Liquid Biopsy in Glioblastoma Management: From Current Research to Future Perspectives

A profile on cobas® EGFR Mutation Test v2 as companion diagnostic for first-line treatment of patients with non-small cell lung cancer

(2020) Susana Torres et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma

(2020) Antje Wick et al.   INVESTIGATIONAL NEW DRUGS

Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells

(2020) Rocco Lucero et al.   Cell Reports

Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes

(2020) Farshad Nassiri et al.   NATURE MEDICINE

The Role of Liquid Biopsies in Detecting Molecular Tumor Biomarkers in Brain Cancer Patients

(2020) Heena Sareen et al.   Cancers

Analysis of Serum miRNA in Glioblastoma Patients: CD44-Based Enrichment of Extracellular Vesicles Enhances Specificity for the Prognostic Signature

(2020) Theophilos Tzaridis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomal transfer of miR-1238 contributes to temozolomide-resistance in glioblastoma

(2019) Jianxing Yin et al.   EBioMedicine

Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid

(2019) Alexandra M. Miller et al.   NATURE

Tumor-educated platelets

(2019) Sjors G.J.G. In 't Veld et al.   BLOOD

Gene and microRNA Signatures Are Associated with the Development and Survival of Glioblastoma Patients

(2019) Qi Yang et al.   DNA AND CELL BIOLOGY

Hypoxic glioma cells-secreted exosomal miR-301a activates the Wnt/β-catenin signaling and promotes radiation resistance by targeting TCEAL7

(2019) Xiao Yue et al.   MOLECULAR THERAPY

Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges

(2019) Saenz-Antoñanzas et al.   Cancers

Clinical Utility of Plasma Cell-Free DNA in Adult Patients with Newly Diagnosed Glioblastoma: A Pilot Prospective Study

(2019) Stephen J. Bagley et al.   CLINICAL CANCER RESEARCH

MicroRNAs as biomarkers for human glioblastoma: progress and potential

(2018) Shi-wei Huang et al.   ACTA PHARMACOLOGICA SINICA

Detection of circulating tumour cell clusters in human glioblastoma

(2018) Ilona Krol et al.   BRITISH JOURNAL OF CANCER

The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients

(2018) Oliver A. Zill et al.   CLINICAL CANCER RESEARCH

Liquid Biopsy in Primary Brain Tumors: Looking for Stardust!

(2018) Maxime Fontanilles et al.   Current Neurology and Neuroscience Reports

Blood-based biomarkers for the diagnosis and monitoring of gliomas

(2018) Marcus A Zachariah et al.   NEURO-ONCOLOGY

A curcumin-loaded polymeric micelle as a carrier of a microRNA-21 antisense-oligonucleotide for enhanced anti-tumor effects in a glioblastoma animal model

(2018) Xiaonan Tan et al.   Biomaterials Science

Profiling circulating tumour cells and other biomarkers of invasive cancers

(2018) Mahla Poudineh et al.   Nature Biomedical Engineering

Exosomal transfer of miR-151a enhances chemosensitivity to temozolomide in drug-resistant glioblastoma

(2018) Ailiang Zeng et al.   CANCER LETTERS

MGMT promoter methylation status testing to guide therapy for glioblastoma: refining the approach based on emerging evidence and current challenges

(2018) Alireza Mansouri et al.   NEURO-ONCOLOGY

Understanding and Treating Glioblastoma

(2018) Wolfgang Wick et al.   NEUROLOGIC CLINICS

Epigenetic modulation of metabolism in glioblastoma

(2018) Zhen Dong et al.   SEMINARS IN CANCER BIOLOGY

Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy

(2018) Eshini Panditharatna et al.   CLINICAL CANCER RESEARCH

Current and future tools for determination and monitoring of isocitrate dehydrogenase status in gliomas

(2018) Alberto Picca et al.   CURRENT OPINION IN NEUROLOGY

Regorafenib compared with lomustine in patients with relapsed glioblastoma (REGOMA): a multicentre, open-label, randomised, controlled, phase 2 trial

(2018) Giuseppe Lombardi et al.   LANCET ONCOLOGY

Enhanced detection of circulating tumor DNA by fragment size analysis

(2018) Florent Mouliere et al.   Science Translational Medicine

BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

(2018) Kevin K Lin et al.   Cancer Discovery

Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non–Small Cell Lung Cancer

(2018) Charu Aggarwal et al.   JAMA Oncology

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma

(2017) Roger Stupp et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

MiR-223/PAX6 Axis Regulates Glioblastoma Stem Cell Proliferation and the Chemo Resistance to TMZ via Regulating PI3K/Akt Pathway

(2017) Bai-Sheng Huang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A microRNA signature from serum exosomes of patients with glioma as complementary diagnostic biomarker

