Journal
CELLS
Volume 10, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/cells10030583
Keywords
dendritic cell; immune tolerance; IBD; intestinal tumor; intestinal flora
Categories
Funding
- National Natural Science Foundation of China [81673671, 81274173]
- Special National Key Research and Development Plan [2016YFC1306305]
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Dendritic cells play a crucial role in the immune system, including presenting antigen information, regulating the gut microbiome, and potentially being involved in diseases due to abnormal changes.
Dendritic cells (DCs), including conventional DCs (cDCs) and plasmacytoid DCs (pDCs), serve as the sentinel cells of the immune system and are responsible for presenting antigen information. Moreover, the role of DCs derived from monocytes (moDCs) in the development of inflammation has been emphasized. Several studies have shown that the function of DCs can be influenced by gut microbes including gut bacteria and viruses. Abnormal changes/reactions in intestinal DCs are potentially associated with diseases such as inflammatory bowel disease (IBD) and intestinal tumors, allowing DCs to be a new target for the treatment of these diseases. In this review, we summarized the physiological functions of DCs in the intestinal micro-environment, their regulatory relationship with intestinal microorganisms and their regulatory mechanism in intestinal diseases.
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