Tissue-specific differentiation of CD8+ resident memory T cells

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

(2021) Els Wauters et al.   CELL RESEARCH

A New Insight into the Potential Role of Tryptophan-Derived AhR Ligands in Skin Physiological and Pathological Processes

(2021) Monika Szelest et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets

(2021) Michael E.B. FitzPatrick et al.   Cell Reports

Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+ T cells

(2021) Anthony Kusnadi et al.   Science Immunology

Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

(2021) Sarah S. Gabriel et al.   IMMUNITY

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

(2021) Susan N. Christo et al.   NATURE IMMUNOLOGY

Asialo GM1-positive liver-resident CD8 T cells that express CD44 and LFA-1 are essential for immune clearance of hepatitis B virus

(2020) Chi-Chang Sung et al.   Cellular & Molecular Immunology

Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy

(2020) J. Justin Milner et al.   IMMUNITY

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing

(2020) Nadia S. Kurd et al.   Science Immunology

Organ-specific isoform selection of fatty acid–binding proteins in tissue-resident lymphocytes

(2020) H. Frizzell et al.   Science Immunology

Peripherally induced brain tissue–resident memory CD8+ T cells mediate protection against CNS infection

(2020) Stina L. Urban et al.   NATURE IMMUNOLOGY

Early precursor T cells establish and propagate T cell exhaustion in chronic infection

(2020) Daniel T. Utzschneider et al.   NATURE IMMUNOLOGY

CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response

(2020) Shannon K. Bromley et al.   Cell Reports

Competition for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche

(2020) Toshiro Hirai et al.   IMMUNITY

Zymosan by-passes the requirement for pulmonary antigen encounter in lung tissue-resident memory CD8+ T cell development

(2019) Irina Caminschi et al.   Mucosal Immunology

Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques

(2019) Karin Dijkman et al.   NATURE MEDICINE

Comparative analysis reveals a role for TGF-β in shaping the residency-related transcriptional signature in tissue-resident memory CD8+ T cells

(2019) Artika P. Nath et al.   PLoS One

Peripheral and systemic antigens elicit an expandable pool of resident memory CD8 + T cells in the bone marrow

(2019) Maria F. Pascutti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD69+ memory T lymphocytes of the bone marrow and spleen express the signature transcripts of tissue-resident memory T lymphocytes

(2019) Francesco Siracusa et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tissue-Resident T Cells and Other Resident Leukocytes

(2019) David Masopust et al.   Annual Review of Immunology

Remembering to remember: T cell memory maintenance and plasticity

(2019) Kyla D Omilusik et al.   CURRENT OPINION IN IMMUNOLOGY

Single-cell analysis reveals T cell infiltration in old neurogenic niches

(2019) Ben W. Dulken et al.   NATURE

Human lung tissue resident memory T cells in health and disease

(2019) Mark E Snyder et al.   CURRENT OPINION IN IMMUNOLOGY

Tissue-Resident Memory T Cells in Cancer Immunosurveillance

(2019) Simone L. Park et al.   TRENDS IN IMMUNOLOGY

Mucosal-Pull Induction of Lung-Resident Memory CD8 T Cells in Parenteral TB Vaccine-Primed Hosts Requires Cognate Antigens and CD4 T Cells

(2019) Siamak Haddadi et al.   Frontiers in Immunology

CD103+Tumor-Resident CD8+T Cells Are Associated with Improved Survival in Immunotherapy-Naïve Melanoma Patients and Expand Significantly During Anti–PD-1 Treatment

(2018) Jarem Edwards et al.   CLINICAL CANCER RESEARCH

Understanding Subset Diversity in T Cell Memory

(2018) Stephen C. Jameson et al.   IMMUNITY

KLRG1 + Effector CD8 + T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity

(2018) Dietmar Herndler-Brandstetter et al.   IMMUNITY

T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells

(2018) Lalit K. Beura et al.   IMMUNITY

Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance

(2018) Thomas Gebhardt et al.   IMMUNOLOGICAL REVIEWS

CXCL17 Chemokine–Dependent Mobilization of CXCR8+CD8+Effector Memory and Tissue-Resident Memory T Cells in the Vaginal Mucosa Is Associated with Protection against Genital Herpes

(2018) Ruchi Srivastava et al.   JOURNAL OF IMMUNOLOGY

Development, Homeostasis, and Functions of Intestinal Intraepithelial Lymphocytes

(2018) Luc Van Kaer et al.   JOURNAL OF IMMUNOLOGY

The TNF Superfamily Molecule LIGHT Promotes the Generation of Circulating and Lung-Resident Memory CD8 T Cells following an Acute Respiratory Virus Infection

(2018) Pritesh Desai et al.   JOURNAL OF IMMUNOLOGY

Pulmonary antigen encounter regulates the establishment of tissue-resident CD8 memory T cells in the lung airways and parenchyma

(2018) Sean R. McMaster et al.   Mucosal Immunology

Tissue-resident memory T cells at the center of immunity to solid tumors

(2018) Derk Amsen et al.   NATURE IMMUNOLOGY

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

(2018) Peter Savas et al.   NATURE MEDICINE

Blimp-1 induces and Hobit maintains the cytotoxic mediator granzyme B in CD8 T cells

(2018) Natasja A.M. Kragten et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Prime-and-Trap Malaria Vaccination To Generate Protective CD8+Liver-Resident Memory T Cells

(2018) Tayla M. Olsen et al.   JOURNAL OF IMMUNOLOGY

Tissue resident memory CD8+ T cells mediate salivary gland damage in a murine model of Sjögren's syndrome

(2018) Cai-Yue Gao et al.   Arthritis & Rheumatology

Memory Inflation Drives Tissue-Resident Memory CD8+ T Cell Maintenance in the Lung After Intranasal Vaccination With Murine Cytomegalovirus

(2018) Kaitlyn M. Morabito et al.   Frontiers in Immunology

Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin

(2018) Simone L. Park et al.   NATURE

Tissue-resident memory T cells populate the human brain

(2018) Joost Smolders et al.   Nature Communications

CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

(2018) Lauren E. Holz et al.   Cell Reports

White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection

(2017) Seong-Ji Han et al.   IMMUNITY

CD49a Expression Defines Tissue-Resident CD8 + T Cells Poised for Cytotoxic Function in Human Skin

(2017) Stanley Cheuk et al.   IMMUNITY

IL-2hightissue-resident T cells in the human liver: Sentinels for hepatotropic infection

(2017) Laura J. Pallett et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Cells in Celiac Disease

(2017) Bana Jabri et al.   JOURNAL OF IMMUNOLOGY

The Chemokine Receptor CXCR3 Promotes CD8+T Cell Accumulation in Uninfected Salivary Glands but Is Not Necessary after Murine Cytomegalovirus Infection

(2017) Sofia Caldeira-Dantas et al.   JOURNAL OF IMMUNOLOGY

Induction of vaginal-resident HIV-specific CD8 T cells with mucosal prime–boost immunization

(2017) H-X Tan et al.   Mucosal Immunology

Intrinsic 4-1BB signals are indispensable for the establishment of an influenza-specific tissue-resident memory CD8 T-cell population in the lung

(2017) A C Zhou et al.   Mucosal Immunology

The transcriptional repressor HIC1 regulates intestinal immune homeostasis

(2017) K Burrows et al.   Mucosal Immunology

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

(2017) Youdong Pan et al.   NATURE

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

(2017) J. Justin Milner et al.   NATURE

Expression and role of VLA-1 in resident memory CD8 T cell responses to respiratory mucosal viral-vectored immunization against tuberculosis

(2017) Siamak Haddadi et al.   Scientific Reports

Local Inflammatory Cues Regulate Differentiation and Persistence of CD8 + Tissue-Resident Memory T Cells

(2017) Tessa Bergsbaken et al.   Cell Reports

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

(2017) Brahma V. Kumar et al.   Cell Reports

TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection

(2017) Saumya Maru et al.   PLoS Pathogens

CD103+ CD8 T Cells in the Toxoplasma-Infected Brain Exhibit a Tissue-Resident Memory Transcriptional Profile

(2017) Tyler A. Landrith et al.   Frontiers in Immunology

Human intrahepatic CD69 + CD8+ T cells have a tissue resident memory T cell phenotype with reduced cytolytic capacity

(2017) Femke Stelma et al.   Scientific Reports

TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment

(2016) Marie Boutet et al.   CANCER RESEARCH

Hallmarks of Tissue-Resident Lymphocytes

(2016) Xiying Fan et al.   CELL

α4 β1 integrin promotes accumulation of tissue-resident memory CD8+ T cells in salivary glands

(2016) Sandra Woyciechowski et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Liver-Resident Memory CD8 + T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

(2016) Daniel Fernandez-Ruiz et al.   IMMUNITY

Distinct recirculation potential of CD69+ CD103− and CD103+ thymic memory CD8+ T cells

(2016) Simone L Park et al.   IMMUNOLOGY AND CELL BIOLOGY

Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection

(2016) Karin Steinbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Specific niches for lung-resident memory CD8 + T cells at the site of tissue regeneration enable CD69-independent maintenance

(2016) Shiki Takamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adhesion- and Degranulation-Promoting Adapter Protein Promotes CD8 T Cell Differentiation and Resident Memory Formation and Function during an Acute Infection

(2016) Jessica K. Fiege et al.   JOURNAL OF IMMUNOLOGY

IL-15–Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells

(2016) Jason M. Schenkel et al.   JOURNAL OF IMMUNOLOGY

Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury

(2016) Rodney M. Ritzel et al.   JOURNAL OF IMMUNOLOGY

Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

(2016) Pleun Hombrink et al.   NATURE IMMUNOLOGY

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

(2016) L. K. Mackay et al.   SCIENCE

A Distinct Lung-Interstitium-Resident Memory CD8 + T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection

(2016) Pavlo Gilchuk et al.   Cell Reports

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

(2015) Elizabeth M. Steinert et al.   CELL

Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans

(2015) Felipe A. Vieira Braga et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Memory CD8+ T cells colocalize with IL-7+ stromal cells in bone marrow and rest in terms of proliferation and transcription

(2015) Özen Sercan Alp et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

(2015) Laura K. Mackay et al.   IMMUNITY

Cutting Edge: CD69 Interference with Sphingosine-1-Phosphate Receptor Function Regulates Peripheral T Cell Retention

(2015) Laura K. Mackay et al.   JOURNAL OF IMMUNOLOGY

Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

(2015) Shruti Naik et al.   NATURE

Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8+ T cells responding to infection

(2015) Tessa Bergsbaken et al.   NATURE IMMUNOLOGY

Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma

(2015) Takeya Adachi et al.   NATURE MEDICINE

Common clonal origin of central and resident memory T cells following skin immunization

(2015) Olivier Gaide et al.   NATURE MEDICINE

The emerging role of resident memory T cells in protective immunity and inflammatory disease

(2015) Chang Ook Park et al.   NATURE MEDICINE

Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells

(2015) Rei Watanabe et al.   Science Translational Medicine

Resident memory T cells in human health and disease

(2015) R. A. Clark   Science Translational Medicine

The Salivary Gland Acts as a Sink for Tissue-Resident Memory CD8 + T Cells, Facilitating Protection from Local Cytomegalovirus Infection

(2015) Jenny Tosca Thom et al.   Cell Reports

Oral Infection Drives a Distinct Population of Intestinal Resident Memory CD8+ T Cells with Enhanced Protective Function

(2014) Brian S. Sheridan et al.   IMMUNITY

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection

(2014) Brian J. Laidlaw et al.   IMMUNITY

Epidermal Th22 and Tc17 Cells Form a Localized Disease Memory in Clinically Healed Psoriasis

(2014) S. Cheuk et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Resident Memory CD8 T Cells Occupy Frontline Niches in Secondary Lymphoid Organs

(2014) J. M. Schenkel et al.   JOURNAL OF IMMUNOLOGY

Persistence of skin-resident memory T cells within an epidermal niche

(2014) A. Zaid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resident memory CD8 T cells trigger protective innate and adaptive immune responses

(2014) J. M. Schenkel et al.   SCIENCE

Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert

(2014) S. Ariotti et al.   SCIENCE

Thymus-resident memory CD8+T cells mediate local immunity

(2013) Maike Hofmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Unique transcriptional profile of liver-resident memory CD8+ T cells induced by immunization with malaria sporozoites

(2013) S-W Tse et al.   GENES AND IMMUNITY

Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus

(2013) Bram Slütter et al.   IMMUNITY

Human CD1c+ Dendritic Cells Drive the Differentiation of CD103+ CD8+ Mucosal Effector T Cells via the Cytokine TGF-β

(2013) Chun I. Yu et al.   IMMUNITY

Transforming Growth Factor-β Signaling Controls the Formation and Maintenance of Gut-Resident Memory T Cells by Regulating Migration and Retention

(2013) Nu Zhang et al.   IMMUNITY

Lung-resident memory CD8 T cells (TRM ) are indispensable for optimal cross-protection against pulmonary virus infection

(2013) Tao Wu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

(2013) Cara N Skon et al.   NATURE IMMUNOLOGY

Sensing and alarm function of resident memory CD8+ T cells

(2013) Jason M Schenkel et al.   NATURE IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Enhanced survival of lung tissue-resident memory CD8+ T cells during infection with influenza virus due to selective expression of IFITM3

(2013) Linda M Wakim et al.   NATURE IMMUNOLOGY

Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues

(2012) K. A. Casey et al.   JOURNAL OF IMMUNOLOGY

The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain

(2012) L. M. Wakim et al.   JOURNAL OF IMMUNOLOGY

Differentially imprinted innate immunity by mucosal boost vaccination determines antituberculosis immune protective outcomes, independent of T-cell immunity

(2012) M Jeyanathan et al.   Mucosal Immunology

A vaccine strategy that protects against genital herpes by establishing local memory T cells

(2012) Haina Shin et al.   NATURE

Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

(2012) Xiaodong Jiang et al.   NATURE

Regulation of innate CD8+ T-cell activation mediated by cytokines

(2012) B. E. Freeman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen

(2012) S. Ariotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation

(2012) L. K. Mackay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Bone Marrow Hosts Polyfunctional Memory CD4+ and CD8+ T Cells with Close Contact to IL-15-Producing Cells

(2011) D. Herndler-Brandstetter et al.   JOURNAL OF IMMUNOLOGY

Dynamic T cell migration program provides resident memory within intestinal epithelium

(2010) David Masopust et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help

(2009) Yusuke Nakanishi et al.   NATURE

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

(2009) Thomas Gebhardt et al.   NATURE IMMUNOLOGY