Exploring the aging effect of the anticancer drugs doxorubicin and mitoxantrone on cardiac mitochondrial proteome using a murine model

Fenofibrate attenuates doxorubicin-induced cardiac dysfunction in mice via activating the eNOS/EPC pathway

(2021) Wen-Pin Huang et al.   Scientific Reports

Inflammation as a Possible Trigger for Mitoxantrone-Induced Cardiotoxicity: An In Vivo Study in Adult and Infant Mice

(2021) Ana Reis-Mendes et al.   Pharmaceuticals

MiR-526b-3p mediates doxorubicin-induced cardiotoxicity by targeting STAT3 to inactivate VEGFA

(2020) Lifu Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitoxantrone impairs proteasome activity and prompts early energetic and proteomic changes in HL-1 cardiomyocytes at clinically relevant concentrations

(2020) Vera Marisa Costa et al.   ARCHIVES OF TOXICOLOGY

Effect of standard low-dose anthracycline chemotherapy on late congestive heart failure in breast cancer survivors aged between 50 and 59 at diagnosis: A nationwide study

(2020) Il Yong Chung et al.   BREAST

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Doxorubicin Exposure Causes Subacute Cardiac Atrophy Dependent on the Striated Muscle–Specific Ubiquitin Ligase MuRF1

(2019) Monte S. Willis et al.   Circulation-Heart Failure

Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin—Integration and Visualization of Multi-Omics Data

(2018) Gustav Holmgren et al.   TOXICOLOGICAL SCIENCES

Influence of PARP-1 inhibition in the cardiotoxicity of the topoisomerase 2 inhibitors doxorubicin and mitoxantrone

(2018) Roberto Marques Damiani et al.   TOXICOLOGY IN VITRO

Exercise Training Impacts Cardiac Mitochondrial Proteome Remodeling in Murine Urothelial Carcinoma

(2018) Rita Ferreira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ginsenoside Rg1 Prevents Doxorubicin-Induced Cardiotoxicity through the Inhibition of Autophagy and Endoplasmic Reticulum Stress in Mice

(2018) Zhi-Meng Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Spinochrome D Attenuates Doxorubicin-Induced Cardiomyocyte Death via Improving Glutathione Metabolism and Attenuating Oxidative Stress

(2018) Chang Yoon et al.   Marine Drugs

Exploring the Role of Autophagy-Related Gene 5 (ATG5) Yields Important Insights Into Autophagy in Autoimmune/Autoinflammatory Diseases

(2018) Xin Ye et al.   Frontiers in Immunology

Involvement of oxidative modification of proteins related to ATP synthesis in the left ventricles of hamsters with cardiomyopathy

(2017) Sahoko Ichihara et al.   Scientific Reports

Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue

(2017) Kerstin Boengler et al.   Journal of Cachexia Sarcopenia and Muscle

Aging, Metabolism, and Cancer Development: from Peto’s Paradox to the Warburg Effect

(2017) Tia R. Tidwell et al.   Aging and Disease

Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic ProfilesNovelty and Significance

(2016) Srinivas Ayyadevara et al.   HYPERTENSION

Men and mice: Relating their ages

(2016) Sulagna Dutta et al.   LIFE SCIENCES

Cardiac cytochrome c and cardiolipin depletion during anthracycline-induced chronic depression of mitochondrial function

(2016) Gonçalo C. Pereira et al.   MITOCHONDRION

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Drug-induced mitochondrial dysfunction and cardiotoxicity

(2015) Zoltán V Varga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Role of the Metabolism of Anticancer Drugs in Their Induced-Cardiotoxicity

(2015) Ana Filipa Reis-Mendes et al.   CURRENT DRUG METABOLISM

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore

(2015) Santhanam Shanmughapriya et al.   MOLECULAR CELL

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(2015) Enkui Hao et al.   MOLECULAR MEDICINE

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

(2015) Sarah E. Calvo et al.   NUCLEIC ACIDS RESEARCH

Detailed Analysis of the Human Mitochondrial Contact Site Complex Indicate a Hierarchy of Subunits

(2015) Christine Ott et al.   PLoS One

Proteomic analysis and functional characterization of mouse brain mitochondria during aging reveal alterations in energy metabolism

