Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease

Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation

(2020) Prerana Shrestha et al.   NATURE NEUROSCIENCE

Fine tuning of the unfolded protein response by ISRIB improves neuronal survival in a model of amyotrophic lateral sclerosis

(2020) Ricardo Bugallo et al.   Cell Death & Disease

Small molecule cognitive enhancer reverses age-related memory decline in mice

(2020) Karen Krukowski et al.   eLife

eIF2B activator prevents neurological defects caused by a chronic integrated stress response

(2019) Yao Liang Wong et al.   eLife

Small molecule ISRIB suppresses the integrated stress response within a defined window of activation

(2019) Huib H. Rabouw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions

(2019) Marion Tible et al.   AGING CELL

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response

(2019) Lillian R. Kenner et al.   SCIENCE

Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome

(2019) Ping Jun Zhu et al.   SCIENCE

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule

(2018) Jordan C. Tsai et al.   SCIENCE

ER Proteostasis Control of Neuronal Physiology and Synaptic Function

(2018) Gabriela Martínez et al.   TRENDS IN NEUROSCIENCES

C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation

(2018) Weiwei Cheng et al.   Nature Communications

Regulation of translation initiation factor eIF2B at the hub of the integrated stress response

(2018) Graham D. Pavitt   Wiley Interdisciplinary Reviews-RNA

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

(2018) Mychael V. Lourenco et al.   NATURE MEDICINE

Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α

(2017) Z D Kabir et al.   MOLECULAR PSYCHIATRY

Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury

(2017) Austin Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The UPR and synaptic dysfunction in neurodegeneration

(2016) Oliver J. Freeman et al.   BRAIN RESEARCH

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease

(2016) Wenzhong Yang et al.   NEUROBIOLOGY OF AGING

BONLAC: A combinatorial proteomic technique to measure stimulus-induced translational profiles in brain slices

(2016) Heather Bowling et al.   NEUROPHARMACOLOGY

eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons

(2016) Andon N Placzek et al.   eLife

PKR Inhibition Rescues Memory Deficit and ATF4 Overexpression in ApoE  4 Human Replacement Mice

(2015) Y. Segev et al.   JOURNAL OF NEUROSCIENCE

Mutations in a translation initiation factor identify the target of a memory-enhancing compound

(2015) Y. Sekine et al.   SCIENCE

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

(2015) M Halliday et al.   Cell Death & Disease

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

(2015) Carmela Sidrauski et al.   eLife

Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions

(2014) Jimena Baleriola et al.   CELL

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α

(2014) Gonzalo Viana Di Prisco et al.   NATURE NEUROSCIENCE

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A  Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers

(2013) C. P. Figueiredo et al.   JOURNAL OF NEUROSCIENCE

Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation

(2013) J. F. Abisambra et al.   JOURNAL OF NEUROSCIENCE

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

(2013) Tao Ma et al.   NATURE NEUROSCIENCE

Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory

(2013) Mimi A. Trinh et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

Amyloid-β Oligomers Induce Differential Gene Expression in Adult Human Brain Slices

(2012) Adriano Sebollela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice

(2012) J H Ledo et al.   MOLECULAR PSYCHIATRY

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

(2012) Julie A. Moreno et al.   NATURE

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress

(2011) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

Both Transcriptional Regulation and Translational Control of ATF4 Are Central to the Integrated Stress Response

(2010) Souvik Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

(2008) Fabrizio Trinchese et al.   JOURNAL OF CLINICAL INVESTIGATION

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols