Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia

(2019) Sylvia E. Perez et al.   ACTA NEUROPATHOLOGICA

Temporal lobe epilepsy is associated with distinct cognitive phenotypes

(2019) Kathleen H. Elverman et al.   EPILEPSY & BEHAVIOR

Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy

(2018) Delia M. Talos et al.   ANNALS OF NEUROLOGY

A role for astrocyte-derived amyloid β peptides in the degeneration of neurons in an animal model of temporal lobe epilepsy

(2018) A. Kodam et al.   BRAIN PATHOLOGY

A bidirectional association between cognitive ability in young adulthood and epilepsy: a population-based cohort study

(2018) Merete Osler et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Enfermedad de Alzheimer de inicio precoz y de inicio tardío: ¿son la misma entidad?

(2018) P. Tellechea et al.   NEUROLOGIA

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau

(2018) Cara L. Croft et al.   PLoS One

Modulation of Tau Isoforms Imbalance Precludes Tau Pathology and Cognitive Decline in a Mouse Model of Tauopathy

(2018) Sonia Lorena Espíndola et al.   Cell Reports

Amyloid Clearance as a Treatment Target Against Alzheimer's Disease

(2018) Alexander Kurz et al.   JOURNAL OF ALZHEIMERS DISEASE

Abnormal Hyperphosphorylation of Tau: Sites, Regulation, and Molecular Mechanism of Neurofibrillary Degeneration

(2018) Jian-Zhi Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Differential Activation of mTOR Complex 1 Signaling in Human Brain with Mild to Severe Alzheimer's Disease

(2018) Yong-Xin Sun et al.   JOURNAL OF ALZHEIMERS DISEASE

Structural brain changes in medically refractory focal epilepsy resemble premature brain aging

(2017) Heath R. Pardoe et al.   EPILEPSY RESEARCH

Epileptic activity in Alzheimer's disease: causes and clinical relevance

(2017) Keith A Vossel et al.   LANCET NEUROLOGY

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

(2017) Alice D Lam et al.   NATURE MEDICINE

Antiepileptic action of c-Jun N-terminal kinase (JNK) inhibition in an animal model of temporal lobe epilepsy

(2017) Tina Y. Tai et al.   NEUROSCIENCE

Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery

(2017) Ingmar Blumcke et al.   NEW ENGLAND JOURNAL OF MEDICINE

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

(2017) Fatou Amar et al.   Science Signaling

Prevalence and Incidence of Drug-Resistant Mesial Temporal Lobe Epilepsy in the United States

(2017) Ali A. Asadi-Pooya et al.   World Neurosurgery

Association Between Childhood-Onset Epilepsy and Amyloid Burden 5 Decades Later

(2017) Juho Joutsa et al.   JAMA Neurology

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

(2017) Fatou Amar et al.   Science Signaling

Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2

(2017) Riqiang Yan   Frontiers in Molecular Neuroscience

Dysregulation of Tau Phosphorylation in Mouse Brain during Excitotoxic Damage

(2017) Zhihou Liang et al.   JOURNAL OF ALZHEIMERS DISEASE

Incidence and impact of subclinical epileptiform activity in Alzheimer's disease

(2016) Keith A. Vossel et al.   ANNALS OF NEUROLOGY

Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau

(2016) Shi-jie Liu et al.   BRAIN

Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections

(2016) Xin You Tai et al.   BRAIN

Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy

(2016) Vikram Puvenna et al.   BRAIN RESEARCH

Caspase-2 cleavage of tau reversibly impairs memory

(2016) Xiaohui Zhao et al.   NATURE MEDICINE

Interictal epileptiform discharges induce hippocampal–cortical coupling in temporal lobe epilepsy

(2016) Jennifer N Gelinas et al.   NATURE MEDICINE

Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model

(2016) Kathleen M. Schoch et al.   NEURON

Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss

(2016) J. Di et al.   Scientific Reports

Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61Substrates Involved in Hippocampal Synaptic Plasticity

(2016) Sung-Soo Jang et al.   NEURAL PLASTICITY

APP Causes Hyperexcitability in Fragile X Mice

(2016) Cara J. Westmark et al.   Frontiers in Molecular Neuroscience

mTor mediates tau localization and secretion: Implication for Alzheimer's disease

(2015) Zhi Tang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Effect of epileptic seizures on the cerebrospinal fluid – A systematic retrospective analysis

(2015) Hayrettin Tumani et al.   EPILEPSY RESEARCH

Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2015) A. Caccamo et al.   JOURNAL OF NEUROSCIENCE

Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline

(2015) Sarah Gourmaud et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome

(2015) Emanuela Pasciuto et al.   NEURON

Expression of neurodegenerative disease-related proteins and caspase-3 in glioneuronal tumours

(2015) A. S. Prabowo et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Seizures in Alzheimer’s disease

(2015) H.A. Born   NEUROSCIENCE

Tau reduction prevents disease in a mouse model of Dravet syndrome

(2014) Ania L. Gheyara et al.   ANNALS OF NEUROLOGY

Role of Endoplasmic Reticulum Stress via the PERK Signaling Pathway in Brain Injury from Status Epilepticus

(2014) Jing Chen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease

(2014) H. A. Born et al.   JOURNAL OF NEUROSCIENCE

Expression of β-amyloid precursor protein in refractory epilepsy

(2014) XIUTIAN SIMA et al.   Molecular Medicine Reports

PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease

(2014) Latha Devi et al.   NEUROBIOLOGY OF AGING

Seizure resistance without parkinsonism in aged mice after tau reduction

(2014) Zhiyong Li et al.   NEUROBIOLOGY OF AGING

Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid

(2013) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Isoform transition from four-repeat to three-repeat tau underlies dendrosomatic and regional progression of neurofibrillary pathology

(2013) Makoto Hara et al.   ACTA NEUROPATHOLOGICA

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

(2013) Antonella Caccamo et al.   AGING CELL

Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus

(2013) Jesús F. Torres-Peraza et al.   BRAIN

Cell injury and Premature Neurodegeneration in Focal Malformations of Cortical Development

(2013) Anand Iyer et al.   BRAIN PATHOLOGY

AMPA Receptor antagonist NBQX attenuates later-life epileptic seizures and autistic-like social deficits following neonatal seizures

(2013) Jocelyn J. Lippman-Bell et al.   EPILEPSIA

International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods

(2013) Ingmar Blümcke et al.   EPILEPSIA

Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms

(2013) Jeannie Chin et al.   EPILEPSY & BEHAVIOR

Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and Drosophila Genetic Models of Epilepsy

(2013) J. K. Holth et al.   JOURNAL OF NEUROSCIENCE

Antisense Reduction of Tau in Adult Mice Protects against Seizures

(2013) S. L. DeVos et al.   JOURNAL OF NEUROSCIENCE

Hippocampal interictal epileptiform activity disrupts cognition in humans

(2013) J. K. Kleen et al.   NEUROLOGY

Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Brain structure and aging in chronic temporal lobe epilepsy

(2012) Kevin Dabbs et al.   EPILEPSIA

Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

(2012) Erwin A. van Vliet et al.   EPILEPSIA

Transcriptional and post-transcriptional regulation of β-secretase

(2012) Elena Tamagno et al.   IUBMB LIFE

Should cognition be screened in new-onset epilepsies? A study in 247 untreated patients

(2012) Juri-Alexander Witt et al.   JOURNAL OF NEUROLOGY

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

(2012) Katherine L Youmans et al.   Molecular Neurodegeneration

What’s hAPPening at synapses? The role of amyloid β-protein precursor and β-amyloid in neurological disorders

(2012) C J Westmark   MOLECULAR PSYCHIATRY

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

(2012) Julie A. Moreno et al.   NATURE

Activation of the Unfolded Protein Response Is an Early Event in Alzheimer’s and Parkinson’s Disease

(2012) Jeroen J.M. Hoozemans et al.   Neurodegenerative Diseases

Age at onset of epilepsy, pharmacoresistance, and cognitive outcomes: A prospective cohort study

(2012) A. T. Berg et al.   NEUROLOGY

The Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway

(2012) Delia M. Talos et al.   PLoS One

Chronic Temporal Lobe Epilepsy Is Associated with Enhanced Alzheimer-Like Neuropathology in 3×Tg-AD Mice

(2012) Xiao-Xin Yan et al.   PLoS One

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling

(2012) Christian Appenzeller-Herzog et al.   TRENDS IN CELL BIOLOGY

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study

(2011) Maria Thom et al.   BRAIN

Epilepsy as a spectrum disorder: Implications from novel clinical and basic neuroscience

(2011) Frances E. Jensen   EPILEPSIA

A perfect storm: Converging paths of epilepsy and Alzheimer’s dementia intersect in the hippocampal formation

(2011) Jeffrey Noebels   EPILEPSIA

Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels

(2011) Sofya Ziyatdinova et al.   EPILEPSY RESEARCH

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models

(2011) Nigel C. Jones et al.   NEUROBIOLOGY OF DISEASE

Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex

(2011) J. Goto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The c-Jun N-terminal kinase inhibitor SP600125 is neuroprotective in amygdala kindled rats

(2010) Xu Chen et al.   BRAIN RESEARCH

Involvement of IRE1α signaling in the hippocampus in patients with mesial temporal lobe epilepsy

(2010) Gonglu Liu et al.   BRAIN RESEARCH BULLETIN

The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1

(2010) Ingmar Blümcke et al.   EPILEPSIA

c-Jun N-terminal kinase signaling pathway in excitotoxic cell death following kainic acid-induced status epilepticus

(2010) Giada Spigolon et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

(2010) Xiaoxing Huang et al.   NEUROBIOLOGY OF DISEASE

Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

(2010) K.J. Lee et al.   NEUROSCIENCE

Epilepsy and Cognitive Impairments in Alzheimer Disease

(2009) Jorge J. Palop   ARCHIVES OF NEUROLOGY

Patients with epilepsy: Cognitively compromised before the start of antiepileptic drug treatment?

(2009) Joanne Taylor et al.   EPILEPSIA

The Effects of Amyloid Precursor Protein on Postsynaptic Composition and Activity

(2009) Hyang-Sook Hoe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy

(2009) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

Tuberous Sclerosis Complex Activity Is Required to Control Neuronal Stress Responses in an mTOR-Dependent Manner

(2009) A. Di Nardo et al.   JOURNAL OF NEUROSCIENCE

In Vivo Turnover of Tau and APP Metabolites in the Brains of Wild-Type and Tg2576 Mice: Greater Stability of sAPP in the β-Amyloid Depositing Mice

(2009) Jose Morales-Corraliza et al.   PLoS One

Early Alterations of AMPA Receptors Mediate Synaptic Potentiation Induced by Neonatal Seizures

(2008) S. N. Rakhade et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON

Phosphorylation of thr668 in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3)

(2003) Claire L. Standen et al.   JOURNAL OF NEUROCHEMISTRY