Human microphysiological systems for drug development

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

(2021) Longlong Si et al.   Nature Biomedical Engineering

On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology

(2020) David B. Chou et al.   Nature Biomedical Engineering

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

(2020) Anna Herland et al.   Nature Biomedical Engineering

Metal‐Specific Biomaterial Accumulation in Human Peri‐Implant Bone and Bone Marrow

(2020) Janosch Schoon et al.   Advanced Science

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

(2019) Sasan Jalili-Firoozinezhad et al.   Nature Biomedical Engineering

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics

(2019) Christopher W. McAleer et al.   Science Translational Medicine

Reproducing human and cross-species drug toxicities using a Liver-Chip

(2019) Kyung-Jin Jang et al.   Science Translational Medicine

Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems

(2018) Riccardo Barrile et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation

(2018) Michelle B. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

(2018) Ben M Maoz et al.   NATURE BIOTECHNOLOGY

Simultaneous evaluation of anti-EGFR-induced tumour and adverse skin effects in a microfluidic human 3D co-culture model

(2018) Juliane Hübner et al.   Scientific Reports

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE