Article
Plant Sciences
Bin Li, Baoke Zhang, Zhenyu Li, Shasha Li, Jun Li, Aiwu Wang, Jinling Hou, Jiping Xu, Rui Zhang
Summary: The study aimed to investigate the potential of ginkgolide C (GC), an active ingredient in Ginkgo biloba leaves, to attenuate cerebral ischemia/reperfusion injury (CI/RI) and its anti-inflammatory effect through suppression of the CD40/NF-kappa B pathway. The results showed that GC reduced neurological scores, cerebral infarct rate, and brain edema, while improving microvessel ultrastructure and blood-brain barrier integrity. GC also inhibited the release of inflammatory mediators and enhanced cell viability. These effects were mediated through the suppression of the CD40/NF-kappa B pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Xiu-fen Zheng, Xiang-jian Zhang, Li-peng Dong, Jing-ru Zhao, Cong Zhang, Rong Chen
Summary: Sal B protects brain tissues from cerebral ischemia-reperfusion injury by activating its anti-inflammatory properties.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Sen Liang, Zhaoyao Chen, Hui Li, Zhilan Cang, Kailin Yin, Minghua Wu, Shouzhen Luo
Summary: The study demonstrated that umbelliferone possesses neuroprotective effects against ischemia/reperfusion injury by inhibiting the inflammatory pathway, leading to reduced neurological deficits and brain damage in rats.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Review
Biochemistry & Molecular Biology
Patricia G. G. Valles, Andrea Fernanda Gil Lorenzo, Rodrigo D. D. Garcia, Valeria Cacciamani, Maria Eugenia Benardon, Valeria Victoria Costantino
Summary: Acute kidney injury (AKI) is a common and devastating condition with no effective pharmacological treatment. Toll-like receptor 4 (TLR4) and its ligands play a crucial role in the pathogenesis of AKI by mediating inflammatory responses. Excessive activation of TLR4 can lead to chronic inflammation. This review discusses the role of TLR4 in ischemic/reperfusion-induced AKI and sepsis-associated AKI, as well as its potential signaling patterns in kidney injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Chaojun Hu, Shan Zhang, Qian Chen, Rong Wang
Summary: Ovatodiolide (OVA) can alleviate neurological deficits and brain tissue damage caused by ischemia-reperfusion (I/R) by inhibiting neuronal apoptosis and microglial inflammation.
BRAIN RESEARCH BULLETIN
(2022)
Review
Immunology
Niloofar Deravi, Mohadeseh Poudineh, Marzieh Pirzadeh, Hanie Yavarpour-Bali, Hoda Mehrabi, Gisou Erabi, Amene Saghazadeh, Nima Rezaei
Summary: Endothelial cells play a critical role in innate immune and inflammatory responses, and Toll-like receptors (TLRs) are key in activating innate mechanisms in ECs. Endothelial dysfunction may lead to tissue damage in various diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lu-Yuan Peng, Hai-Tao Shi, Yue-Rong Tan, Si-Yang Shen, Peng-Fei Yi, Hai-Qing Shen, Ben-Dong Fu
Summary: The study found that baicalin protected against APEC infection by modulating gut microbiota, increasing short chain fatty acid (SCFA) production, especially acetate. Acetate may circulate to the lungs to activate FFAR2 to defend against APEC infection.
Article
Chemistry, Medicinal
Seokwon Shin, Jayeon Park, Ye Eun Lee, Hanbin Ko, Hyung-Sun Youn
Summary: Toll-like receptors (TLRs) play a crucial role in immune responses by activating signaling pathways that induce inflammation. Research has shown that isobavachalcone (IBC) can inhibit the activation of TLR signaling pathways, opening up new therapeutic options for inflammatory diseases involving TLRs.
ARCHIV DER PHARMAZIE
(2022)
Review
Biochemistry & Molecular Biology
Saahithh Redddi Patlola, Gary Donohoe, Declan P. McKernan
Summary: Toll-like receptors (TLRs) are pattern recognition receptors that protect the brain from self and foreign antigens/pathogens and can elicit a harmful or beneficial immune response. TLR activation has been associated with neurodegenerative diseases and cytokine imbalance in schizophrenia. This review explores the current literature on TLRs, their potential role in schizophrenia pathogenesis, factors affecting TLR activity and their impact on cognitive performance in schizophrenia.
Article
Chemistry, Multidisciplinary
Min Bai, Na Cui, Yucheng Liao, Chao Guo, Liang Li, Ying Yin, Aidong Wen, Jingwen Wang, Weiliang Ye, Yi Ding
Summary: Cerebral ischemia-reperfusion injury (CI/RI) is the main cause of disability and death in stroke. Danshensu (DSS) has anti-inflammatory effects, but its low cellular permeability and bioavailability limit its effectiveness. In this study, a new DSS preparation was developed using liposomes modified with phosphatidylserine (PS) and transferrin (TF) to improve the treatment of ischemic stroke. This formulation can cross the blood-brain barrier and target inflammatory glial cells, reducing inflammation and improving brain injury.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Wenjun Yan, Dongqing Ren, Xiaoxue Feng, Jinwen Huang, Dabin Wang, Ting Li, Dong Zhang
Summary: The study found that pterostilbene exhibited neuroprotective effects against cerebral ischemia in rats through anti-inflammatory mechanisms, improving body weight and glucose levels, reducing organ damage, lowering oxidative stress levels and inflammatory responses.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Dabao Yao, Shuo Zhang, Zhengwei Hu, Haiyang Luo, Chengyuan Mao, Yu Fan, Mibo Tang, Fen Liu, Si Shen, Liyuan Fan, Mengjie Li, Jingjing Shi, Jiadi Li, Dongrui Ma, Yuming Xu, Changhe Shi
Summary: The study showed that overexpression of CHIP may exert neuroprotective effects by attenuating necroptosis and inflammation during CIR injury.
Article
Immunology
Beilei Chen, Pingping Cao, Xin Guo, Mengmei Yin, Xiaobo Li, Li Jiang, Jun Shao, Xin Chen, Chao Jiang, Luhang Tao, Lin Zhou, Hailong Yu
Summary: This study demonstrates the neuroprotective effects of CCR5 inhibitor MVC in cerebral ischemia/reperfusion injury, showing its potential as a drug for ischemic stroke treatment in future clinical trials. MVC has been widely used for HIV treatment and has shown its safety. Based on its anti-inflammatory and anti-apoptotic mechanisms, we speculate that MVC may be a potential drug for treating ischemic stroke.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Behavioral Sciences
Cailian Ruan, Hongtao Guo, Jiaqi Gao, Yiwei Wang, Zhiyong Liu, Jinyi Yan, Xiaoji Li, Haixia Lv
Summary: The study found that Met effectively attenuated neurological deficits and neuronal apoptosis in a cerebral ischemia-reperfusion model, showing neuroprotective effects by inhibiting the activation of the PI3K/Akt pathway.
BRAIN AND BEHAVIOR
(2021)
Review
Biochemistry & Molecular Biology
Sihang Yu, Jiaying Fu, Jian Wang, Yuanxin Zhao, Buhan Liu, Jiahang Wei, Xiaoyu Yan, Jing Su
Summary: Cerebral ischemia-reperfusion injury is associated with inflammation caused by free mitochondrial DNA, and the pro-inflammatory activation of macrophages exacerbates the damage. By controlling the metabolic state of macrophages and targeting the mtDNA-driven inflammatory response, the possibility of injury can be reduced.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)