Machine learning enables discovery of Gentianine targeting TLR4/NF-κB pathway to repair ischemic stroke injury

Trelagliptin Mitigates Macrophage Infiltration by Preventing the Breakdown of the Blood–Brain Barrier in the Brain of Middle Cerebral Artery Occlusion Mice

(2021) Li’e Zang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Network pharmacology study on the mechanism of the herb pair of prepared Rehmannia root-Chinese arborvitae kernel for anxiety disorders

(2021) Pu-Lin Liu et al.   Annals of Palliative Medicine

Artificial intelligence and network pharmacology based investigation of pharmacological mechanism and substance basis of Xiaokewan in treating diabetes

(2020) Chunyan Zhu et al.   PHARMACOLOGICAL RESEARCH

Eupafolin alleviates cerebral ischemia/reperfusion injury in rats via blocking the TLR4/NF‑κB signaling pathway

(2020) Xingwang Chen et al.   Molecular Medicine Reports

Ulinastatin alleviates cerebral ischemia-reperfusion injury in rats by activating the Nrf-2/HO-1 signaling pathway

(2020) Lei Cui et al.   Annals of Translational Medicine

Database limitations for studying the human gut microbiome

(2020) Camila K Dias et al.   PeerJ Computer Science

Nervilifordin F alleviates intestinal ischemia/reperfusion-induced acute lung injury via inhibiting inflammasome and mTOR pathway

(2020) Yanjun Tan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders

(2019) Gunnar R. Leitner et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

miR-98 reduces endothelial dysfunction by protecting blood–brain barrier (BBB) and improves neurological outcomes in mouse ischemia/reperfusion stroke model

(2019) David L Bernstein et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ischaemic stroke

(2019) Bruce C. V. Campbell et al.   Nature Reviews Disease Primers

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation

(2018) Zengli Zhang et al.   Journal of Neuroinflammation

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells

(2018) Chuanhong Wu et al.   Scientific Reports

The regulatory role of Toll-like receptors after ischemic stroke: neurosteroids as TLR modulators with the focus on TLR2/4

(2018) Saeedeh Tajalli-Nezhad et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway

(2018) Fu-yi Liu et al.   Journal of Neuroinflammation

SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping

(2018) Yang Wu et al.   NUCLEIC ACIDS RESEARCH

Protective Effect of Gentianine, a compound from Du Huo Ji Sheng Tang, against Freund’s Complete Adjuvant-Induced Arthritis in Rats

(2017) Chen Wenjin et al.   INFLAMMATION

Wnt/β-catenin coupled with HIF-1α/VEGF signaling pathways involved in galangin neurovascular unit protection from focal cerebral ischemia

(2015) Chuanhong Wu et al.   Scientific Reports

An Effective Solution to Discover Synergistic Drugs for Anti-Cerebral Ischemia from Traditional Chinese Medicinal Formulae

(2013) Shaojing Li et al.   PLoS One

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

(2012) Gaby Enzmann et al.   ACTA NEUROPATHOLOGICA

By Improving Regional Cortical Blood Flow, Attenuating Mitochondrial Dysfunction and Sequential Apoptosis Galangin Acts as a Potential Neuroprotective Agent after Acute Ischemic Stroke

(2012) Shaojing Li et al.   MOLECULES

Anti-diabetic Activity of Swertiamarin is due to an Active Metabolite, Gentianine, that Upregulates PPAR-γ Gene Expression in 3T3-L1 cells

(2012) Hitesh Vaidya et al.   PHYTOTHERAPY RESEARCH