The involvement of TRPV4 on the hypoxia-induced oxidative neurotoxicity and apoptosis in a neuronal cell line: Protective role of melatonin

Selenium and neurological diseases: Focus on peripheral pain and TRP channels

(2020) Mustafa Nazıroğlu et al.   Current Neuropharmacology

The Zinc-Finger Domain Containing Protein ZC4H2 Interacts with TRPV4, Enhancing Channel Activity and Turnover at the Plasma Membrane

(2020) Laura Vangeel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel

(2020) Yener Akyuva et al.   Scientific Reports

Melatonin and Selenium Suppress Docetaxel-Induced TRPV1 Activation, Neuropathic Pain and Oxidative Neurotoxicity in Mice

(2020) Kemal Ertilav et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Glutathione Depletion and Parkinsonian Neurotoxin MPP+-Induced TRPM2 Channel Activation Play Central Roles in Oxidative Cytotoxicity and Inflammation in Microglia

(2020) Kenan Yıldızhan et al.   MOLECULAR NEUROBIOLOGY

Curcumin Attenuates Hypoxia-Induced Oxidative Neurotoxicity, Apoptosis, Calcium, and Zinc Ion Influxes in a Neuronal Cell Line: Involvement of TRPM2 Channel

(2020) Hamit Hakan Armağan et al.   NEUROTOXICITY RESEARCH

Blockade of Transient Receptor Potential Vanilloid 4 Enhances Antioxidation after Myocardial Ischemia/Reperfusion

(2019) Qiongfeng Wu et al.   Oxidative Medicine and Cellular Longevity

Albumin evokes Ca2+-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin

(2019) Mustafa Nazıroğlu et al.   Scientific Reports

Curcumin enhances cisplatin-induced human laryngeal squamous cancer cell death through activation of TRPM2 channel and mitochondrial oxidative stress

(2019) Sinem Gökçe Kütük et al.   Scientific Reports

Zn2+ entry through the mitochondrial calcium uniporter is a critical contributor to mitochondrial dysfunction and neurodegeneration

(2019) Sung G. Ji et al.   EXPERIMENTAL NEUROLOGY

Reactive oxygen species induced Ca2+ influx via TRPV4 and microvascular endothelial dysfunction in the SU5416/hypoxia model of pulmonary arterial hypertension

(2018) Karthik Suresh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Melatonin and Oxidative Stress in the Diabetic State: Clinical Implications and Potential Therapeutic Applications

(2018) Javier Espino et al.   CURRENT MEDICINAL CHEMISTRY

Neuropathic Pain: Delving into the Oxidative Origin and the Possible Implication of Transient Receptor Potential Channels

(2018) Cristina Carrasco et al.   Frontiers in Physiology

Pretreatment-Etidronate Alleviates CoCl2 Induced-SH-SY5Y Cell Apoptosis via Decreased HIF-1α and TRPC5 Channel Proteins

(2018) Kai Li et al.   NEUROCHEMICAL RESEARCH

Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line

(2018) Haci Ahmet Deveci et al.   BIOMEDICINE & PHARMACOTHERAPY

Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis

(2017) Mengen Zhai et al.   JOURNAL OF PINEAL RESEARCH

The Effects of Oxygen and Treatments in Hypoxic Conditions in SH-SY5Y Cells

(2017) Young-Duck Cho et al.   SHOCK

Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia/reperfusion injury in mice

(2017) Qian Dong et al.   Scientific Reports

Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics

(2016) Lei Bao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

(2016) Md. Torequl Islam   NEUROLOGICAL RESEARCH

Enhanced Oxidative Stress Is Responsible for TRPV4-Induced Neurotoxicity

(2016) Zhiwen Hong et al.   Frontiers in Cellular Neuroscience

Different Contribution of Redox-Sensitive Transient Receptor Potential Channels to Acetaminophen-Induced Death of Human Hepatoma Cell Line

(2016) Heba Badr et al.   Frontiers in Pharmacology

Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways

(2015) P Jie et al.   Cell Death & Disease

Cerebrolysin protects PC12 cells from CoCl2-induced hypoxia employing GSK3β signaling

(2014) Kerstin Hartwig et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Activation of Transient Receptor Potential Vanilloid 4 is Involved in Neuronal Injury in Middle Cerebral Artery Occlusion in Mice

(2014) Pinghui Jie et al.   MOLECULAR NEUROBIOLOGY

Involvement of TRPV4 channels in Aβ40-induced hippocampal cell death and astrocytic Ca2+ signalling

(2014) Ji-Zhong Bai et al.   NEUROTOXICOLOGY

PP2A Ligand ITH12246 Protects against Memory Impairment and Focal Cerebral Ischemia in Mice

(2013) Silvia Lorrio et al.   ACS Chemical Neuroscience

Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells

(2013) S Carbajo-Pescador et al.   BRITISH JOURNAL OF CANCER

Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia

(2013) Ming-Wai Hung et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: The watchdog of villous trophoblast homeostasis against hypoxia/reoxygenation-induced oxidative stress and apoptosis

(2013) Dave Lanoix et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activation of Transient Receptor Potential Vanilloid 4 Increases NMDA-Activated Current in Hippocampal Pyramidal Neurons

(2013) Lin Li et al.   Frontiers in Cellular Neuroscience

Melatonin potentiates chemotherapy-induced cytotoxicity and apoptosis in rat pancreatic tumor cells

(2012) Abdulhadi C. Uguz et al.   JOURNAL OF PINEAL RESEARCH

Protein Kinase G Inhibits Flow-Induced Ca2+ Entry into Collecting Duct Cells

(2012) J. Du et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia

(2012) Olena Butenko et al.   PLoS One

Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling

(2011) Aaron H. Bubolz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension

(2011) Xiao-Ru Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TRPV4 Agonists and Antagonists

(2011) Fabien Vincent et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Urothelial cells produce hydrogen peroxide through the activation of Duox1

(2010) Ágnes Donkó et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin Reduces Apoptosis Induced by Calcium Signaling in Human Leukocytes: Evidence for the Involvement of Mitochondria and Bax Activation

(2010) Javier Espino et al.   JOURNAL OF MEMBRANE BIOLOGY

Synphilin-1 Enhances α-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death in a Sir2-Dependent Manner

(2010) Sabrina Büttner et al.   PLoS One

Melatonin ameliorates hippocampal nitric oxide production and large conductance calcium-activated potassium channel activity in chronic intermittent hypoxia

(2007) Y. W. Tjong et al.   JOURNAL OF PINEAL RESEARCH