas, Seth Love, Jonathan Mill, Wilma D. J. van de Berg, Mathias Toft
Summary: In this study, the authors investigated the role of DNA methylation changes in the pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). They identified differentially methylated genomic loci associated with Lewy pathology, providing insights into novel disease pathways and potential molecular studies of Lewy body pathology.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Clinical Neurology
J. Scott Miners, Robert A. Fisher, Seth Love
Article
Clinical Neurology
Hannah M. Tayler, Robert MacLachlan, Ozge Guzel, J. Scott Miners, Seth Love
Summary: Hypertension in midlife is a modifiable risk factor for dementia, and its relationship with cognitive decline is well-established. However, the connection between late-life hypertension and dementia is less clear. This study aimed to investigate the relationship between blood pressure during late life and markers of Alzheimer's disease, vascular function, and cerebral oxygenation. The findings suggest a complex relationship between late-life blood pressure, disease pathology, and vascular function in dementia.
BRAIN COMMUNICATIONS
(2023)