(2017) Alessandra Santangelo et al.   JOURNAL OF NEURO-ONCOLOGY

Serum microRNA profiling in patients with glioblastoma: a survival analysis

(2017) Hua Zhao et al.   Molecular Cancer

Current and Emerging Applications of Droplet Digital PCR in Oncology

(2017) Susana Olmedillas-López et al.   Molecular Diagnosis & Therapy

Integrating liquid biopsies into the management of cancer

(2017) Giulia Siravegna et al.   Nature Reviews Clinical Oncology

Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients

(2017) Javier M Figueroa et al.   NEURO-ONCOLOGY

Low serum level of miR-485-3p predicts poor survival in patients with glioblastoma

(2017) Zhi-Qiang Wang et al.   PLoS One

A cerebrospinal fluid microRNA signature as biomarker for glioblastoma

(2017) Johnny C. Akers et al.   Oncotarget

Non-invasive detection of somatic mutations using next-generation sequencing in primary central nervous system lymphoma

(2017) Maxime Fontanilles et al.   Oncotarget

Technical Insights into Highly Sensitive Isolation and Molecular Characterization of Fixed and Live Circulating Tumor Cells for Early Detection of Tumor Invasion

(2017) Sophie Laget et al.   PLoS One

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

(2016) Yanfang Liu et al.   CANCER CELL

Glioblastoma: exosome and microRNA as novel diagnosis biomarkers

(2016) L Saadatpour et al.   CANCER GENE THERAPY

The Impacts of miRNAs in Glioblastoma Progression

(2016) Rasime Kalkan et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Nitrosoureas in the Management of Malignant Gliomas

(2016) Alba A. Brandes et al.   Current Neurology and Neuroscience Reports

Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid

(2016) Elena I. Pentsova et al.   JOURNAL OF CLINICAL ONCOLOGY

Downregulation of serum microRNA-205 as a potential diagnostic and prognostic biomarker for human glioma

(2016) Xiao Yue et al.   JOURNAL OF NEUROSURGERY

Dynamics of circulating hypoxia-mediated miRNAs and tumor response in patients with high-grade glioma treated with bevacizumab

(2016) Tali Siegal et al.   JOURNAL OF NEUROSURGERY

A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma

(2016) Alba A. Brandes et al.   NEURO-ONCOLOGY

Circulating tumor cell is a common property of brain glioma and promotes the monitoring system

(2016) Faliang Gao et al.   Oncotarget

Inhibition of miR-21 in glioma cells using catalytic nucleic acids

(2016) Agnieszka Belter et al.   Scientific Reports

Fragment Length of Circulating Tumor DNA

(2016) Hunter R. Underhill et al.   PLoS Genetics

Potential Diagnostic and Prognostic Value of Plasma Circulating MicroRNA-182 in Human Glioma

(2016) Yilei Xiao et al.   MEDICAL SCIENCE MONITOR

A Comparison of ddPCR and ARMS for detecting EGFR T790M status in ctDNA from advanced NSCLC patients with acquired EGFR-TKI resistance

(2016) Wenxian Wang et al.   Cancer Medicine

Prospective Validation of Rapid Plasma Genotyping for the Detection ofEGFRandKRASMutations in Advanced Lung Cancer

(2016) Adrian G. Sacher et al.   JAMA Oncology

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Time-Dependent Decay of mRNA and Ribosomal RNA during Platelet Aging and Its Correlation with Translation Activity

(2016) Catherine Angénieux et al.   PLoS One

Liquid biopsies in patients with diffuse glioma

(2015) Myron G. Best et al.   ACTA NEUROPATHOLOGICA

Circular RNA enrichment in platelets is a signature of transcriptome degradation

(2015) Abd A. Alhasan et al.   BLOOD

Serum microRNA-210 as a potential noninvasive biomarker for the diagnosis and prognosis of glioma

(2015) N-s Lai et al.   BRITISH JOURNAL OF CANCER

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics

(2015) Myron G. Best et al.   CANCER CELL

Epigenetics and cancer metabolism

(2015) Christelle Johnson et al.   CANCER LETTERS

Brain Tumor Mutations Detected in Cerebral Spinal Fluid

(2015) W. Pan et al.   CLINICAL CHEMISTRY

Plasma miR-185 as a predictive biomarker for prognosis of malignant glioma

(2015) Minghua Wu et al.   Journal of Cancer Research and Therapeutics

miR-21 Is Linked to Glioma Angiogenesis

(2015) Simon Kjær Hermansen et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Identification of microRNAs as novel biomarkers for glioma detection: A meta-analysis based on 11 articles

(2015) Shengtao Qu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Regulation of the genetic code in megakaryocytes and platelets

(2015) M. T. Rondina et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Diagnostic Value of Plasma and Urinary 2-Hydroxyglutarate to Identify Patients With Isocitrate Dehydrogenase-Mutated Glioma

(2015) G. Lombardi et al.   ONCOLOGIST

Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord

(2015) Yuxuan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

(2015) Valentina R. Minciacchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma

(2015) Huilin Shao et al.   Nature Communications

Enhanced detection and comprehensive in situ phenotypic characterization of circulating and disseminated heteroploid epithelial and glioma tumor cells

(2015) Feng Ge et al.   Oncotarget

A differentially expressed set of microRNAs in cerebro-spinal fluid (CSF) can diagnose CNS malignancies