(2015) Kelly L. Stauch et al.   PROTEOMICS

The age factor for mitoxantrone’s cardiotoxicity: Multiple doses render the adult mouse heart more susceptible to injury

(2015) José Luís Dores-Sousa et al.   TOXICOLOGY

FactoMineR: AnRPackage for Multivariate Analysis

(2015) Sébastien Lê et al.   Journal of Statistical Software

Mitochondrial Topoisomerase I (Top1mt) Is a Novel Limiting Factor of Doxorubicin Cardiotoxicity

(2014) S. Khiati et al.   CLINICAL CANCER RESEARCH

Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment

(2014) Y. Zhao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

(2014) Yoshihiko Ichikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Lifelong Exercise Training Modulates Cardiac Mitochondrial Phosphoproteome in Rats

(2014) Rita Ferreira et al.   JOURNAL OF PROTEOME RESEARCH

Metabolomics Data Normalization with EigenMS

(2014) Yuliya V. Karpievitch et al.   PLoS One

Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers

(2014) Chancievan Thangaratnarajah et al.   Nature Communications

Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Energetic Impairment

(2013) Luciana Grazziotin Rossato et al.   Cardiovascular Toxicology

Therapeutic Concentrations of Mitoxantrone Elicit Energetic Imbalance in H9c2 Cells as an Earlier Event

(2013) Luciana Grazziotin Rossato et al.   Cardiovascular Toxicology

Citric Acid Cycle and Role of its Intermediates in Metabolism

(2013) Muhammad Akram   CELL BIOCHEMISTRY AND BIOPHYSICS

Cardiac Metabolism in Heart Failure

(2013) Torsten Doenst et al.   CIRCULATION RESEARCH

Topoisomerase 2β: A Promising Molecular Target for Primary Prevention of Anthracycline-Induced Cardiotoxicity

(2013) P Vejpongsa et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mass spectrometry-based proteomics: existing capabilities and future directions

(2012) Thomas E. Angel et al.   CHEMICAL SOCIETY REVIEWS

The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy

(2012) Yu Lei et al.   IMMUNITY

Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects

(2012) Steen Larsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cardiac phosphoproteome reveals cell signaling events involved in doxorubicin cardiotoxicity

(2012) Séverine Gratia et al.   Journal of Proteomics

Cardiac angiogenic imbalance leads to peripartum cardiomyopathy

(2012) Ian S. Patten et al.   NATURE

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

OXPHOS susceptibility to oxidative modifications: The role of heart mitochondrial subcellular location

(2011) Ana Isabel Padrão et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity

(2011) Lei Xi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Analysis of proteome changes in doxorubicin-treated adult rat cardiomyocyte

(2011) Suresh N. Kumar et al.   Journal of Proteomics

MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization

(2011) Alwaleed K. Alkhaja et al.   MOLECULAR BIOLOGY OF THE CELL

MISC-1/OGC Links Mitochondrial Metabolism, Apoptosis and Insulin Secretion

(2011) Marco Gallo et al.   PLoS One

Mitochondria and the aging heart

(2011) Chaudhary Ketul R et al.   Journal of Geriatric Cardiology

Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in mice

(2010) Kaushik Vedam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV

(2010) Qian Han et al.   BIOSCIENCE REPORTS

Juvenile Exposure to Anthracyclines Impairs Cardiac Progenitor Cell Function and Vascularization Resulting in Greater Susceptibility to Stress-Induced Myocardial Injury in Adult Mice

(2010) Chengqun Huang et al.   CIRCULATION

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

(2010) Graham M. Strub et al.   FASEB JOURNAL

Measuring adriamycin-induced cardiac hemodynamic dysfunction with a proteomics approach

(2010) Yan Cui et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Enzymology of the branched-chain amino acid oxidation disorders: the valine pathway

(2010) Ronald J. A. Wanders et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results

(2010) Ronald J. A. Wanders et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy

(2010) Rui A. Carvalho et al.   TOXICOLOGY

Mitochondrial dysfunction is associated with a pro-apoptotic cellular environment in senescent cardiac muscle

(2009) Vladimir Ljubicic et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial DNA is a direct target of anti-cancer anthracycline drugs

(2008) Neil Ashley et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Solution Structure of the Integral Human Membrane Protein VDAC-1 in Detergent Micelles

(2008) S. Hiller et al.   SCIENCE

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL