Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer

The combined effect of food additive titanium dioxide and lipopolysaccharide on mouse intestinal barrier function after chronic exposure of titanium dioxide-contained feedstuffs

(2021) Yongliang Zhang et al.   Particle and Fibre Toxicology

Functions of Dendritic Cells and Its Association with Intestinal Diseases

(2021) Ze-Jun Yang et al.   Cells

Safety assessment of titanium dioxide (E171) as a food additive

(2021) et al.   EFSA Journal

Dendritic Cell Subsets in Intestinal Immunity and Inflammation

(2020) Tian Sun et al.   JOURNAL OF IMMUNOLOGY

The long-term oral exposure to titanium dioxide impaired immune functions and triggered cytotoxic and genotoxic impacts in rats

(2020) Mohamed M. Hashem et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Impacts of foodborne inorganic nanoparticles on the gut microbiota-immune axis: potential consequences for host health

(2020) Bruno Lamas et al.   Particle and Fibre Toxicology

Oral toxicity of titanium dioxide P25 at repeated dose 28-day and 90-day in rats

(2020) Min Beom Heo et al.   Particle and Fibre Toxicology

Foodborne Titanium Dioxide Nanoparticles Induce Stronger Adverse Effects in Obese Mice than Non‐Obese Mice: Gut Microbiota Dysbiosis, Colonic Inflammation, and Proteome Alterations

(2020) Xiaoqiong Cao et al.   Small

Food-grade titanium dioxide (E171) induces anxiety, adenomas in colon and goblet cells hyperplasia in a regular diet model and microvesicular steatosis in a high fat diet model

(2020) Estefany I. Medina-Reyes et al.   FOOD AND CHEMICAL TOXICOLOGY

Toxicity of orally administered food‐grade titanium dioxide nanoparticles

(2020) Hyoung‐Yun Han et al.   JOURNAL OF APPLIED TOXICOLOGY

Telomere length and genotoxicity in the lung of rats following intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

(2019) Ditte Marie Jensen et al.   MUTAGENESIS

T lymphocytes in the intestinal mucosa: defense and tolerance

(2019) Hongdi Ma et al.   Cellular & Molecular Immunology

Role of Mucin in Behavior of Food-Grade TiO2 Nanoparticles under Simulated Oral Conditions

(2019) Hualu Zhou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Repeated administration of the food additive E171 to mice results in accumulation in intestine and liver and promotes an inflammatory status

(2019) Laura Talamini et al.   Nanotoxicology

Evaluation of immunologic and intestinal effects in rats administered an E 171-containing diet, a food grade titanium dioxide (TiO2)

(2019) Lance K. Blevins et al.   FOOD AND CHEMICAL TOXICOLOGY

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2019) Sudabeh Alatab et al.   Lancet Gastroenterology & Hepatology

Dissolution Behavior And Biodurability Of Ingested Engineered Nanomaterials In The Gastrointestinal Environment

(2018) Ikjot Singh Sohal et al.   ACS Nano

Gene expression profiling in colon of mice exposed to food additive titanium dioxide (E171)

(2018) Héloïse Proquin et al.   FOOD AND CHEMICAL TOXICOLOGY

Nano-TiO2 Drives Epithelial-Mesenchymal Transition in Intestinal Epithelial Cancer Cells

(2018) Magdiel Inggrid Setyawati et al.   Small

Transcriptomics analysis reveals new insights in E171-induced molecular alterations in a mouse model of colon cancer

(2018) Héloïse Proquin et al.   Scientific Reports

Toxicity of Food-Grade TiO2 to Commensal Intestinal and Transient Food-Borne Bacteria: New Insights Using Nano-SIMS and Synchrotron UV Fluorescence Imaging

(2018) Joanna M. Radziwill-Bienkowska et al.   Frontiers in Microbiology

Food-grade TiO2 is trapped by intestinal mucus in vitro but does not impair mucin O-glycosylation and short-chain fatty acid synthesis in vivo: implications for gut barrier protection

(2018) Pauline Talbot et al.   JOURNAL OF NANOBIOTECHNOLOGY

Oral administration of rutile and anatase TiO2 nanoparticles shifts mouse gut microbiota structure

(2018) Juan Li et al.   Nanoscale

Analysis of the Gut Microbiome of Rural and Urban Healthy Indians Living in Sea Level and High Altitude Areas

(2018) Bhabatosh Das et al.   Scientific Reports

TiO 2 -based photocatalytic disinfection of microbes in aqueous media: A review

(2017) P.Venkata Laxma Reddy et al.   ENVIRONMENTAL RESEARCH

Does intranasal instillation TiO2 cause pulmonary tumorigenesis in male mice?

(2017) Peter Møller et al.   ENVIRONMENTAL TOXICOLOGY

Impact of food grade and nano-TiO 2 particles on a human intestinal community

(2017) William Dudefoi et al.   FOOD AND CHEMICAL TOXICOLOGY

Gastric toxicity involving alterations of gastritis-related protein expression in mice following long-term exposure to nano TiO 2

(2017) Fashui Hong et al.   FOOD RESEARCH INTERNATIONAL

Absorption, Distribution and Excretion of Four Forms of Titanium Dioxide Pigment in the Rat

(2017) Thomas P. Farrell et al.   JOURNAL OF FOOD SCIENCE

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Continuous in vitro exposure of intestinal epithelial cells to E171 food additive causes oxidative stress, inducing oxidation of DNA bases but no endoplasmic reticulum stress

(2017) Marie Dorier et al.   Nanotoxicology

Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

(2017) Sarah Bettini et al.   Scientific Reports

Food-grade titanium dioxide exposure exacerbates tumor formation in colitis associated cancer model

(2016) Ismael M. Urrutia-Ortega et al.   FOOD AND CHEMICAL TOXICOLOGY

Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome

(2016) Pedro A Ruiz et al.   GUT

Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions

(2016) Héloïse Proquin et al.   MUTAGENESIS

Oral intake of added titanium dioxide and its nanofraction from food products, food supplements and toothpaste by the Dutch population

(2016) Cathy Rompelberg et al.   Nanotoxicology

Risk assessment of titanium dioxide nanoparticles via oral exposure, including toxicokinetic considerations

(2016) Minne B. Heringa et al.   Nanotoxicology

Nanomaterials for products and application in agriculture, feed and food

(2016) Ruud J.B. Peters et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Human Intestinal Barrier Function in Health and Disease

(2016) Julia König et al.   Clinical and Translational Gastroenterology

Acute and subchronic oral toxicity studies in rats with nanoscale and pigment grade titanium dioxide particles

(2015) D.B. Warheit et al.   FOOD AND CHEMICAL TOXICOLOGY

Exposome in IBD

(2015) Gerhard Rogler et al.   INFLAMMATORY BOWEL DISEASES

Pro-inflammatory responses of RAW264.7 macrophages when treated with ultralow concentrations of silver, titanium dioxide, and zinc oxide nanoparticles

(2015) Marcella Giovanni et al.   JOURNAL OF HAZARDOUS MATERIALS

Impact of anatase and rutile titanium dioxide nanoparticles on uptake carriers and efflux pumps in Caco-2 gut epithelial cells

(2015) M. Dorier et al.   Nanoscale

Pharmaceutical/food grade titanium dioxide particles are absorbed into the bloodstream of human volunteers

(2015) Laetitia C. Pele et al.   Particle and Fibre Toxicology

Human in vivo and in vitro studies on gastrointestinal absorption of titanium dioxide nanoparticles

(2015) Kate Jones et al.   TOXICOLOGY LETTERS

The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine

(2015) L Baron et al.   Cell Death & Disease

Food grade titanium dioxide disrupts intestinal brush border microvilli in vitro independent of sedimentation

(2014) James J. Faust et al.   CELL BIOLOGY AND TOXICOLOGY

Understanding TiO2 Photocatalysis: Mechanisms and Materials

(2014) Jenny Schneider et al.   CHEMICAL REVIEWS

Intestinal barrier dysfunction triggered by invasive bacteria

(2014) F Barreau et al.   CURRENT OPINION IN MICROBIOLOGY

Characterization of Food-Grade Titanium Dioxide: The Presence of Nanosized Particles

(2014) Yu Yang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Th2 Factors May Be Involved in TiO2 NP-Induced Hepatic Inflammation

(2014) Jie Hong et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Characterization of Titanium Dioxide Nanoparticles in Food Products: Analytical Methods To Define Nanoparticles

(2014) Ruud J. B. Peters et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Nano-sized titanium dioxide-induced splenic toxicity: A biological pathway explored using microarray technology

(2014) Lei Sheng et al.   JOURNAL OF HAZARDOUS MATERIALS

Potential impact of metal oxide nanoparticles on the immune system: The role of integrins, L-selectin and the chemokine receptor CXCR4

(2014) Tamara Lozano-Fernández et al.   Nanomedicine-Nanotechnology Biology and Medicine

Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia

(2014) Emilie Brun et al.   Particle and Fibre Toxicology

Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats

(2014) Liesbeth Geraets et al.   Particle and Fibre Toxicology

Listeria monocytogenes Behaviour in Presence of Non-UV-Irradiated Titanium Dioxide Nanoparticles

(2014) Maria Grazia Ammendolia et al.   PLoS One

Intestinal barrier in inflammatory bowel disease

(2014) Lena Antoni   WORLD JOURNAL OF GASTROENTEROLOGY

Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis

(2014) Rafael Tojo   WORLD JOURNAL OF GASTROENTEROLOGY

Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches

(2013) Anna Ermund et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Differential Induction of Antimicrobial REGIII by the Intestinal Microbiota and Bifidobacterium breve NCC2950

(2013) Jane M. M. Natividad et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Exogenous Pigment in Peyer Patches of Children Suspected of Having IBD

(2013) Thalia Z. Hummel et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration

(2013) Wan-Seob Cho et al.   Particle and Fibre Toxicology

Titanium dioxide nanoparticles: a review of current toxicological data

(2013) Hongbo Shi et al.   Particle and Fibre Toxicology

Diversity, function, and transcriptional regulation of gut innate lymphocytes

(2013) Lucille Rankin   Frontiers in Immunology

Barrier dysfunction and bacterial uptake in the follicle-associated epithelium of ileal Crohn's disease

(2012) Åsa V. Keita et al.   Annals of the New York Academy of Sciences

Defects in autophagy favour adherent-invasive Escherichia coli persistence within macrophages leading to increased pro-inflammatory response

(2012) Pierre Lapaquette et al.   CELLULAR MICROBIOLOGY

Titanium Dioxide Nanoparticles in Food and Personal Care Products

(2012) Alex Weir et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Characterization and Preliminary Toxicity Assay of Nano-Titanium Dioxide Additive in Sugar-Coated Chewing Gum

(2012) Xin-Xin Chen et al.   Small

Susceptibility of Young and Adult Rats to the Oral Toxicity of Titanium Dioxide Nanoparticles

(2012) Yun Wang et al.   Small

NLRP3 Inflammasome Activation Induced by Engineered Nanomaterials

(2012) Bingbing Sun et al.   Small

Distinct immunomodulatory effects of a panel of nanomaterials in human dermal fibroblasts

(2012) Amelia A. Romoser et al.   TOXICOLOGY LETTERS

Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro

(2012) Yang Xue et al.   TOXICOLOGY LETTERS

Titanium dioxide induced inflammation in the small intestine

(2012) Carolina Maciel Nogueira   WORLD JOURNAL OF GASTROENTEROLOGY

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

Mucin dynamics and enteric pathogens

(2011) Michael A. McGuckin et al.   NATURE REVIEWS MICROBIOLOGY

The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine

(2011) S. Vaishnava et al.   SCIENCE

The Use of Nanoparticles to Control Oral Biofilm Formation

(2010) R.P. Allaker   JOURNAL OF DENTAL RESEARCH

Pulmonary Inflammation After Intraperitoneal Administration of Ultrafine Titanium Dioxide (TiO2) At Rest or in Lungs Primed with Lipopolysaccharide

(2010) Changsuk Moon et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Activation of the inflammasome by amorphous silica and TiO2nanoparticles in murine dendritic cells

(2010) Meike Winter et al.   Nanotoxicology

The intestinal barrier and its regulation by neuroimmune factors

(2010) å. v. Keita et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Exposure to Titanium Dioxide Nanomaterials Provokes Inflammation of an in Vitro Human Immune Construct

(2009) Brian C. Schanen et al.   ACS Nano

Non-UV-Induced Radical Reactions at the Surface of TiO2Nanoparticles That May Trigger Toxic Responses

(2009) Ivana Fenoglio et al.   CHEMISTRY-A EUROPEAN JOURNAL

Inflammation and oncogenesis: a vicious connection

(2009) Sergei I Grivennikov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches

(2009) F. Barreau et al.   GUT

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer

(2009) Linda A. Feagins et al.   Nature Reviews Gastroenterology & Hepatology

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ulcerative proctitis: a review of pharmacotherapy and management

(2008) Peter Laszlo Lakatos et al.   EXPERT OPINION ON PHARMACOTHERAPY

Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles

(2008) HouLi Li et al.   JOURNAL OF CONTROLLED RELEASE

Antimicrobial nanomaterials for water disinfection and microbial control: Potential applications and implications

(2008) Qilin Li et al.   WATER RESEARCH