The PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapy

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health

(2015) William H. Chappell et al.   Oncotarget

Pills of PTEN? In and out for tumor suppression

(2013) Antonella Papa et al.   CELL RESEARCH

Alternative splicing of intrinsically disordered regions and rewiring of protein interactions

(2013) Marija Buljan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Intrinsic Disorder-based Protein Interactions and their Modulators

(2013) Vladimir N. Uversky   CURRENT PHARMACEUTICAL DESIGN

Restoration of PTEN activity decreases metastases in an orthotopic model of colon cancer

(2013) Sanjib Chowdhury et al.   JOURNAL OF SURGICAL RESEARCH

PTEN goes paracrine

(2013) Katrin Legg   NATURE CELL BIOLOGY

A new PTEN translational variant

(2013) Meera Swami   NATURE MEDICINE

Regulation of the Tumor Suppressor PTEN through Exosomes: A Diagnostic Potential for Prostate Cancer

(2013) Kathleen Gabriel et al.   PLoS One

Where Is PTEN?

(2013) N. R. Leslie et al.   SCIENCE

A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival

(2013) B. D. Hopkins et al.   SCIENCE

Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility

(2013) Prerna Malaney et al.   Scientific Reports

MoRFpred, a computational tool for sequence-based prediction and characterization of short disorder-to-order transitioning binding regions in proteins

(2012) Fatemeh Miri Disfani et al.   BIOINFORMATICS

Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas

(2012) Piro Lito et al.   CANCER CELL

Post-Translational Modifications of PTEN and their Potential Therapeutic Implications

(2012) G. Singh et al.   CURRENT CANCER DRUG TARGETS

Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks

(2012) Marija Buljan et al.   MOLECULAR CELL

Endogenous viruses: insights into viral evolution and impact on host biology

(2012) Cédric Feschotte et al.   NATURE REVIEWS GENETICS

Alternative translation initiation augments the human mitochondrial proteome

(2012) Lawrence Kazak et al.   NUCLEIC ACIDS RESEARCH

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

(2012) U. Putz et al.   Science Signaling

Protein Folding and Modification in the Mammalian Endoplasmic Reticulum

(2011) Ineke Braakman et al.   Annual Review of Biochemistry

Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320

(2011) A. Bronisz et al.   NATURE CELL BIOLOGY

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Identification of evolutionarily conserved non-AUG-initiated N-terminal extensions in human coding sequences

(2011) Ivaylo P. Ivanov et al.   NUCLEIC ACIDS RESEARCH

ELM--the database of eukaryotic linear motifs

(2011) H. Dinkel et al.   NUCLEIC ACIDS RESEARCH

Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis

(2011) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PONDR-FIT: A meta-predictor of intrinsically disordered amino acids

(2010) Bin Xue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia

(2010) M. Shehata et al.   BLOOD

Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines

(2010) Yu Wang et al.   HUMAN MOLECULAR GENETICS

The PI3K Pathway As Drug Target in Human Cancer

(2010) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer

(2010) Maria H Traka et al.   Molecular Cancer

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

(2010) Konstantinos J. Mavrakis et al.   NATURE CELL BIOLOGY

Dual coding in alternative reading frames correlates with intrinsic protein disorder

(2010) E. Kovacs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ANCHOR: web server for predicting protein binding regions in disordered proteins

(2009) Z. Dosztanyi et al.   BIOINFORMATICS

FoldAmyloid: a method of prediction of amyloidogenic regions from protein sequence

(2009) S. O. Garbuzynskiy et al.   BIOINFORMATICS

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

miR-19 is a key oncogenic component of mir-17-92

(2009) V. Olive et al.   GENES & DEVELOPMENT

Pten in stromal fibroblasts suppresses mammary epithelial tumours

(2009) Anthony J. Trimboli et al.   NATURE

Phosphorylation keeps PTEN phosphatase closed for business

(2009) A. H. Ross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification, analysis, and prediction of protein ubiquitination sites

(2009) Predrag Radivojac et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Prediction of Protein Binding Regions in Disordered Proteins

(2009) Bálint Mészáros et al.   PLoS Computational Biology

The Zyggregator method for predicting protein aggregation propensities

(2008) Gian Gaetano Tartaglia et al.   CHEMICAL SOCIETY REVIEWS

The O-linked N-acetylglucosamine modification in cellular signalling and the immune system. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Alexander Golks et al.   EMBO REPORTS

Prediction of Aggregation-Prone Regions in Structured Proteins

(2008) Gian Gaetano Tartaglia et al.   JOURNAL OF MOLECULAR BIOLOGY

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

(2008) Changchun Xiao et al.   NATURE IMMUNOLOGY

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN

(2008) M. Rahdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TOP-IDP-Scale: A New Amino Acid Scale Measuring Propensity for Intrinsic Disorder

(2008) Andrew Campen et al.   PROTEIN AND PEPTIDE LETTERS

Aggregation Propensity of the Human Proteome

(2008) Elodie Monsellier et al.   PLoS Computational Biology