Redox Homeostasis and Prospects for Therapeutic Targeting in Neurodegenerative Disorders

Antioxidant Therapeutics in Parkinson’s Disease: Current Challenges and Opportunities

(2021) Ana Patricia Duarte-Jurado et al.   Antioxidants

The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction

(2021) Hilary Y. Liu et al.   Biomedicines

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

(2020) Nur Shafika Mohd Sairazi et al.   Evidence-based Complementary and Alternative Medicine

Another step forward in blood-based diagnostics for Alzheimer’s disease

(2020) Randall J. Bateman et al.   NATURE MEDICINE

Well Water and Parkinson’s Disease in Medicare Beneficiaries: A Nationwide Case-Control Study

(2020) Maya R. Silver et al.   Journal of Parkinsons Disease

Neuronal mitochondria-targeted delivery of curcumin by biomimetic engineered nanosystems in Alzheimer's disease mice

(2020) Chunhong Gao et al.   Acta Biomaterialia

Neuronal mitochondria-targeted micelles relieving oxidative stress for delayed progression of Alzheimer's disease

(2020) Peng Yang et al.   BIOMATERIALS

Amyloidogenic processing of Alzheimer’s disease β-amyloid precursor protein induces cellular iron retention

(2020) Andrew Tsatsanis et al.   MOLECULAR PSYCHIATRY

Protein transmission in neurodegenerative disease

(2020) Chao Peng et al.   Nature Reviews Neurology

Promising Polyphenols in Parkinson’s Disease Therapeutics

(2020) Ashish Singh et al.   NEUROCHEMICAL RESEARCH

Role of tau protein in Alzheimer's disease: The prime pathological player

(2020) Shibi Muralidar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson’s disease rat model

(2020) Hyung Woo Park et al.   Scientific Reports

Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

(2020) Ying-Wooi Wan et al.   Cell Reports

Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults

(2020) Shama Karanth et al.   JAMA Neurology

Reclassifying neurodegenerative diseases

(2020) Pablo Villoslada et al.   Nature Biomedical Engineering

The Role of Oxidative Stress in Parkinson’s Disease

(2020) Kuo-Hsuan Chang et al.   Antioxidants

Iron and inflammation: in vivo and post-mortem studies in Parkinson’s disease

(2020) Antonio Martin-Bastida et al.   JOURNAL OF NEURAL TRANSMISSION

Pathogenesis of Alzheimer’s disease: Multiple interacting causes against which amyloid precursor protein protects

(2020) A.F. Shah et al.   MEDICAL HYPOTHESES

Enhanced accumulation of reduced glutathione by Scopoletin improves survivability of dopaminergic neurons in Parkinson’s model

(2020) Priyadarshika Pradhan et al.   Cell Death & Disease

Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase

(2020) Marte I. Flydal et al.   BIOCHIMIE

Overexpression of Mitochondrial Ligases Reverses Rotenone-Induced Effects in a Drosophila Model of Parkinson’s Disease

(2019) Bartosz Doktór et al.   Frontiers in Neuroscience

Novel Approaches for the Treatment of Alzheimer’s and Parkinson’s Disease

(2019) Michiel Van Bulck et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biological effect of protein modifications by lipid peroxidation products

(2019) Agnieszka Gęgotek et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Parkinson's Disease and Parkinsonism

(2019) Michael T Hayes   AMERICAN JOURNAL OF MEDICINE

Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases

(2019) Fabrice Collin   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

(2019) Anju Singh et al.   MOLECULES

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

(2019) Connie Marras et al.   MOVEMENT DISORDERS

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

(2019) Benjamin G. Trist et al.   AGING CELL

Design, synthesis, and evaluation of novel N-(4-phenoxybenzyl)aniline derivatives targeting acetylcholinesterase, β-amyloid aggregation and oxidative stress to treat Alzheimer’s disease

(2019) Pavan Srivastava et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson's disease and in the hMPO-α-synuclein-A53T mouse model, correlating with increased nitration and aggregation of α-synuclein and exacerbation of motor impairment

(2019) Richard A. Maki et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of zinc, copper, manganese and iron in neurodegenerative diseases

(2019) Leda Mezzaroba et al.   NEUROTOXICOLOGY

ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells

(2019) Anastasiya V. Snezhkina et al.   Oxidative Medicine and Cellular Longevity

Current Progress of Mitochondrial Quality Control Pathways Underlying the Pathogenesis of Parkinson’s Disease

(2019) Xue Jiang et al.   Oxidative Medicine and Cellular Longevity

The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease

(2019) Shirley Yin-Yu Pang et al.   Translational Neurodegeneration

Plant Polyphenols as Neuroprotective Agents in Parkinson’s Disease Targeting Oxidative Stress

(2019) Suet Lee Hor et al.   CURRENT DRUG TARGETS

Natural Products in Neurodegenerative Diseases: A Great Promise but an Ethical Challenge

(2019) Marco Di Paolo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

5-S-cysteinyl-dopamine, a neurotoxic endogenous metabolite of dopamine: Implications for Parkinson's disease

(2019) Isidro Badillo-Ramírez et al.   NEUROCHEMISTRY INTERNATIONAL

Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer’s Disease

(2019) Federica Cioffi et al.   JOURNAL OF ALZHEIMERS DISEASE

Nrf2: Molecular and epigenetic regulation during aging

(2018) A. Silva-Palacios et al.   AGEING RESEARCH REVIEWS

Novel 8-hydroxyquinoline derivatives targeting β -amyloid aggregation, metal chelation and oxidative stress against Alzheimer’s disease

(2018) Xuelian Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ROS as Regulators of Mitochondrial Dynamics in Neurons

(2018) Carolina Cid-Castro et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Underlying Role of Oxidative Stress in Neurodegeneration: A Mechanistic Review

(2018) Habib Yaribeygi et al.   CNS & Neurological Disorders-Drug Targets

Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives

(2018) Jin-Sung Park et al.   Current Neurology and Neuroscience Reports

Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

(2018) Nadee Nissanka et al.   FEBS LETTERS

A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor

(2018) Shengquan Hu et al.   Frontiers in Pharmacology

Phosphorylation of different tau sites during progression of Alzheimer’s disease

(2018) Joerg Neddens et al.   Acta Neuropathologica Communications

Redox Proteomics Analysis of Brains from Subjects with Amnestic Mild Cognitive Impairment Compared to Brains from Subjects with Preclinical Alzheimer's Disease: Insights into Memory Loss in MCI

(2018) Christopher D. Aluise et al.   JOURNAL OF ALZHEIMERS DISEASE

Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs

(2018) Delphine Charvin et al.   NATURE REVIEWS DRUG DISCOVERY

Understanding multifactorial architecture of Parkinson’s disease: pathophysiology to management

(2018) Ramandeep Kaur et al.   NEUROLOGICAL SCIENCES

Dopamine, oxidative stress and protein-quinone modifications in Parkinson's and other neurodegenerative diseases

(2018) Enrico Monzani et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials

(2018) Franziska Pohl et al.   MOLECULES

Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability

(2018) Alejandra D. Alonso et al.   Frontiers in Cellular Neuroscience

Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease

(2018) E. Sandra Chocron et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Zinc regulates Nox1 expression through a NF-κB and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells

(2017) G. Salazar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Repeated-Dose Oral N-Acetylcysteine in Parkinson's Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress

(2017) Lisa D. Coles et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease

(2017) S Hunter et al.   MOLECULAR PSYCHIATRY

Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer’s Disease by Vitamin E and Selenium Trial (PREADViSE)

(2017) Richard J. Kryscio et al.   JAMA Neurology

Oxidative Stress: Mechanistic Insights into Inherited Mitochondrial Disorders and Parkinson’s Disease

(2017) Mesfer Al Shahrani et al.   Journal of Clinical Medicine

Creatine for neuroprotection in neurodegenerative disease: end of story?

(2016) Andreas Bender et al.   AMINO ACIDS

Melanin and neuromelanin binding of drugs and chemicals: toxicological implications

(2016) Oskar Karlsson et al.   ARCHIVES OF TOXICOLOGY

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Coenzyme Q10 for Patients with Parkinson';s Disease: A Systematic Review and Meta-Analysis

(2016) Ahmed Negida et al.   CNS & Neurological Disorders-Drug Targets

l-DOPA-induced dyskinesia and neuroinflammation: do microglia and astrocytes play a role?

