Ginsenoside Rg1 Prevents Doxorubicin-Induced Cardiotoxicity through the Inhibition of Autophagy and Endoplasmic Reticulum Stress in Mice

Eat it right: ER-phagy and recovER-phagy

(2018) Marisa Loi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial calcium uniporter inhibition provides cardioprotection in pressure overload-induced heart failure through autophagy enhancement

(2018) Ziqing Yu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Diazoxide Improves Mitochondrial Connexin 43 Expression in a Mouse Model of Doxorubicin-Induced Cardiotoxicity

(2018) Michela Pecoraro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network

(2018) Shuliang Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardioprotective effects of autophagy: Eat your heart out, heart failure!

(2018) Gaetano Santulli   Science Translational Medicine

ER-phagy at a glance

(2018) Paolo Grumati et al.   JOURNAL OF CELL SCIENCE

Inhibiting Receptor of Advanced Glycation End Products Attenuates Pressure Overload-Induced Cardiac Dysfunction by Preventing Excessive Autophagy

(2018) Wenbin Gao et al.   Frontiers in Physiology

ER homeostasis and autophagy

(2017) Matthew Smith et al.   Essays in Biochemistry

Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress

(2017) Angela Lombardi et al.   JOURNAL OF AUTOIMMUNITY

Crosstalk of ER stress-mediated autophagy and ER-phagy: Involvement of UPR and the core autophagy machinery

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

LCZ696 improves cardiac function via alleviating Drp1-mediated mitochondrial dysfunction in mice with doxorubicin-induced dilated cardiomyopathy

(2017) Yan Xia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Salvianolic acid B attenuates doxorubicin-induced ER stress by inhibiting TRPC3 and TRPC6 mediated Ca 2+ overload in rat cardiomyocytes

(2017) Rong-chang Chen et al.   TOXICOLOGY LETTERS

Oral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis

(2017) Chen Zhu et al.   Oncotarget

Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity

(2017) Navid Koleini et al.   Oncotarget

Chemical Endoplasmic Reticulum Chaperone Alleviates Doxorubicin-Induced Cardiac DysfunctionNovelty and Significance

(2016) Hai Ying Fu et al.   CIRCULATION RESEARCH

Inhibition of TNF-α–mediated NF-κB Activation by Ginsenoside Rg1 Contributes the Attenuation of Cardiac Hypertrophy Induced by Abdominal Aorta Coarctation

(2016) Futian Tang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Ginsenoside Rg1 ameliorates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress-induced apoptosis in a streptozotocin-induced diabetes rat model

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Rg1 prevents myocardial hypoxia/reoxygenation injury by regulating mitochondrial dynamics imbalance via modulation of glutamate dehydrogenase and mitofusin 2

(2016) Gengting Dong et al.   MITOCHONDRION

ER stress: Autophagy induction, inhibition and selection

(2015) Harun-Or Rashid et al.   Autophagy

Autophagy and oxidative stress in cardiovascular diseases

(2015) Yu Mei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Rg1 exhibits neuroprotective effects by inhibiting the endoplasmic reticulum stress-mediated c-Jun N-terminal protein kinase apoptotic pathway in a rat model of Alzheimer's disease

(2015) JUN-SHAN MU et al.   Molecular Medicine Reports

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

Mitochondrial calcium overload is a key determinant in heart failure

(2015) Gaetano Santulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway

(2014) Zhao V. Wang et al.   CELL

Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells

(2014) XIU CHENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Aldehyde dehydrogenase 2 ameliorates doxorubicin-induced myocardial dysfunction through detoxification of 4-HNE and suppression of autophagy

(2014) Aijun Sun et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Ginsenoside Rg1 Prevents Transverse Aortic Constriction–Induced Left Ventricular Hypertrophy and Cardiac Dysfunction by Inhibiting Fibrosis and Enhancing Angiogenesis

(2013) Yao-Jun Zhang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathy

(2013) Filipa S. Carvalho et al.   MEDICINAL RESEARCH REVIEWS

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

IRE1: ER stress sensor and cell fate executor

(2013) Yani Chen et al.   TRENDS IN CELL BIOLOGY

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

(2012) Yanti Octavia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ginsenoside Rg1 inhibits autophagy in H9c2 cardiomyocytes exposed to hypoxia/reoxygenation

(2012) Zi-Long Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A review of the mammalian unfolded protein response

(2011) Anirikh Chakrabarti et al.   BIOTECHNOLOGY AND BIOENGINEERING

Regulation of AKT Phosphorylation at Ser473 and Thr308 by Endoplasmic Reticulum Stress Modulates Substrate Specificity in a Severity Dependent Manner

(2011) Hong Wa Yung et al.   PLoS One

Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum

(2011) M. H. Smith et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Transcription Factor GATA4 Inhibits Doxorubicin-induced Autophagy and Cardiomyocyte Death

(2009) Satoru Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination of Growth and Endoplasmic Reticulum Stress Signaling by Regulator of Calcineurin 1 (RCAN1), a Novel ATF6-inducible Gene

(2008) Peter J. Belmont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY