TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection

Local antigen in nonlymphoid tissue promotes resident memory CD8+T cell formation during viral infection

(2016) Tahsin N. Khan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection

(2016) Karin Steinbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

(2016) Pleun Hombrink et al.   NATURE IMMUNOLOGY

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

(2016) L. K. Mackay et al.   SCIENCE

A Numerically Subdominant CD8 T Cell Response to Matrix Protein of Respiratory Syncytial Virus Controls Infection with Limited Immunopathology

(2016) Jie Liu et al.   PLoS Pathogens

Viral Escape Mutant Epitope Maintains TCR Affinity for Antigen yet Curtails CD8 T Cell Responses

(2016) Shayla K. Shorter et al.   PLoS One

Transcriptional Analysis of T Cells Resident in Human Skin

(2016) Jane Li et al.   PLoS One

Cutting Edge: Resident Memory CD8 T Cells Express High-Affinity TCRs

(2015) Elizabeth L. Frost et al.   JOURNAL OF IMMUNOLOGY

Airway-Resident Memory CD8 T Cells Provide Antigen-Specific Protection against Respiratory Virus Challenge through Rapid IFN-γ Production

(2015) Sean R. McMaster et al.   JOURNAL OF IMMUNOLOGY

Oral Infection Drives a Distinct Population of Intestinal Resident Memory CD8+ T Cells with Enhanced Protective Function

(2014) Brian S. Sheridan et al.   IMMUNITY

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

Immune Subdominant Antigens as Vaccine Candidates againstMycobacterium tuberculosis

(2014) Mark T. Orr et al.   JOURNAL OF IMMUNOLOGY

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation

(2014) B. B. Au-Yeung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lung-resident memory CD8 T cells (TRM ) are indispensable for optimal cross-protection against pulmonary virus infection

(2013) Tao Wu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Induction of Broad Cytotoxic T Cells by Protective DNA Vaccination Against Marburg and Ebola

(2013) Devon J Shedlock et al.   MOLECULAR THERAPY

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

(2013) Cara N Skon et al.   NATURE IMMUNOLOGY

Low-Affinity T Cells Are Programmed to Maintain Normal Primary Responses but Are Impaired in Their Recall to Low-Affinity Ligands

(2013) Karin M. Knudson et al.   Cell Reports

Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells?

(2012) Selena Viganò et al.   Clinical & Developmental Immunology

Molecular Biology, Epidemiology, and Pathogenesis of Progressive Multifocal Leukoencephalopathy, the JC Virus-Induced Demyelinating Disease of the Human Brain

(2012) M. W. Ferenczy et al.   CLINICAL MICROBIOLOGY REVIEWS

CD8 T Cells Recruited Early in Mouse Polyomavirus Infection Undergo Exhaustion

(2012) J. J. Wilson et al.   JOURNAL OF IMMUNOLOGY

Modification of a Tumor Antigen Determinant To Improve Peptide/MHC Stability Is Associated with Increased Immunogenicity and Cross-Priming a Larger Fraction of CD8+ T Cells

(2012) A. M. Watson et al.   JOURNAL OF IMMUNOLOGY

The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain

(2012) L. M. Wakim et al.   JOURNAL OF IMMUNOLOGY

A vaccine strategy that protects against genital herpes by establishing local memory T cells

(2012) Haina Shin et al.   NATURE

Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation

(2012) L. K. Mackay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The immunological synapse: a cause or consequence of T-cell receptor triggering?

(2011) Balbino Alarcón et al.   IMMUNOLOGY

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathogen-Induced Inflammatory Environment Controls Effector and Memory CD8 + T Cell Differentiation

(2011) Joshua J. Obar et al.   JOURNAL OF IMMUNOLOGY

Protective Efficacy of Serially Up-Ranked Subdominant CD8+ T Cell Epitopes against Virus Challenges

(2011) Eung-Jun Im et al.   PLoS Pathogens

T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool

(2010) J. E. Smith-Garvin et al.   BLOOD

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

(2010) L. M. Wakim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic regulation of T-cell costimulation through TCR-CD28 microclusters

(2009) Tadashi Yokosuka et al.   IMMUNOLOGICAL REVIEWS

TLR2 Engagement on CD8 T Cells Enables Generation of Functional Memory Cells in Response to a Suboptimal TCR Signal

(2009) B. C. Mercier et al.   JOURNAL OF IMMUNOLOGY

Programming for CD8 T Cell Memory Development Requires IL-12 or Type I IFN

(2009) Z. Xiao et al.   JOURNAL OF IMMUNOLOGY

Complete but curtailed T-cell response to very low-affinity antigen

(2009) Dietmar Zehn et al.   NATURE

Different T Cell Receptor Signals Determine CD8+ Memory Versus Effector Development

(2009) E. Teixeiro et al.   SCIENCE

Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation

(2009) Weiguo Cui et al.   VACCINE

Memory Inflation during Chronic Viral Infection Is Maintained by Continuous Production of Short-Lived, Functional T Cells

(2008) Christopher M. Snyder et al.   IMMUNITY

Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates

(2008) Surojit Sarkar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combined Anti-CD40 Conditioning and Well-timed Immunization Prolongs CD8+ T Cell Accumulation and Control of Established Brain Tumors

(2008) Christina M. Ryan et al.   JOURNAL OF IMMUNOTHERAPY

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Memory T-lymphocyte survival does not require T-cell receptor expression

(2008) J. Leignadier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA