Glycosylation-directed quality control of protein folding

The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron

(2015) Gregor Habeck et al.   JOURNAL OF CELL BIOLOGY

The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins

(2015) Martin Mehnert et al.   MOLECULAR BIOLOGY OF THE CELL

Mammalian ER mannosidase I resides in quality control vesicles, where it encounters its glycoprotein substrates

(2015) Ron Benyair et al.   MOLECULAR BIOLOGY OF THE CELL

Significance of glycosylation in Notch signaling

(2014) Hideyuki Takeuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mammalian O-Mannosylation Pathway: Glycan Structures, Enzymes, and Protein Substrates

(2014) Jeremy L. Praissman et al.   BIOCHEMISTRY

Key Steps in ERAD of Luminal ER Proteins Reconstituted with Purified Components

(2014) Alexander Stein et al.   CELL

Recent technical developments in the study of ER-associated degradation

(2014) Kunio Nakatsukasa et al.   CURRENT OPINION IN CELL BIOLOGY

Misfolded Proteins Induce Aggregation of the Lectin Yos9

(2014) Melanie H. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step

(2014) Satoshi Ninagawa et al.   JOURNAL OF CELL BIOLOGY

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation

(2014) Devin Dersh et al.   MOLECULAR BIOLOGY OF THE CELL

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

EDEM2 and OS-9 Are Required for ER-Associated Degradation of Non-Glycosylated Sonic Hedgehog

(2014) Hsiang-Yun Tang et al.   PLoS One

Protein O-mannosylation: What we have learned from baker's yeast

(2013) Martin Loibl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Orchestration of secretory protein folding by ER chaperones

(2013) Tali Gidalevitz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

N-linked protein glycosylation in the ER

(2013) Markus Aebi   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ERAD and protein import defects in a sec61 mutant lacking ER-lumenal loop 7

(2013) Thomas Tretter et al.   BMC CELL BIOLOGY

Glycoprotein misfolding in the endoplasmic reticulum: identification of released oligosaccharides reveals a second ER-associated degradation pathway for Golgi-retrieved proteins

(2013) Dominic S. Alonzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded α1-antitrypsin variant

(2013) Tsutomu Fujimori et al.   FEBS Journal

Golgi-situated endoplasmic reticulum α-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with γ-COP

(2013) Shujuan Pan et al.   MOLECULAR BIOLOGY OF THE CELL

Principles of Cotranslational Ubiquitination and Quality Control at the Ribosome

(2013) Stefanie Duttler et al.   MOLECULAR CELL

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane

(2013) Martin Mehnert et al.   NATURE CELL BIOLOGY

Futile Protein Folding Cycles in the ER Are Terminated by the Unfolded Protein O-Mannosylation Pathway

(2013) C. Xu et al.   SCIENCE

Protein Folding in the Endoplasmic Reticulum

(2013) I. Braakman et al.   Cold Spring Harbor Perspectives in Biology

N-Linked Protein Glycosylation in the Endoplasmic Reticulum

(2013) J. Breitling et al.   Cold Spring Harbor Perspectives in Biology

Mechanisms of Sec61/SecY-Mediated Protein Translocation Across Membranes

(2012) Eunyong Park et al.   Annual Review of Biophysics

A Shared Endoplasmic Reticulum-associated Degradation Pathway Involving the EDEM1 Protein for Glycosylated and Nonglycosylated Proteins

(2012) Marina Shenkman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase

(2012) Eric M. Rubenstein et al.   JOURNAL OF CELL BIOLOGY

Unassembled CD147 is an endogenous endoplasmic reticulum–associated degradation substrate

(2012) Ryan E. Tyler et al.   MOLECULAR BIOLOGY OF THE CELL

Cytosolic Entry of Shiga-Like Toxin A Chain from the Yeast Endoplasmic Reticulum Requires Catalytically Active Hrd1p

(2012) Shuyu Li et al.   PLoS One

The Endoplasmic Reticulum-Associated Degradation Pathways of Budding Yeast

(2012) G. Thibault et al.   Cold Spring Harbor Perspectives in Biology

Protein Folding and Quality Control in the ER

(2012) K. Araki et al.   Cold Spring Harbor Perspectives in Biology

The Mammalian Endoplasmic Reticulum-Associated Degradation System

(2012) J. A. Olzmann et al.   Cold Spring Harbor Perspectives in Biology

Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD

(2011) Elena Martinez Benitez et al.   FEBS LETTERS

Characterization of Early EDEM1 Protein Maturation Events and Their Functional Implications

(2011) Taku Tamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system

(2011) Shujuan Pan et al.   MOLECULAR BIOLOGY OF THE CELL

A Complex of Pdi1p and the Mannosidase Htm1p Initiates Clearance of Unfolded Glycoproteins from the Endoplasmic Reticulum

(2011) Robert Gauss et al.   MOLECULAR CELL

X-ray structure of a bacterial oligosaccharyltransferase

(2011) Christian Lizak et al.   NATURE

Superfolder GFP Is Fluorescent in Oxidizing Environments When Targeted via the Sec Translocon

(2011) Deborah E. Aronson et al.   TRAFFIC

Protein Sorting Receptors in the Early Secretory Pathway

(2010) Julia Dancourt et al.   Annual Review of Biochemistry

Retrotranslocation of a Misfolded Luminal ER Protein by the Ubiquitin-Ligase Hrd1p

(2010) Pedro Carvalho et al.   CELL

Participation of lectin chaperones and thiol oxidoreductases in protein folding within the endoplasmic reticulum

(2010) Lori A Rutkevich et al.   CURRENT OPINION IN CELL BIOLOGY

EDEM1 accelerates the trimming of  1,2-linked mannose on the C branch of N-glycans

(2010) N. Hosokawa et al.   GLYCOBIOLOGY

Free Oligosaccharides to Monitor Glycoprotein Endoplasmic Reticulum-associated Degradation inSaccharomyces cerevisiae

(2010) Hiroto Hirayama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modularity of the Hrd1 ERAD complex underlies its diverse client range

(2010) Kazue Kanehara et al.   JOURNAL OF CELL BIOLOGY

Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LSsubstrates

(2010) Riccardo Bernasconi et al.   JOURNAL OF CELL BIOLOGY

Protein O-mannosyltransferases participate in ER protein quality control

(2010) V. Goder et al.   JOURNAL OF CELL SCIENCE

The Endoplasmic Reticulum–associated Degradation of the Epithelial Sodium Channel Requires a Unique Complement of Molecular Chaperones

(2010) Teresa M. Buck et al.   MOLECULAR BIOLOGY OF THE CELL

Structural Basis for Oligosaccharide Recognition of Misfolded Glycoproteins by OS-9 in ER-Associated Degradation

(2010) Tadashi Satoh et al.   MOLECULAR CELL

Cotranslational and Posttranslational N-Glycosylation of Polypeptides by Distinct Mammalian OST Isoforms

(2009) Catalina Ruiz-Canada et al.   CELL

Sec61p is part of the endoplasmic reticulum-associated degradation machinery

(2009) Antje Schäfer et al.   EMBO JOURNAL

The sugar-binding ability of human OS-9 and its involvement in ER-associated degradation

(2009) Kaoru Mikami et al.   GLYCOBIOLOGY

Roles of Protein-disulfide Isomerase-mediated Disulfide Bond Formation of Yeast Mnl1p in Endoplasmic Reticulum-associated Degradation

(2009) Machiko Sakoh-Nakatogawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In VitroAnalysis of Hrd1p-mediated Retrotranslocation of Its Multispanning Membrane Substrate 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase

(2009) Renee M. Garza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human OS-9, a Lectin Required for Glycoprotein Endoplasmic Reticulum-associated Degradation, Recognizes Mannose-trimmedN-Glycans

(2009) Nobuko Hosokawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum

(2009) Simone Clerc et al.   JOURNAL OF CELL BIOLOGY

Intrinsic Conformational Determinants Signal Protein Misfolding to the Hrd1/Htm1 Endoplasmic Reticulum–associated Degradation System

(2009) Wei Xie et al.   MOLECULAR BIOLOGY OF THE CELL

Rad4 Regulates Protein Turnover at a Postubiquitylation Step

(2009) Yue Li et al.   MOLECULAR BIOLOGY OF THE CELL

Usa1 Functions as a Scaffold of the HRD-Ubiquitin Ligase

(2009) Sabine C. Horn et al.   MOLECULAR CELL

Dolichol-phosphate mannose synthase: Structure, function and regulation

(2008) Yusuke Maeda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Dissecting the ER-Associated Degradation of a Misfolded Polytopic Membrane Protein

(2008) Kunio Nakatsukasa et al.   CELL

Getting In and Out from Calnexin/Calreticulin Cycles

(2008) Julio J. Caramelo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human XTP3-B Forms an Endoplasmic Reticulum Quality Control Scaffold with the HRD1-SEL1L Ubiquitin Ligase Complex and BiP

(2008) Nobuko Hosokawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Dual Task for the Xbp1-responsive OS-9 Variants in the Mammalian Endoplasmic Reticulum

(2008) Riccardo Bernasconi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Sec61p in the ER-associated degradation of short-lived transmembrane proteins

(2008) Daniel C. Scott et al.   JOURNAL OF CELL BIOLOGY

Mammalian OS-9 Is Upregulated in Response to Endoplasmic Reticulum Stress and Facilitates Ubiquitination of Misfolded Glycoproteins

(2008) Felicity Alcock et al.   JOURNAL OF MOLECULAR BIOLOGY

Defining the Glycan Destruction Signal for Endoplasmic Reticulum-Associated Degradation

(2008) Erin M. Quan et al.   MOLECULAR CELL

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

(2008) John C. Christianson et al.   NATURE CELL BIOLOGY

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins

(2008) B. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERdj5 Is Required as a Disulfide Reductase for Degradation of Misfolded Proteins in the ER

(2008) R. Ushioda et al.   SCIENCE

Endoplasmic Reticulum (ER) Mannosidase I Is Compartmentalized and Required for N-Glycan Trimming to Man5–6GlcNAc2 in Glycoprotein ER-associated Degradation

(2007) Edward Avezov et al.   MOLECULAR BIOLOGY OF THE CELL