Endoplasmic Reticulum-associated Degradation (ERAD) and Autophagy Cooperate to Degrade Polymerogenic Mutant Serpins

Neuroserpin Polymers Activate NF-κB by a Calcium Signaling Pathway That Is Independent of the Unfolded Protein Response

(2009) Mark J. Davies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB

(2008) E. Miranda et al.   HUMAN MOLECULAR GENETICS

Polymers and inflammation: disease mechanisms of the serpinopathies

(2008) Bibek Gooptu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

(2008) Masayuki Yamasaki et al.   NATURE

Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans

(2008) C. Yun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequestration of Mutated α1-Antitrypsin into Inclusion Bodies Is a Cell-protective Mechanism to Maintain Endoplasmic Reticulum Function

(2007) Susana Granell et al.   MOLECULAR BIOLOGY OF THE CELL