Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model

Regulation of Age-Related Protein Toxicity

(2021) Anita Pras et al.   Frontiers in Cell and Developmental Biology

Hedgehog Signaling Modulates Glial Proteostasis and Lifespan

(2020) Andrew Rallis et al.   Cell Reports

Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer’s disease model mice

(2019) Brenna C. Beckelman et al.   JOURNAL OF CLINICAL INVESTIGATION

Decreased synthesis of ribosomal proteins in tauopathy revealed by non‐canonical amino acid labelling

(2019) Harrison Tudor Evans et al.   EMBO JOURNAL

TMT labeling for the masses: A robust and cost-efficient, in-solution labeling approach

(2019) Jana Zecha et al.   MOLECULAR & CELLULAR PROTEOMICS

Local translation in neurons: visualization and function

(2019) Christine E. Holt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Altered steady state and activity-dependent de novo protein expression in fragile X syndrome

(2019) Heather Bowling et al.   Nature Communications

Single-cell transcriptomic profiling of the aging mouse brain

(2019) Methodios Ximerakis et al.   NATURE NEUROSCIENCE

Studies on APP metabolism related to age-associated mitochondrial dysfunction in APP/PS1 transgenic mice

(2019) Lizhi Chen et al.   Aging-US

On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons

(2019) Toshiaki Shigeoka et al.   Cell Reports

Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies

(2018) Ralph N. Martins et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease

(2018) Russell H. Swerdlow   JOURNAL OF ALZHEIMERS DISEASE

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Amyloid precursor protein and endosomal–lysosomal dysfunction in Alzheimer’s disease: inseparable partners in a multifactorial disease

(2017) Ralph A. Nixon   FASEB JOURNAL

Machine learning techniques to discover genes with potential prognosis role in Alzheimer’s disease using different biological sources

(2017) María Martínez-Ballesteros et al.   Information Fusion

Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide

(2017) Zhen Shi et al.   MOLECULAR CELL

Neuropathologic Alterations in Mild Cognitive Impairment: A Review

(2017) William R. Markesbery   JOURNAL OF ALZHEIMERS DISEASE

BONLAC: A combinatorial proteomic technique to measure stimulus-induced translational profiles in brain slices

(2016) Heather Bowling et al.   NEUROPHARMACOLOGY

CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase

(2015) Amir Kumar Singh et al.   AGING CELL

Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome

(2015) Karina Hernández-Ortega et al.   BRAIN PATHOLOGY

Mitochondrial Superoxide Contributes to Hippocampal Synaptic Dysfunction and Memory Deficits in Angelman Syndrome Model Mice

(2015) E. Santini et al.   JOURNAL OF NEUROSCIENCE

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Differential Stoichiometry among Core Ribosomal Proteins

(2015) Nikolai Slavov et al.   Cell Reports

Translational Control in Synaptic Plasticity and Cognitive Dysfunction

(2014) Shelly A. Buffington et al.   Annual Review of Neuroscience

In-Depth Quantitative Proteomic Analysis of de Novo Protein Synthesis Induced by Brain-Derived Neurotrophic Factor

(2014) Guoan Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Tracking the earliest pathologic changes in Alzheimer disease

(2014) S. M. Landau et al.   NEUROLOGY

Exercise-Induced Neuroprotection of Hippocampus in APP/PS1 Transgenic Mice via Upregulation of Mitochondrial 8-Oxoguanine DNA Glycosylase

(2014) Hai Bo et al.   Oxidative Medicine and Cellular Longevity

Antipsychotics Activate mTORC1-Dependent Translation to Enhance Neuronal Morphological Complexity

(2014) H. Bowling et al.   Science Signaling

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Synaptic Changes in the Dentate Gyrus of APP/PS1 Transgenic Mice Revealed by Electron Microscopy

(2013) Lidia Alonso-Nanclares et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

(2013) Tao Ma et al.   NATURE NEUROSCIENCE

In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation

(2013) M. T. Butko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Reduction of the α1 Subunit of Na/K-ATPase Corrects Multiple Hippocampal Phenotypes in Angelman Syndrome

(2013) Hanoch Kaphzan et al.   Cell Reports

Selective enrichment of newly synthesized proteins for quantitative secretome analysis

(2012) Katrin Eichelbaum et al.   NATURE BIOTECHNOLOGY

Dopaminergic modulation of the hippocampal neuropil proteome identified by bioorthogonal noncanonical amino acid tagging (BONCAT)

(2012) Jennifer J. L. Hodas et al.   PROTEOMICS

Synaptic Mitochondrial Pathology in Alzheimer's Disease

(2011) Heng Du et al.   ANTIOXIDANTS & REDOX SIGNALING

Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex

(2011) Itzamarie Chévere-Torres et al.   NEUROBIOLOGY OF DISEASE

Eukaryotic Cells Producing Ribosomes Deficient in Rpl1 Are Hypersensitive to Defects in the Ubiquitin-Proteasome System

(2011) Kerri B. McIntosh et al.   PLoS One

Inhibitors of Catalase-Amyloid Interactions Protect Cells from β-Amyloid-Induced Oxidative Stress and Toxicity

(2010) Lila K. Habib et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of mTOR Signaling in Fragile X Syndrome

(2010) A. Sharma et al.   JOURNAL OF NEUROSCIENCE

Synaptic Plasticity in the Hippocampus of a APP/PS1 Mouse Model of Alzheimer's Disease Is Impaired in Old but Not Young Mice

(2010) Simon Gengler et al.   PLoS One

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Making synaptic plasticity and memory last: mechanisms of translational regulation

(2009) J. D. Richter et al.   GENES & DEVELOPMENT

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

Independent component analysis of Alzheimer's DNA microarray gene expression data

(2009) Wei Kong et al.   Molecular Neurodegeneration

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Translational Control of Long-Lasting Synaptic Plasticity and Memory

(2009) Mauro Costa-Mattioli et al.   NEURON

Reversal of long-term dendritic spine alterations in Alzheimer disease models

(2009) D. L. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice

(2008) R. Minkeviciene et al.   JOURNAL OF NEUROCHEMISTRY

Stable Isotopic Labeling by Amino Acids in Cultured Primary Neurons

(2008) Daniel S. Spellman et al.   MOLECULAR & CELLULAR PROTEOMICS

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice

(2008) S. Hauptmann et al.   NEUROBIOLOGY OF AGING

Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1ΔE9-deleted transgenic mice model of β-amyloidosis

(2008) Arturas Volianskis et al.   NEUROBIOLOGY OF AGING

Aged wild-type and APP, PS1, and APP+PS1 mice present similar deficits in associative learning and synaptic plasticity independent of amyloid load

(2008) A. Gruart et al.   NEUROBIOLOGY OF DISEASE