HECT Domain-containing E3 Ubiquitin Ligase NEDD4L Negatively Regulates Wnt Signaling by Targeting Dishevelled for Proteasomal Degradation

The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation

(2012) Chenji Wang et al.   BIOCHEMICAL JOURNAL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Down-regulation of Nedd4L is Associated with the Aggressive Progression and Worse Prognosis of Malignant Glioma

(2012) S. He et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Malin Regulates Wnt Signaling Pathway through Degradation of Dishevelled2

(2012) Jaiprakash Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts

(2012) M. Nethe et al.   JOURNAL OF CELL SCIENCE

HECT and RING finger families of E3 ubiquitin ligases at a glance

(2012) M. B. Metzger et al.   JOURNAL OF CELL SCIENCE

Non-canonical ubiquitin-based signals for proteasomal degradation

(2012) Y. Kravtsova-Ivantsiv et al.   JOURNAL OF CELL SCIENCE

The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein

(2012) W. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

Planar Cell Polarity and the Developmental Control of Cell Behavior in Vertebrate Embryos

(2011) John B. Wallingford   Annual Review of Cell and Developmental Biology

Dishevelled 2 Signaling Promotes Self-Renewal and Tumorigenicity in Human Gliomas

(2011) T. Pulvirenti et al.   CANCER RESEARCH

Principles of planar polarity in animal development

(2011) L. V. Goodrich et al.   DEVELOPMENT

Dlg3 Trafficking and Apical Tight Junction Formation Is Regulated by Nedd4 and Nedd4-2 E3 Ubiquitin Ligases

(2011) Claude A. Van Campenhout et al.   DEVELOPMENTAL CELL

Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity

(2011) Ryan S. Gray et al.   DEVELOPMENTAL CELL

Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease

(2011) T. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Respiratory distress and perinatal lethality in Nedd4-2-deficient mice

(2011) Natasha A. Boase et al.   Nature Communications

Phosphopeptide Screen Uncovers Novel Phosphorylation Sites of Nedd4-2 That Potentiate Its Inhibition of the Epithelial Na+Channel

(2010) Kenneth R. Hallows et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Dact1 Disrupts Planar Cell Polarity Signaling by Altering Dishevelled Activity and Leads to Posterior Malformation in Mice

(2010) Jun Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

(2010) Chan Gao et al.   NATURE CELL BIOLOGY

Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

(2009) B Yang et al.   CELL DEATH AND DIFFERENTIATION

Dishevelled: The hub of Wnt signaling

(2009) Chan Gao et al.   CELLULAR SIGNALLING

N- and E-cadherins in Xenopus are specifically required in the neural and non-neural ectoderm, respectively, for F-actin assembly and morphogenetic movements

(2009) S. Nandadasa et al.   DEVELOPMENT

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

The Ubiquitin Ligase Nedd4-1 Is Required for Heart Development and Is a Suppressor of Thrombospondin-1

(2009) Fatemeh Fouladkou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β Signaling

(2009) Sheng Gao et al.   MOLECULAR CELL

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of ciliary polarity by the APC/C

(2009) A. Ganner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Down-Regulating Destruction: Phosphorylation Regulates the E3 Ubiquitin Ligase Nedd4-2

(2009) P. M. Snyder   Science Signaling

Planar Cell Polarity Signaling: From Fly Development to Human Disease

(2008) Matias Simons et al.   Annual Review of Genetics

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

(2008) G Melino et al.   CELL DEATH AND DIFFERENTIATION

Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia

(2008) X.Y. Hu et al.   EJSO

Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling

(2008) X. R. Cao et al.   Science Signaling