eIF2-dependent translation initiation: Memory consolidation and disruption in Alzheimer’s disease

Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease

(2021) Mauricio M. Oliveira et al.   Science Signaling

Genetic removal of p70 S6K1 corrects coding sequence length-dependent alterations in mRNA translation in fragile X syndrome mice

(2021) Sameer Aryal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model

(2021) Megan K. Elder et al.   Communications Biology

Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation

(2020) Prerana Shrestha et al.   NATURE NEUROSCIENCE

Monosomes actively translate synaptic mRNAs in neuronal processes

(2020) Anne Biever et al.   SCIENCE

FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism

(2020) Sneha Shah et al.   Cell Reports

The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition

(2020) Beatriz Alvarez-Castelao et al.   eLife

Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention

(2020) Chiara Lanzillotta et al.   PROGRESS IN NEUROBIOLOGY

eIF2α controls memory consolidation via excitatory and somatostatin neurons

(2020) Vijendra Sharma et al.   NATURE

FMRP links optimal codons to mRNA stability in neurons

(2020) Huan Shu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecule cognitive enhancer reverses age-related memory decline in mice

(2020) Karen Krukowski et al.   eLife

eIF2B activator prevents neurological defects caused by a chronic integrated stress response

(2019) Yao Liang Wong et al.   eLife

Widespread Alterations in Translation Elongation in the Brain of Juvenile Fmr1 Knockout Mice

(2019) Sohani Das Sharma et al.   Cell Reports

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Glutamate receptor trafficking and protein synthesis mediate the facilitation of ltp by secreted amyloid precursor protein-alpha

(2019) Bruce G. Mockett et al.   JOURNAL OF NEUROSCIENCE

PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions

(2019) Marion Tible et al.   AGING CELL

Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments

(2019) Anne-Sophie Hafner et al.   SCIENCE

A genetically encodable cell-type-specific protein synthesis inhibitor

(2019) Maximilian Heumüller et al.   NATURE METHODS

The neurobiological foundation of memory retrieval

(2019) Paul W. Frankland et al.   NATURE NEUROSCIENCE

Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome

(2019) Ping Jun Zhu et al.   SCIENCE

Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy

(2019) Sarah Gourmaud et al.   BRAIN

Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala

(2019) Linnaea E Ostroff et al.   eLife

Activating Transcription Factor 4 (ATF4) regulates neuronal activity by controlling GABABR trafficking

(2018) Carlo Corona et al.   JOURNAL OF NEUROSCIENCE

The role of engram cells in the systems consolidation of memory

(2018) Susumu Tonegawa et al.   NATURE REVIEWS NEUROSCIENCE

C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation

(2018) Weiwei Cheng et al.   Nature Communications

A CREB2-targeting microRNA is required for long-term memory after single-trial learning

(2018) Sergei A. Korneev et al.   Scientific Reports

Cannabinoid Modulation of Eukaryotic Initiation Factors (eIF2α and eIF2B1) and Behavioral Cross-Sensitization to Cocaine in Adolescent Rats

(2018) Philippe A. Melas et al.   Cell Reports

Translational Control in the Brain in Health and Disease

(2018) Wayne S. Sossin et al.   Cold Spring Harbor Perspectives in Biology

The AMPA Receptor Code of Synaptic Plasticity

(2018) Graham H. Diering et al.   NEURON

Towards an Understanding of Synapse Formation

(2018) Thomas C. Südhof   NEURON

Active presynaptic ribosomes in the mammalian brain, and altered transmitter release after protein synthesis inhibition

(2018) Matthew S Scarnati et al.   eLife

Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties

(2017) Vijendra Sharma et al.   JOURNAL OF NEUROSCIENCE

Integration of optogenetics with complementary methodologies in systems neuroscience

(2017) Christina K. Kim et al.   NATURE REVIEWS NEUROSCIENCE

Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome

(2017) Sophie R. Thomson et al.   NEURON

Dynamic Axonal Translation in Developing and Mature Visual Circuits

(2016) Toshiaki Shigeoka et al.   CELL

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release

(2016) Thomas J. Younts et al.   NEURON

Translation dynamics of single mRNAs in live cells and neurons

(2016) B. Wu et al.   SCIENCE

Activating Transcription Factor 4 (ATF4) modulates Rho GTPase levels and function via regulation of RhoGDIα

(2016) Silvia Pasini et al.   Scientific Reports

A small molecule targeting protein translation does not rescue spatial learning and memory deficits in the hAPP-J20 mouse model of Alzheimer’s disease

(2016) Erik C.B. Johnson et al.   PeerJ

cJun and CREB2 in the Postsynaptic Neuron Contribute to Persistent Long-Term Facilitation at a Behaviorally Relevant Synapse

(2015) J.-Y. Hu et al.   JOURNAL OF NEUROSCIENCE

Memory Retrieval Requires Ongoing Protein Synthesis and NMDA Receptor Activity-Mediated AMPA Receptor Trafficking

(2015) J. Lopez et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism

(2015) K. M. Huber et al.   JOURNAL OF NEUROSCIENCE

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Optogenetics: 10 years of microbial opsins in neuroscience

(2015) Karl Deisseroth   NATURE NEUROSCIENCE

Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes

(2015) Mychael V. Lourenco et al.   PROGRESS IN NEUROBIOLOGY

Mutations in a translation initiation factor identify the target of a memory-enhancing compound

(2015) Y. Sekine et al.   SCIENCE

Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase

(2015) Meng S. Choy et al.   Cell Reports

Specific Downregulation of Hippocampal ATF4 Reveals a Necessary Role in Synaptic Plasticity and Memory

(2015) Silvia Pasini et al.   Cell Reports

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

(2015) Carmela Sidrauski et al.   eLife

Translational Control in Synaptic Plasticity and Cognitive Dysfunction

(2014) Shelly A. Buffington et al.   Annual Review of Neuroscience

Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions

(2014) Jimena Baleriola et al.   CELL

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α

(2014) Gonzalo Viana Di Prisco et al.   NATURE NEUROSCIENCE

Activating transcription factor 4 (ATF4) modulates post-synaptic development and dendritic spine morphology

(2014) Jin Liu et al.   Frontiers in Cellular Neuroscience

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

DREADDs: novel tools for drug discovery and development

(2013) Hyeong-Min Lee et al.   DRUG DISCOVERY TODAY

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

(2013) Tao Ma et al.   NATURE NEUROSCIENCE

Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory

(2013) Mimi A. Trinh et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

A Role for Neuronal piRNAs in the Epigenetic Control of Memory-Related Synaptic Plasticity

(2012) Priyamvada Rajasethupathy et al.   CELL

Exaggerated translation causes synaptic and behavioural aberrations associated with autism

(2012) Emanuela Santini et al.   NATURE

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

(2012) Julie A. Moreno et al.   NATURE

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

(2012) Mimi A. Trinh et al.   Cell Reports

Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition

(2011) Ping Jun Zhu et al.   CELL

Activation of PKR Causes Amyloid ß-Peptide Accumulation via De-Repression of BACE1 Expression

(2011) Gerard ILL-Raga et al.   PLoS One

The Cell Biology of Synaptic Plasticity

(2011) V. M. Ho et al.   SCIENCE

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation

(2010) Joseph Tcherkezian et al.   CELL

eIF2  Phosphorylation-Dependent Translation in CA1 Pyramidal Cells Impairs Hippocampal Memory Consolidation without Affecting General Translation

(2010) Z. Jiang et al.   JOURNAL OF NEUROSCIENCE

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HCV-NS3 inhibitors: Determination of their kinetic parameters and mechanism

(2009) María Victoria Flores et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Persistent Transcription- and Translation-Dependent Long-Term Potentiation Induced by mGluR1 in Hippocampal Interneurons

(2009) I. Ran et al.   JOURNAL OF NEUROSCIENCE

Rapid Translation of Arc/Arg3.1 Selectively Mediates mGluR-Dependent LTD through Persistent Increases in AMPAR Endocytosis Rate

(2008) Maggie W. Waung et al.   NEURON