Liquid biopsies in patients with diffuse glioma

Mechanisms of intimate and long-distance cross-talk between glioma and myeloid cells: How to break a vicious cycle

(2014) Thomas Wurdinger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

International Society of Neuropathology-Haarlem Consensus Guidelines for Nervous System Tumor Classification and Grading

(2014) David N. Louis et al.   BRAIN PATHOLOGY

Evaluation of Eight Plasma Proteins as Candidate Blood-Based Biomarkers for Malignant Gliomas

(2014) Ryan P. Lange et al.   CANCER INVESTIGATION

Detection of Brain Tumor Cells in the Peripheral Blood by a Telomerase Promoter-Based Assay

(2014) Kelly M. MacArthur et al.   CANCER RESEARCH

MGMT promoter methylation in plasma of glioma patients receiving temozolomide

(2014) Valentina Fiano et al.   JOURNAL OF NEURO-ONCOLOGY

Clinical relevance of circulating cell-free microRNAs in cancer

(2014) Heidi Schwarzenbach et al.   Nature Reviews Clinical Oncology

Molecular analysis of circulating tumour cells—biology and biomarkers

(2014) Matthew G. Krebs et al.   Nature Reviews Clinical Oncology

A step towards clinical blood biomarkers of glioblastoma

(2014) Matthias Preusser   Nature Reviews Neurology

MGMT testing—the challenges for biomarker-based glioma treatment

(2014) Wolfgang Wick et al.   Nature Reviews Neurology

A neurocentric perspective on glioma invasion

(2014) Vishnu Anand Cuddapah et al.   NATURE REVIEWS NEUROSCIENCE

Invasion and proliferation kinetics in enhancing gliomas predict IDH1 mutation status

(2014) Anne L. Baldock et al.   NEURO-ONCOLOGY

A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool

(2014) Lorea Manterola et al.   NEURO-ONCOLOGY

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007-2011

(2014) Q. T. Ostrom et al.   NEURO-ONCOLOGY

A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

(2014) Mark R. Gilbert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma

(2014) Olivier L. Chinot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

Hematogenous dissemination of glioblastoma multiforme

(2014) C. Muller et al.   Science Translational Medicine

Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes

(2014) Danijela Koppers-Lalic et al.   Cell Reports

Circulating biomarkers of CNS tumors: an update

(2013) Aysegül Ilhan-Mutlu et al.   Biomarkers in Medicine

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

MC13-0072 Tumor perfusion during bevacizumab and irinotecan in recurrent glioblastoma: A multimodal approach

(2013) M. Eoli et al.   EUROPEAN JOURNAL OF CANCER

Detection of MGMT, RASSF1A, p15INK4B, and p14ARF promoter methylation in circulating tumor-derived DNA of central nervous system cancer patients

(2013) Aleksandra Majchrzak-Celińska et al.   JOURNAL OF APPLIED GENETICS

Use of Statins and the Risk of Death in Patients With Prostate Cancer

(2013) Oriana Yu et al.   JOURNAL OF CLINICAL ONCOLOGY

Detection of Serum Alu Element Hypomethylation for the Diagnosis and Prognosis of Glioma

(2013) Jian Chen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Blood-based biomarkers for malignant gliomas

(2013) Matthias Holdhoff et al.   JOURNAL OF NEURO-ONCOLOGY

Detection of EGFRvIII mutant DNA in the peripheral blood of brain tumor patients

(2013) Mohamad A. Salkeni et al.   JOURNAL OF NEURO-ONCOLOGY

GC/MS-based metabolomic analysis of cerebrospinal fluid (CSF) from glioma patients

(2013) Satoshi Nakamizo et al.   JOURNAL OF NEURO-ONCOLOGY

Phenotypical analysis, relation to malignancy and prognostic relevance of ICOS+T regulatory and dendritic cells in patients with gliomas

(2013) Konstantinos Gousias et al.   JOURNAL OF NEUROIMMUNOLOGY

Using the molecular classification of glioblastoma to inform personalized treatment

(2013) Adriana Olar et al.   JOURNAL OF PATHOLOGY

Cytokine Patterns in Brain Tumour Progression

(2013) Radu Albulescu et al.   MEDIATORS OF INFLAMMATION

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

(2013) Muhammed Murtaza et al.   NATURE

Liquid biopsy: monitoring cancer-genetics in the blood

(2013) Emily Crowley et al.   Nature Reviews Clinical Oncology

Proteomic studies of urinary biomarkers for prostate, bladder and kidney cancers

(2013) Steven L. Wood et al.   Nature Reviews Urology

Association of matrix metalloproteinase 2 plasma level with response and survival in patients treated with bevacizumab for recurrent high-grade glioma

