Reactive oxygen species induced Ca2+ influx via TRPV4 and microvascular endothelial dysfunction in the SU5416/hypoxia model of pulmonary arterial hypertension

Isolation and characterization of endothelial-to-mesenchymal transition cells in pulmonary arterial hypertension

(2018) Toshio Suzuki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Traumatic Brain Injury Impairs Myogenic Constriction of Cerebral Arteries: Role of Mitochondria-Derived H2O2 and TRPV4-Dependent Activation of BKca Channels

(2018) Nikolett Szarka et al.   JOURNAL OF NEUROTRAUMA

A novel algorithm identifies stress-induced alterations in mitochondrial connectivity and inner membrane structure from confocal images

(2017) Mathieu Ouellet et al.   PLoS Computational Biology

Phosphorylation inactivation of endothelial nitric oxide synthesis in pulmonary arterial hypertension

(2016) Sudakshina Ghosh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target SlugCLINICAL PERSPECTIVE

(2016) Rachel K. Hopper et al.   CIRCULATION

Loss of Endothelial Nitric Oxide Synthase Promotes p25 Generation and Tau Phosphorylation in a Murine Model of Alzheimer’s DiseaseNovelty and Significance

(2016) Susan A. Austin et al.   CIRCULATION RESEARCH

O 2 sensing, mitochondria and ROS signaling: The fog is lifting

(2016) Gregory B. Waypa et al.   MOLECULAR ASPECTS OF MEDICINE

Earth Mover’s Distance (EMD): A True Metric for Comparing Biomarker Expression Levels in Cell Populations

(2016) Darya Y. Orlova et al.   PLoS One

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

(2016) Solene M. Evrard et al.   Nature Communications

Changes in cell shape are correlated with metastatic potential in murine and human osteosarcomas

(2016) Samanthe M. Lyons et al.   Biology Open

Quantitative analysis of rat adipose tissue cell recovery, and non-fat cell volume, in primary cell cultures

(2016) Floriana Rotondo et al.   PeerJ

Hydrogen peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4

(2015) Karthik Suresh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TRPV4 Is Required for Hypoxic Pulmonary Vasoconstriction

(2015) Neil M. Goldenberg et al.   ANESTHESIOLOGY

Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

(2015) B. Ranchoux et al.   CIRCULATION

TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis

(2015) Rachel G. Scheraga et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial dynamics in pulmonary arterial hypertension

(2015) John Ryan et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

(2015) Lu Long et al.   NATURE MEDICINE

Mitochondrial control by DRP1 in brain tumor initiating cells

(2015) Qi Xie et al.   NATURE NEUROSCIENCE

Automated Quantification and Integrative Analysis of 2D and 3D Mitochondrial Shape and Network Properties

(2014) Julie Nikolaisen et al.   PLoS One

Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1

(2013) Sarah Pisarcik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mitochondrial morphology transitions and functions: implications for retrograde signaling?

(2013) Martin Picard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

Targeting cell motility in pulmonary arterial hypertension

(2013) R. Paulin et al.   EUROPEAN RESPIRATORY JOURNAL

Physiological and Pathological Significance of Dynamin-Related Protein 1 (Drp1)-Dependent Mitochondrial Fission in the Nervous System

(2013) Bongki Cho et al.   Experimental Neurobiology

TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis

(2012) Li Ye et al.   CELL

Mitochondrial Fission Triggered by Hyperglycemia Is Mediated by ROCK1 Activation in Podocytes and Endothelial Cells

(2012) Wenjian Wang et al.   Cell Metabolism

Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription

(2012) A.-B. Al-Mehdi et al.   Science Signaling

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

(2012) Kevin S. Thorneloe et al.   Science Translational Medicine

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues

(2012) Alicia Lundby et al.   Nature Communications

Targeting Energetic Metabolism

(2011) Rubin M. Tuder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species

(2011) Randy J. Giedt et al.   FREE RADICAL BIOLOGY AND MEDICINE

TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling

(2011) A Fiorio Pla et al.   ONCOGENE

Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells

(2010) Iwona Fijalkowska et al.   AMERICAN JOURNAL OF PATHOLOGY

Abnormalities in Mitochondrial Structure in Cells from Patients with Bipolar Disorder

(2010) Anne M. Cataldo et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

(2009) Junko Wakabayashi et al.   JOURNAL OF CELL BIOLOGY

Role of Nox4 and Nox2 in Hyperoxia-Induced Reactive Oxygen Species Generation and Migration of Human Lung Endothelial Cells

(2008) Srikanth Pendyala et al.   ANTIOXIDANTS & REDOX SIGNALING