Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics

Targeting TRPM2 Channels Impairs Radiation-Induced Cell Cycle Arrest and Fosters Cell Death of T Cell Leukemia Cells in a Bcl-2-Dependent Manner

(2016) Dominik Klumpp et al.   Oxidative Medicine and Cellular Longevity

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

Ca2+ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance

(2015) Nicholas E. Hoffman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2′-phosphate

(2015) Balázs Tóth et al.   JOURNAL OF GENERAL PHYSIOLOGY

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

HIF2A and IGF2 Expression Correlates in Human Neuroblastoma Cells and Normal Immature Sympathetic Neuroblasts

(2015) Sofie Mohlin et al.   NEOPLASIA

Adrenergic Signaling Regulates Mitochondrial Ca2+ Uptake Through Pyk2-Dependent Tyrosine Phosphorylation of the Mitochondrial Ca2+ Uniporter

(2014) Jin O-Uchi et al.   ANTIOXIDANTS & REDOX SIGNALING

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

TRPM2 Channels Protect against Cardiac Ischemia-Reperfusion Injury

(2014) Barbara A. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Splice Variant of the Human Ion Channel TRPM2 Modulates Neuroblastoma Tumor Growth through Hypoxia-inducible Factor (HIF)-1/2α

(2014) Shu-jen Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Role of TRPM2 in cell proliferation and susceptibility to oxidative stress

(2013) Shu-jen Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury

(2013) Barbara A. Miller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The molecular hug between the ER and the mitochondria

(2013) Benoît Kornmann   CURRENT OPINION IN CELL BIOLOGY

Targeting SOD1 reduces experimental non–small-cell lung cancer

(2013) Andrea Glasauer et al.   JOURNAL OF CLINICAL INVESTIGATION

Endoplasmic reticulum-associated mitochondria-cortex tether functions in the distribution and inheritance of mitochondria

(2013) L. L. Lackner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

(2011) Daniel Tello et al.   Cell Metabolism

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation

(2011) Anke Di et al.   NATURE IMMUNOLOGY

Bnip3 as a Dual Regulator of Mitochondrial Turnover and Cell Death in the Myocardium

(2011) Åsa B. Gustafsson   PEDIATRIC CARDIOLOGY

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

(2011) A. T. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes

(2011) H. Knowles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange

(2010) JuFang Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Identification of Direct and Indirect Effectors of the Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel

(2010) Balázs Tóth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification

(2010) John G. Starkus et al.   JOURNAL OF PHYSIOLOGY-LONDON

PERSPECTIVES: Permeating proton found guilty in compromising TRPM2 channel activity

(2010) László Csanády   JOURNAL OF PHYSIOLOGY-LONDON

Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture

(2010) Ji-Zhong Bai et al.   NEUROTOXICOLOGY

HIF-1  and HIF-2  Are Differentially Regulated In vivo in Neuroblastoma: High HIF-1  Correlates Negatively to Advanced Clinical Stage and Tumor Vascularization

(2009) R. Noguera et al.   CLINICAL CANCER RESEARCH

Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity

(2009) Jianyang Du et al.   JOURNAL OF GENERAL PHYSIOLOGY

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Intracellular calcium activates TRPM2 and its alternative spliced isoforms

(2009) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional adaptation of neuroblastoma cells to hypoxia

(2008) Erik Fredlund et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

Identification of novel sense and antisense transcription at the TRPM2 locus in cancer

(2008) Ugo Orfanelli et al.   CELL RESEARCH

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Pore Residues Engaged in Determining Divalent Cationic Permeation in Transient Receptor Potential Melastatin Subtype Channel 2

(2008) Rong Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Poly(ADP-ribose) Polymerase PARP-1 Is Required for Oxidative Stress-induced TRPM2 Activation in Lymphocytes

(2008) Ben Buelow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered functional properties of a TRPM2 variant in Guamanian ALS and PD

(2008) M. C. Hermosura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

(2008) Gregg L. Semenza   SEMINARS IN CANCER BIOLOGY

Role of TRPM2 Channel in Mediating H 2 O 2 -Induced Ca 2+ Entry and Endothelial Hyperpermeability

(2007) Claudie M. Hecquet et al.   CIRCULATION RESEARCH