(2013) Emeline Tabouret et al.   NEURO-ONCOLOGY

IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection

(2013) Jason Beiko et al.   NEURO-ONCOLOGY

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

(2013) Sarah-Jane Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prognostic Value of CD109+ Circulating Endothelial Cells in Recurrent Glioblastomas Treated with Bevacizumab and Irinotecan

(2013) Lucia Cuppini et al.   PLoS One

Circulating Endothelial Cells and Procoagulant Microparticles in Patients with Glioblastoma: Prognostic Value

(2013) Gaspar Reynés et al.   PLoS One

miR-21 in the Extracellular Vesicles (EVs) of Cerebrospinal Fluid (CSF): A Platform for Glioblastoma Biomarker Development

(2013) Johnny C. Akers et al.   PLoS One

Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation

(2013) T. T. Batchelor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

(2013) A. Sottoriva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicles as prospective carriers of oncogenic protein signatures in adult and paediatric brain tumours

(2013) Delphine Garnier et al.   PROTEOMICS

Osteopontin and splice variant expression level in human malignant glioma: Radiobiologic effects and prognosis after radiotherapy

(2013) Antje Güttler et al.   RADIOTHERAPY AND ONCOLOGY

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles

(2013) Walter W Chen et al.   Molecular Therapy-Nucleic Acids

Platelets and platelet-like particles mediate intercellular RNA transfer

(2012) A. Risitano et al.   BLOOD

RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls

(2012) Mikkel Noerholm et al.   BMC CANCER

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Plasma MicroRNA-21 Concentration May Be a Useful Biomarker in Glioblastoma Patients

(2012) Aysegül Ilhan-Mutlu et al.   CANCER INVESTIGATION

Circulating Tumor Cells: Liquid Biopsy of Cancer

(2012) C. Alix-Panabieres et al.   CLINICAL CHEMISTRY

Skeletal spread of an anaplastic astrocytoma (WHO grade III) and preservation of histopathological properties within metastases

(2012) T. Martens et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Epigenetic biomarkers of T-cells in human glioma

(2012) John K. Wiencke et al.   Epigenetics

New prognostic factors and calculators for outcome prediction in patients with recurrent glioblastoma: A pooled analysis of EORTC Brain Tumour Group phase I and II clinical trials

(2012) Thierry Gorlia et al.   EUROPEAN JOURNAL OF CANCER

Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers

(2012) C. D'Souza-Schorey et al.   GENES & DEVELOPMENT

Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas

(2012) Cuihua Yang et al.   INTERNATIONAL JOURNAL OF CANCER

Thrombin-cleaved Fragments of Osteopontin Are Overexpressed in Malignant Glial Tumors and Provide a Molecular Niche with Survival Advantage

(2012) Yasuto Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma specific miRNAs as predictive biomarkers for diagnosis and prognosis of glioma

(2012) Qiong Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Decrease in circulating endothelial progenitor cells in treated glioma patients

(2012) Elena Corsini et al.   JOURNAL OF NEURO-ONCOLOGY

Pre- and post-operative plasma glial fibrillary acidic protein levels in patients with newly diagnosed gliomas

(2012) Hatim Husain et al.   JOURNAL OF NEURO-ONCOLOGY

Primary brain tumours in adults

(2012) Damien Ricard et al.   LANCET

A Systematic Review of MicroRNA in Glioblastoma Multiforme: Micro-modulators in the Mesenchymal Mode of Migration and Invasion

(2012) Heidi G. Møller et al.   MOLECULAR NEUROBIOLOGY

Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

(2012) Huilin Shao et al.   NATURE MEDICINE

Diagnostic and therapeutic avenues for glioblastoma: no longer a dead end?

