Sigma-2 ligands induce tumour cell death by multiple signalling pathways

Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

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Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics

(2011) Chun-yang Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site

(2011) Jinbin Xu et al.   Nature Communications

Regulation of cyclin D1 gene expression: Figure 1

(2010) Ini-Isabée Witzel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Autophagy: assays and artifacts

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Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

“Where, O Death, Is Thy Sting?” A Brief Review of Apoptosis Biology

(2010) Andrew H. Wyllie   MOLECULAR NEUROBIOLOGY

Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer

(2010) C Caldon et al.   Cell Division

F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells

(2009) Giuseppe Cassano et al.   CELL CALCIUM

Understanding Autophagy in Cell Death Control

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Sigma-2 Receptor Expression in Bovine Papillomavirus-Associated Urinary Bladder Tumours

(2009) S. Roperto et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma

(2009) Hiroyuki Kashiwagi et al.   Journal of Translational Medicine

Cell-cycle control in the face of damage – a matter of life or death

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