(2016) Anna R. Carta et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Functional role of mitochondrial reactive oxygen species in physiology

(2016) Plamena R. Angelova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Advances in nanomedicine for the treatment of Alzheimer’s and Parkinson’s diseases

(2016) Sara Hernando et al.   Nanomedicine

The efficacy and safety of coenzyme Q10 in Parkinson’s disease: a meta-analysis of randomized controlled trials

(2016) Zhen-Guo Zhu et al.   NEUROLOGICAL SCIENCES

Nitric Oxide: Exploring the Contextual Link with Alzheimer’s Disease

(2016) Nicholas Asiimwe et al.   Oxidative Medicine and Cellular Longevity

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

(2016) Shanmugam Manoharan et al.   Oxidative Medicine and Cellular Longevity

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

(2016) Tianfang Jiang et al.   PROGRESS IN NEUROBIOLOGY

Chronic Inflammation Links Cancer and Parkinson’s Disease

(2016) Zhiming Li et al.   Frontiers in Aging Neuroscience

Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

(2015) Marian Valko et al.   ARCHIVES OF TOXICOLOGY

Oxidative stress and Parkinson's disease: New hopes in treatment with herbal antioxidants

(2015) Amir Sarrafchi et al.   CURRENT PHARMACEUTICAL DESIGN

Thr175-phosphorylated tau induces pathologic fibril formation via GSK3β-mediated phosphorylation of Thr231 in vitro

(2015) Alexander J. Moszczynski et al.   NEUROBIOLOGY OF AGING

Wnt3a protects SH-SY5Y cells against 6-hydroxydopamine toxicity by restoration of mitochondria function

(2015) Lei Wei et al.   Translational Neurodegeneration

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

The Centrality of Mitochondria in the Pathogenesis and Treatment of Parkinson's Disease

(2014) Angelique Camilleri et al.   CNS Neuroscience & Therapeutics

Aβ and tau toxicities in Alzheimer’s are linked via oxidative stress-induced p38 activation: Protective role of vitamin E

(2014) E. Giraldo et al.   Redox Biology

Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes

(2013) Huajun Jin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

L-Arginine and Nitric Oxide in CNS Function and Neurodegenerative Diseases

(2013) Mayur Virarkar et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs

(2013) Takumi Satoh et al.   FREE RADICAL BIOLOGY AND MEDICINE

3,4-Dihydroxybenzalacetone Protects Against Parkinson's Disease-Related Neurotoxin 6-OHDA Through Akt/Nrf2/Glutathione Pathway

(2013) Kei Gunjima et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway

(2013) Haiyan Lou et al.   NEUROPHARMACOLOGY

Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson’s disease in rats

(2013) S.S. Karuppagounder et al.   NEUROSCIENCE

Hyperphosphorylation of tau protein by calpain regulation in retina of Alzheimer's disease transgenic mouse

(2013) Haikang Zhao et al.   NEUROSCIENCE LETTERS

Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease

(2013) Fabiana Morroni et al.   NEUROTOXICOLOGY

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

(2013) Sudhakar Raja Subramaniam et al.   PROGRESS IN NEUROBIOLOGY

Bioinorganic Chemistry of Alzheimer’s Disease

(2012) Kasper P. Kepp   CHEMICAL REVIEWS

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

(2012) Michael H. Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Role of Free Radicals in the Aging Brain and Parkinson’s Disease: Convergence and Parallelism

(2012) Hemant Kumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseases

(2012) Mahesh Ramalingam et al.   JOURNAL OF NEURAL TRANSMISSION

Role of mitochondrial homeostasis and dynamics in Alzheimer's disease

(2012) J. Eva Selfridge et al.   NEUROBIOLOGY OF DISEASE

Effects of Panax ginseng in Neurodegenerative Diseases

(2012) Ik-Hyun Cho   Journal of Ginseng Research

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Photo-activated phase separation in giant vesicles made from different lipid mixtures

(2011) Christopher K. Haluska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease

(2011) Tito Calì et al.   BIOFACTORS

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Complex III-dependent superoxide production of brain mitochondria contributes to seizure-related ROS formation

(2010) Dominika Malinska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease☆

(2010) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Iron in neuronal function and dysfunction

(2010) Gabriela A. Salvador   BIOFACTORS

Preclinical Alzheimer disease: Brain oxidative stress, Aβ peptide and proteomics

(2010) Christopher D. Aluise et al.   NEUROBIOLOGY OF DISEASE

Caspase substrates and neurodegenerative diseases

(2009) Natasa Bulat et al.   BRAIN RESEARCH BULLETIN

The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease

(2009) Antonio Cuadrado et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease

(2009) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's disease

(2009) Lennart Mucke   NATURE

Alzheimer's disease, metal ions and metal homeostatic therapy

(2009) Paolo Zatta et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation

(2008) Han-Qing Chen et al.   NEUROSCIENCE LETTERS