(2012) Shota Tanaka et al.   Nature Reviews Clinical Oncology

Insights into pediatric diffuse intrinsic pontine glioma through proteomic analysis of cerebrospinal fluid

(2012) Amanda M. Saratsis et al.   NEURO-ONCOLOGY

Use of magnetic perfusion-weighted imaging to determine epidermal growth factor receptor variant III expression in glioblastoma

(2012) Elana S. Tykocinski et al.   NEURO-ONCOLOGY

Personalized care in neuro-oncology coming of age: why we need MGMT and 1p/19q testing for malignant glioma patients in clinical practice

(2012) M. Weller et al.   NEURO-ONCOLOGY

Detection of IDH1 mutation in the plasma of patients with glioma

(2012) B. Boisselier et al.   NEUROLOGY

Exploratory investigation of eight circulating plasma markers in brain tumor patients

(2012) Aysegul Ilhan-Mutlu et al.   NEUROSURGICAL REVIEW

Genetics and pharmacogenomics of diffuse gliomas

(2012) H.F. van Thuijl et al.   PHARMACOLOGY & THERAPEUTICS

Proteins with Altered Levels in Plasma from Glioblastoma Patients as Revealed by iTRAQ-Based Quantitative Proteomic Analysis

(2012) Poonam Gautam et al.   PLoS One

Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA

(2012) T. Forshew et al.   Science Translational Medicine

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Application of immunosignatures to the assessment of Alzheimer's disease

(2011) Lucas Restrepo et al.   ANNALS OF NEUROLOGY

Blood platelets contain tumor-derived RNA biomarkers

(2011) R. J. A. Nilsson et al.   BLOOD

Neurospecific Proteins in the Serum of Patients with Brain Tumors

(2011) N. V. Lyubimova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Myeloid Biomarkers Associated with Glioblastoma Response to Anti-VEGF Therapy with Aflibercept

(2011) J. F. de Groot et al.   CLINICAL CANCER RESEARCH

The origins of glioma: E Pluribus Unum?

(2011) F. A. Siebzehnrubl et al.   GLIA

2-Hydroxyglutarate concentration in serum from patients with gliomas does not correlate with IDH1/2 mutation status or tumor size

(2011) David Capper et al.   INTERNATIONAL JOURNAL OF CANCER

Serum YKL-40 following resection for cerebral glioblastoma

(2011) Daniela Bernardi et al.   JOURNAL OF NEURO-ONCOLOGY

A specific miRNA signature in the peripheral blood of glioblastoma patients

(2011) Patrick Roth et al.   JOURNAL OF NEUROCHEMISTRY

Larger companies dominate cancer companion diagnostic approvals

(2011) Charles Schmidt   NATURE BIOTECHNOLOGY

MicroRNAs in body fluids—the mix of hormones and biomarkers

(2011) Maria Angelica Cortez et al.   Nature Reviews Clinical Oncology

Validation of new biomarkers in systemic autoimmune diseases

(2011) Maria G. Tektonidou et al.   Nature Reviews Rheumatology

Joint NCCTG and NABTC prognostic factors analysis for high-grade recurrent glioma

(2011) W. Wu et al.   NEURO-ONCOLOGY

Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades

(2011) I. Lavon et al.   NEURO-ONCOLOGY

Serum YKL-40 is a marker of prognosis and disease status in high-grade gliomas

(2011) F. M. Iwamoto et al.   NEURO-ONCOLOGY

Phase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastoma

(2011) Prakash Chinnaiyan et al.   NEURO-ONCOLOGY

Identification of microRNAs in the cerebrospinal fluid as biomarker for the diagnosis of glioma

(2011) A. Baraniskin et al.   NEURO-ONCOLOGY

Molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies

(2011) K. Masui et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Prognostic value of plasma d-dimer levels in patients with glioblastoma multiforme – Results from a pilot study

(2011) Matthias Hoke et al.   WIENER KLINISCHE WOCHENSCHRIFT

Molecular diagnostics of gliomas: the clinical perspective

(2010) Ghazaleh Tabatabai et al.   ACTA NEUROPATHOLOGICA

High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2010) R. Stupp et al.   ANNALS OF ONCOLOGY

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Identification of Potential Serum Biomarkers of Glioblastoma: Serum Osteopontin Levels Correlate with Poor Prognosis

(2010) P. Sreekanthreddy et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

AACR-FDA-NCI Cancer Biomarkers Collaborative Consensus Report: Advancing the Use of Biomarkers in Cancer Drug Development

(2010) S. N. Khleif et al.   CLINICAL CANCER RESEARCH

Auto-antibodies as Emergent Prognostic Markers and Possible Mediators of Ischemic Cardiovascular Diseases

(2010) P. Roux-Lombard et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Phase II Study of Cediranib, an Oral Pan–Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Recurrent Glioblastoma

(2010) Tracy T. Batchelor et al.   JOURNAL OF CLINICAL ONCOLOGY

Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group

(2010) Patrick Y. Wen et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification of diagnostic serum protein profiles of glioblastoma patients

(2010) Anja Elstner et al.   JOURNAL OF NEURO-ONCOLOGY

Circulating markers of angiogenesis, inflammation, and coagulation in patients with glioblastoma

(2010) Gaspar Reynés et al.   JOURNAL OF NEURO-ONCOLOGY

Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide

(2010) Elizabeth R. Gerstner et al.   JOURNAL OF NEURO-ONCOLOGY

Frequent abnormalities of the immune system in gliomas and correlation with the WHO grading system of malignancy

(2010) K. Gousias et al.   JOURNAL OF NEUROIMMUNOLOGY

Proteomic Identification of Haptoglobin α2 as a Glioblastoma Serum Biomarker: Implications in Cancer Cell Migration and Tumor Growth

(2010) Durairaj Mohan Kumar et al.   JOURNAL OF PROTEOME RESEARCH

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

(2010) Kaj Blennow et al.   Nature Reviews Neurology

Quantitative detection of multiple gene promoter hypermethylation in tumor tissue, serum, and cerebrospinal fluid predicts prognosis of malignant gliomas

(2010) B.-L. Liu et al.   NEURO-ONCOLOGY

Serum angiogenic profile of patients with glioblastoma identifies distinct tumor subtypes and shows that TIMP-1 is a prognostic factor

(2010) M. Crocker et al.   NEURO-ONCOLOGY

Plasma proteome profiling reveals biomarker patterns associated with prognosis and therapy selection in glioblastoma multiforme patients

(2010) Anders Carlsson et al.   Proteomics Clinical Applications

Peptide screening of cerebrospinal fluid in patients with glioblastoma multiforme

(2009) M.U. Schuhmann et al.   EJSO

Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome

(2009) Sophie Shnaper et al.   INTERNATIONAL JOURNAL OF CANCER

Matrix Metalloproteinases As Novel Biomarker s and Potential Therapeutic Targets in Human Cancer

(2009) Roopali Roy et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular Predictors of Progression-Free and Overall Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective Translational Study of the German Glioma Network

(2009) Michael Weller et al.   JOURNAL OF CLINICAL ONCOLOGY

Hepatocyte growth factor in cerebrospinal fluid is associated with mortality and recurrence of glioblastoma, and could be of prognostic value

(2009) Roberto Garcia-Navarrete et al.   JOURNAL OF NEURO-ONCOLOGY

Circulating endothelial progenitor cells in malignant gliomas

(2009) Neysan Rafat et al.   JOURNAL OF NEUROSURGERY

Microfluidic isolation and transcriptome analysis of serum microvesicles

(2009) Chihchen Chen et al.   LAB ON A CHIP

Cancer micrometastases

(2009) Klaus Pantel et al.   Nature Reviews Clinical Oncology

Biomarkers of response and resistance to antiangiogenic therapy

(2009) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Plasma IGFBP-2 levels predict clinical outcomes of patients with high-grade gliomas

(2009) Yi Lin et al.   NEURO-ONCOLOGY

P16 PROMOTER METHYLATION IN THE SERUM AS A BASIS FOR THE MOLECULAR DIAGNOSIS OF GLIOMAS

(2009) Toshihiko Wakabayashi et al.   NEUROSURGERY

SURROGATE MARKERS PREDICT ANGIOGENIC POTENTIAL AND SURVIVAL IN PATIENTS WITH GLIOBLASTOMA MULTIFORME

(2009) Jeffrey P. Greenfield et al.   NEUROSURGERY

Platelets actively sequester angiogenesis regulators

(2008) G. Lakka Klement et al.   BLOOD

The Evolution of Our Understanding on Glioma

(2008) Ana Martin-Villalba et al.   BRAIN PATHOLOGY

Incidence of early pseudo‐progression in a cohort of malignant glioma patients treated with chemoirradiation with temozolomide

(2008) Walter Taal et al.   CANCER

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

(2008) Xi Chen et al.   CELL RESEARCH

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

The Stem Cell Marker Prominin-1/CD133 on Membrane Particles in Human Cerebrospinal Fluid Offers Novel Approaches for Studying Central Nervous System Disease

(2007) Hagen B. Huttner et al.   STEM CELLS