Journal
PHYTOTHERAPY RESEARCH
Volume 27, Issue 4, Pages 624-627Publisher
WILEY
DOI: 10.1002/ptr.4763
Keywords
Diabetes; swertiamarin; gentianine; PPAR-; GLUT-4; adiponectin
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Funding
- NSERC
- Canadian Commonwealth Exchange Program, Asia-Pacific
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We have previously shown the anti-diabetic effects of swertiamarin; however, pharmacokinetic analysis showed that swertiamarin had a plasma half-life of 1.3 h. Gentianine is an active metabolite of swertiamarin that possesses a pharmacophoric moiety. The aim of this study was to explore the possibility whether the anti-diabetic effect of swertiamarin is due to gentianine. Swertiamarin treatment had no significant effect on adipogenesis, or the mRNA expression of PPAR- and GLUT-4; however, there was a significant increase in the mRNA expression of adiponectin. On the other hand, treatment with gentianine significantly increased adipogenesis, which was associated with a significant increase in the mRNA expression of PPAR-, GLUT-4 and adiponectin. These findings suggest, for the first time, that the anti-diabetic effect of swertiamarin is due to gentianine, an active metabolite of swertiamarin. Copyright (c) 2012 John Wiley & Sons, Ltd.
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