The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

(2018) Qingsong Gao et al.   Cell Reports

Nuclear F-actin and myosins drive relocalization of heterochromatic breaks

(2018) Christopher P. Caridi et al.   NATURE

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

(2018) Benjamin R. Schrank et al.   NATURE

Long-term dual-color tracking of genomic loci by modified sgRNAs of the CRISPR/Cas9 system

(2016) Shipeng Shao et al.   NUCLEIC ACIDS RESEARCH

Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage

(2015) Ian Gibbs-Seymour et al.   AGING CELL

53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair

(2015) Francisca Lottersberger et al.   CELL

DNA repair defects and genome instability in Hutchinson–Gilford Progeria Syndrome

(2015) Susana Gonzalo et al.   CURRENT OPINION IN CELL BIOLOGY

Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway

(2015) Mengtan Xing et al.   Nature Communications

Interphase phosphorylation of lamin A

(2014) V. Kochin et al.   JOURNAL OF CELL SCIENCE

Systematic identification of pathological lamin A interactors

(2014) Travis A. Dittmer et al.   MOLECULAR BIOLOGY OF THE CELL

The biogenesis of chromosome translocations

(2014) Vassilis Roukos et al.   NATURE CELL BIOLOGY

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining

(2014) Aashish Soni et al.   NUCLEIC ACIDS RESEARCH

The landscape of kinase fusions in cancer

(2014) Nicolas Stransky et al.   Nature Communications

Diverse Mechanisms of Somatic Structural Variations in Human Cancer Genomes

(2013) Lixing Yang et al.   CELL

Single-Cell Dynamics of Genome-Nuclear Lamina Interactions

(2013) Jop Kind et al.   CELL

The cellular etiology of chromosome translocations

(2013) Vassilis Roukos et al.   CURRENT OPINION IN CELL BIOLOGY

A-Type Lamins Maintain the Positional Stability of DNA Damage Repair Foci in Mammalian Nuclei

(2013) Robert Mahen et al.   PLoS One

Spatial Dynamics of Chromosome Translocations in Living Cells

(2013) V. Roukos et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair

(2012) Brandi L. Mahaney et al.   Biochemistry and Cell Biology

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

A dual role for A-type lamins in DNA double-strand break repair

(2011) Abena B. Redwood et al.   CELL CYCLE

XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair

(2011) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-Scale Screen for DNA Methylation-Based Detection Markers for Ovarian Cancer

(2011) Mihaela Campan et al.   PLoS One

Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining

(2011) V. Ropars et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4–ligase IV during chromosomal translocation formation

(2010) Deniz Simsek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70

(2010) C. Boboila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway

(2009) Ignacio Gonzalez-Suarez et al.   EMBO JOURNAL

Identification and analysis of new proteins involved in the DNA damage response network of Fanconi anemia and Bloom syndrome

(2009) Rong Guo et al.   METHODS

Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4

(2009) P.-Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes

(2009) Elsa Callén et al.   MOLECULAR CELL

Mechanisms promoting translocations in editing and switching peripheral B cells

(2009) Jing H. Wang et al.   NATURE

RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability

(2008) D. Xu et al.   GENES & DEVELOPMENT

DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination

(2008) Sonia Franco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Robust single-particle tracking in live-cell time-lapse sequences

(2008) Khuloud Jaqaman et al.   NATURE METHODS