A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction

LEF1 and B9L Shield  -Catenin from Inactivation by Axin, Desensitizing Colorectal Cancer Cells to Tankyrase Inhibitors

(2014) M. de la Roche et al.   CANCER RESEARCH

Testing Models of the APC Tumor Suppressor/β-Catenin Interaction Reshapes Our View of the Destruction Complex in Wnt Signaling

(2014) Robert J. Yamulla et al.   GENETICS

Assemblages: Functional units formed by cellular phase separation

(2014) Jeffrey A. Toretsky et al.   JOURNAL OF CELL BIOLOGY

Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex

(2014) Ezgi Kunttas-Tatli et al.   MOLECULAR BIOLOGY OF THE CELL

Different Roles for the Axin Interactions with the SAMP versus the Second Twenty Amino Acid Repeat of Adenomatous Polyposis Coli

(2014) Jean Schneikert et al.   PLoS One

Organizing Principles of Mammalian Nonsense-Mediated mRNA Decay

(2013) Maximilian Wei-Lin Popp et al.   Annual Review of Genetics

 -Catenin interacts with APC to regulate  -catenin proteolysis and transcriptional repression of Wnt target genes

(2013) S. H. Choi et al.   GENES & DEVELOPMENT

Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance

(2013) S. Nelson et al.   JOURNAL OF CELL SCIENCE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Wnt Stabilization of  -Catenin Reveals Principles for Morphogen Receptor-Scaffold Assemblies

(2013) S.-E. Kim et al.   SCIENCE

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

(2012) Vivian S.W. Li et al.   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

A finger on the pulse of Wnt receptor signaling

(2012) Bryan T MacDonald et al.   CELL RESEARCH

Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization

(2012) David M. Roberts et al.   MOLECULAR BIOLOGY OF THE CELL

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis

(2012) M Christie et al.   ONCOGENE

Kinetic Responses of  -Catenin Specify the Sites of Wnt Control

(2012) A. R. Hernandez et al.   SCIENCE

Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling

(2011) David M. Roberts et al.   MOLECULAR BIOLOGY OF THE CELL

Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin

(2011) Marc Fiedler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled

(2011) C. Mendoza-Topaz et al.   Open Biology

Allele-Specific Expression of APC in Adenomatous Polyposis Families

(2010) Ester Castellsagué et al.   GASTROENTEROLOGY

Activity of the β-catenin phosphodestruction complex at cell–cell contacts is enhanced by cadherin-based adhesion

(2009) Meghan T. Maher et al.   JOURNAL OF CELL BIOLOGY

Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours

(2008) E. M. Kohler et al.   HUMAN MOLECULAR GENETICS

 -Catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours

(2008) E. M. Kohler et al.   HUMAN MOLECULAR GENETICS

APC Is Essential for Targeting Phosphorylated β-Catenin to the SCFβ-TrCP Ubiquitin Ligase

(2008) YunYun Su et al.   MOLECULAR CELL

Recruitment of adenomatous polyposis coli and β-catenin to axin-puncta

(2008) M C Faux et al.   ONCOGENE