Glutathione Depletion and Parkinsonian Neurotoxin MPP+-Induced TRPM2 Channel Activation Play Central Roles in Oxidative Cytotoxicity and Inflammation in Microglia

Selenium and neurological diseases: Focus on peripheral pain and TRP channels

(2020) Mustafa Nazıroğlu et al.   Current Neuropharmacology

Curcumin diminishes cisplatin-induced apoptosis and mitochondrial oxidative stress through inhibition of TRPM2 channel signaling pathway in mouse optic nerve

(2020) Dilek Özkaya et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Gait deficits and loss of striatal tyrosine hydroxlase/trk-b are restored following 7,8-dihydroxyflavone treatment in a progressive mptp mouse model of parkinson’s disease

(2020) Michelle S. Massaquoi et al.   NEUROSCIENCE

The redox biology of redox-inert zinc ions

(2019) Wolfgang Maret   FREE RADICAL BIOLOGY AND MEDICINE

Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death

(2019) Xinfang An et al.   Cells

Activation of microglia synergistically enhances neurodegeneration caused by MPP+ in human SH-SY5Y cells

(2019) Zhilan Peng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation

(2019) Shu Yao et al.   Journal of Neuroimmune Pharmacology

N-acetyl-cysteine blunts 6-hydroxydopamine- and l-buthionine-sulfoximine-induced apoptosis in human mesenchymal stromal cells

(2019) A. R. Bonilla-Porras et al.   MOLECULAR BIOLOGY REPORTS

Mitochondrial oxidative stress-induced brain and hippocampus apoptosis decrease through modulation of caspase activity, Ca2+ influx and inflammatory cytokine molecular pathways in the docetaxel-treated mice by melatonin and selenium treatments

(2019) Zeki Serdar Ataizi et al.   METABOLIC BRAIN DISEASE

Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology

(2019) David K. Simon et al.   CLINICS IN GERIATRIC MEDICINE

TRPM2 channel regulates cytokines production in astrocytes and aggravates brain disorder during lipopolysaccharide-induced endotoxin sepsis

(2019) Tao Zhu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology

(2019) David H. Gutmann et al.   NEURON

Dopamine attenuates lipopolysaccharide-induced expression of proinflammatory cytokines by inhibiting the nuclear translocation of NF-κB p65 through the formation of dopamine quinone in microglia.

(2019) Yasuhiro Yoshioka et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TRPM2 Mediates Neutrophil Killing of Disseminated Tumor Cells

(2018) Maya Gershkovitz et al.   CANCER RESEARCH

TRPM2 dependence of ROS-induced NLRP3 activation in Alzheimer's disease

(2018) Malihe Aminzadeh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress

(2018) Jaime N. Guzman et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease

(2018) Jianhua Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures

(2018) Fillipe M. de Araújo et al.   NEUROTOXICOLOGY

Multiple molecular mechanisms form a positive feedback loop driving amyloid β42 peptide-induced neurotoxicity via activation of the TRPM2 channel in hippocampal neurons

(2018) Xin Li et al.   Cell Death & Disease

Impact of Dopamine Oxidation on Dopaminergic Neurodegeneration

(2018) Shun Zhang et al.   ACS Chemical Neuroscience

Protective effects of voltage-gated calcium channel antagonists against zinc toxicity in SN56 neuroblastoma cholinergic cells

(2018) Marlena Zyśk et al.   PLoS One

Acute maternal oxidant exposure causes susceptibility of the fetal brain to inflammation and oxidative stress

(2017) Feroz Akhtar et al.   Journal of Neuroinflammation

Intracellular zinc flux causes reactive oxygen species mediated mitochondrial dysfunction leading to cell death in Leishmania donovani

(2017) Anjali Kumari et al.   PLoS One

Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells

(2017) Sharifah Syed Mortadza et al.   Scientific Reports

Spontaneous Ca 2+ transients in mouse microglia

(2016) Laura Korvers et al.   CELL CALCIUM

Ovariectomy-Induced Mitochondrial Oxidative Stress, Apoptosis, and Calcium Ion Influx Through TRPA1, TRPM2, and TRPV1 Are Prevented by 17β-Estradiol, Tamoxifen, and Raloxifene in the Hippocampus and Dorsal Root Ganglion of Rats

(2016) Yener Yazğan et al.   MOLECULAR NEUROBIOLOGY

TRPM2 Promotes Neurotoxin MPP+/MPTP-Induced Cell Death

(2016) Yuyang Sun et al.   MOLECULAR NEUROBIOLOGY

Transient glutathione depletion in the substantia nigra compacta is associated with neuroinflammation in rats

(2016) Mei-Li Díaz-Hung et al.   NEUROSCIENCE

Inflammatory and Cell Death Pathways in Brain and Peripheral Blood in Parkinson’s Disease

(2015) Beatrice Macchi et al.   CNS & Neurological Disorders-Drug Targets

Cysteine-mediated redox signalling in the mitochondria

(2015) D. W. Bak et al.   Molecular BioSystems

Homocysteine and cytosolic GSH depletion induce apoptosis and oxidative toxicity through cytosolic calcium overload in the hippocampus of aged mice: Involvement of TRPM2 and TRPV1 channels

(2015) İ.S. Övey et al.   NEUROSCIENCE

Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease

(2013) Kuppusamy Tamilselvam et al.   Oxidative Medicine and Cellular Longevity

Factors regulating microglia activation

(2013) Katrin Kierdorf et al.   Frontiers in Cellular Neuroscience

Zonisamide Attenuates MPP(+)-Induced Oxidative Toxicity Through Modulation of Ca2+ Signaling and Caspase-3 Activity in Neuronal PC12 Cells

(2012) Vedat Ali Yürekli et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Molecular role of catalase on oxidative stress-induced Ca2+signaling and TRP cation channel activation in nervous system

(2012) Mustafa Nazıroğlu   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

TRPM2 channel protective properties of N-acetylcysteine on cytosolic glutathione depletion dependent oxidative stress and Ca2+ influx in rat dorsal root ganglion

(2012) C Özgül et al.   PHYSIOLOGY & BEHAVIOR

Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

(2012) Jillian C Belrose et al.   Molecular Brain

Mitochondrial Permeability Transition Pore Component Cyclophilin D Distinguishes Nigrostriatal Dopaminergic Death Paradigms in the MPTP Mouse Model of Parkinson's Disease

(2011) Bobby Thomas et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione Modulates Ca2+ Influx and Oxidative Toxicity Through TRPM2 Channel in Rat Dorsal Root Ganglion Neurons

(2011) Mustafa Nazıroğlu et al.   JOURNAL OF MEMBRANE BIOLOGY

Effects of Obovatol on GSH Depleted Glia-Mediated Neurotoxicity and Oxidative Damage

(2011) Moonhee Lee et al.   Journal of Neuroimmune Pharmacology

Ratiometric high-resolution imaging of JC-1 fluorescence reveals the subcellular heterogeneity of astrocytic mitochondria

(2011) Vera C. Keil et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Determination of Mitochondrial Membrane Potential and Reactive Oxygen Species in Live Rat Cortical Neurons

(2011) Dinesh C. Joshi et al.   Jove-Journal of Visualized Experiments

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

(2010) Moonhee Lee et al.   FASEB JOURNAL

A simple magnetic separation method for high-yield isolation of pure primary microglia

(2010) Richard Gordon et al.   JOURNAL OF NEUROSCIENCE METHODS

Glutathione Conjugates with Dopamine-Derived Quinones to Form Reactive or Non-Reactive Glutathione-Conjugates

(2010) Zhi Dong Zhou et al.   NEUROCHEMICAL RESEARCH

Apoptosis and glutathione: beyond an antioxidant

(2009) R Franco et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB)

(2008) K Togashi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of antioxidants on calcium influx through TRPM2 channels in transfected cells activated by hydrogen peroxide

(2008) Mustafa Nazıroğlu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid

(2006) Robert Kraft et al.   BRITISH JOURNAL OF PHARMACOLOGY