(2015) Alessandra Drusco et al.   Oncotarget

RNA nanoparticle as a vector for targeted siRNA delivery into glioblastoma mouse model

(2015) Tae Jin Lee et al.   Oncotarget

Detection of Brain Tumor Cells in the Peripheral Blood by a Telomerase Promoter-Based Assay

(2014) Kelly M. MacArthur et al.   CANCER RESEARCH

miR-221/222 Confers Radioresistance in Glioblastoma Cells Through Activating Akt Independent of PTEN Status

(2014) W. Li et al.   CURRENT MOLECULAR MEDICINE

miRNA microarray reveals specific expression in the peripheral blood of glioblastoma patients

(2014) LUN DONG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MicroRNA-21 Promotes Glioblastoma Tumorigenesis by Down-regulating Insulin-like Growth Factor-binding Protein-3 (IGFBP3)

(2014) Chuan He Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liquid Biopsies: Genotyping Circulating Tumor DNA

(2014) Luis A. Diaz et al.   JOURNAL OF CLINICAL ONCOLOGY

Circulating MicroRNA Biomarkers for Glioma and Predicting Response to Therapy

(2014) Charlotte A. Tumilson et al.   MOLECULAR NEUROBIOLOGY

A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool

(2014) Lorea Manterola et al.   NEURO-ONCOLOGY

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

Hematogenous dissemination of glioblastoma multiforme

(2014) C. Muller et al.   Science Translational Medicine

Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression

(2014) J. P. Sullivan et al.   Cancer Discovery

Blood-Based Analyses of Cancer: Circulating Tumor Cells and Circulating Tumor DNA

(2014) D. A. Haber et al.   Cancer Discovery

Common features of microRNA target prediction tools

(2014) Sarah M. Peterson et al.   Frontiers in Genetics

Glioblastoma and Other Malignant Gliomas

(2013) Antonio Omuro   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Detection of MGMT, RASSF1A, p15INK4B, and p14ARF promoter methylation in circulating tumor-derived DNA of central nervous system cancer patients

(2013) Aleksandra Majchrzak-Celińska et al.   JOURNAL OF APPLIED GENETICS

Serum 2-Hydroxyglutarate Production in IDH1- and IDH2-Mutated De Novo Acute Myeloid Leukemia: A Study by the Acute Leukemia French Association Group

(2013) Maxime Janin et al.   JOURNAL OF CLINICAL ONCOLOGY

Exosomes in tumor microenvironment influence cancer progression and metastasis

(2013) Christoph Kahlert et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

miR-21 in the Extracellular Vesicles (EVs) of Cerebrospinal Fluid (CSF): A Platform for Glioblastoma Biomarker Development

(2013) Johnny C. Akers et al.   PLoS One

Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells

(2013) Cheryl CY Li et al.   RNA Biology

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Learning the molecular mechanisms of the reprogramming factors: let's start from microRNAs

(2012) Chao-Shun Yang et al.   Molecular BioSystems

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

(2012) Luis A. Diaz Jr et al.   NATURE

EORTC 26083 phase I/II trial of dasatinib in combination with CCNU in patients with recurrent glioblastoma

(2012) E. Franceschi et al.   NEURO-ONCOLOGY

MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity

(2012) N. M. Teplyuk et al.   NEURO-ONCOLOGY

Detection of IDH1 mutation in the plasma of patients with glioma

(2012) B. Boisselier et al.   NEUROLOGY

A Catalogue of Glioblastoma and Brain MicroRNAs Identified by Deep Sequencing

(2012) Dasong Hua et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Silencing of MicroRNA-21 Confers Radio-Sensitivity through Inhibition of the PI3K/AKT Pathway and Enhancing Autophagy in Malignant Glioma Cell Lines

(2012) Ho-Shin Gwak et al.   PLoS One

Circulating Tumor Cells and Circulating Tumor DNA

(2011) Catherine Alix-Panabières et al.   Annual Review of Medicine

Blood platelets contain tumor-derived RNA biomarkers

(2011) R. J. A. Nilsson et al.   BLOOD

Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity

(2011) S. Nagalla et al.   BLOOD

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

A specific miRNA signature in the peripheral blood of glioblastoma patients

(2011) Patrick Roth et al.   JOURNAL OF NEUROCHEMISTRY

The septic milieu triggers expression of spliced tissue factor mRNA in human platelets

(2011) M. T. RONDINA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades

(2011) I. Lavon et al.   NEURO-ONCOLOGY

A Ten-microRNA Expression Signature Predicts Survival in Glioblastoma

(2011) Sujaya Srinivasan et al.   PLoS One

Tumor-Derived Tissue Factor-Bearing Microparticles Are Associated With Venous Thromboembolic Events in Malignancy

(2009) J. I. Zwicker et al.   CLINICAL CANCER RESEARCH

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

(2009) Henry S. Friedman et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

MGMT promoter methylation in malignant gliomas: ready for personalized medicine?

(2009) Michael Weller et al.   Nature Reviews Neurology

Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device

(2009) A. H. Talasaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE