A multilayered immune system through the lens of unconventional T cells

Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCRαβ Clonotypes with Potent Antimicrobial Responses

(2020) Liyen Loh et al.   JOURNAL OF IMMUNOLOGY

Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

(2020) Michael D. Crowther et al.   NATURE IMMUNOLOGY

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

(2020) Jérôme Le Nours et al.   SCIENCE

The unconventional role of HLA-E: The road less traveled

(2020) Emma J. Grant et al.   MOLECULAR IMMUNOLOGY

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

(2020) Lauren J. Howson et al.   Science Immunology

MAIT Cell Development and Functions: the Microbial Connection

(2020) François Legoux et al.   IMMUNITY

Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells

(2020) S. Harsha Krovi et al.   Nature Communications

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

(2019) Toufic Mayassi et al.   CELL

Tissue-Resident T Cells and Other Resident Leukocytes

(2019) David Masopust et al.   Annual Review of Immunology

Capturing the antigen landscape: HLA-E, CD1 and MR1

(2019) Graham Ogg et al.   CURRENT OPINION IN IMMUNOLOGY

Microbial metabolites control the thymic development of mucosal-associated invariant T cells

(2019) François Legoux et al.   SCIENCE

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

(2019) Timothy S.C. Hinks et al.   Cell Reports

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

(2019) Michael G. Constantinides et al.   SCIENCE

An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer

(2019) Yin Wu et al.   Science Translational Medicine

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

(2019) H.-F. Koay et al.   Science Immunology

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells

(2018) Mauro Gaya et al.   CELL

Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair

(2018) Jonathan L. Linehan et al.   CELL

Unconventional T Cell Targets for Cancer Immunotherapy

(2018) Dale I. Godfrey et al.   IMMUNITY

Human intraepithelial lymphocytes

(2018) Toufic Mayassi et al.   Mucosal Immunology

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids

(2018) Kwok S. Wun et al.   NATURE IMMUNOLOGY

HCMV triggers frequent and persistent UL40-specific unconventional HLA-E-restricted CD8 T-cell responses with potential autologous and allogeneic peptide recognition

(2018) Nicolas Jouand et al.   PLoS Pathogens

T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1b with TAP-Independent Peptides Are Semi-Invariant Lymphocytes

(2018) Elien M. Doorduijn et al.   Frontiers in Immunology

The Diverse Family of MR1-Restricted T Cells

(2018) Nicholas A. Gherardin et al.   JOURNAL OF IMMUNOLOGY

The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness

(2018) Daisy Melandri et al.   NATURE IMMUNOLOGY

MAIT cells contribute to protection against lethal influenza infection in vivo

(2018) Bonnie van Wilgenburg et al.   Nature Communications

MHC Ib molecule Qa-1 presents Mycobacterium tuberculosis peptide antigens to CD8+ T cells and contributes to protection against infection

(2017) Yao Bian et al.   PLoS Pathogens

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

(2016) Rafael Di Marco Barros et al.   CELL

Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response

(2016) Stephanie Gras et al.   IMMUNITY

Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition

(2016) Nicholas A. Gherardin et al.   IMMUNITY

Evolution of innate-like T cells and their selection by MHC class I-like molecules

(2016) Eva-Stina Edholm et al.   IMMUNOGENETICS

MAIT, MR1, microbes and riboflavin: a paradigm for the co-evolution of invariant TCRs and restricting MHCI-like molecules?

(2016) Stanislas Mondot et al.   IMMUNOGENETICS

Restricting nonclassical MHC genes coevolve with TRAV genes used by innate-like T cells in mammals

(2016) Pierre Boudinot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell receptor recognition of CD1b presenting a mycobacterial glycolipid

(2016) Stephanie Gras et al.   Nature Communications

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

(2015) Jamie Rossjohn et al.   Annual Review of Immunology

Coevolution of T-cell receptors with MHC and non-MHC ligands

(2015) Caitlin D. Castro et al.   IMMUNOLOGICAL REVIEWS

A bird's eye view of NK cell receptor interactions with their MHC class I ligands

(2015) Philippa M. Saunders et al.   IMMUNOLOGICAL REVIEWS

αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands

(2015) Richard W Birkinshaw et al.   NATURE IMMUNOLOGY

The burgeoning family of unconventional T cells

(2015) Dale I Godfrey et al.   NATURE IMMUNOLOGY

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

(2015) Dennis X Beringer et al.   NATURE IMMUNOLOGY

Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire

(2015) Tanya Dimova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated T Cell Receptor Signaling Identifies a Thymic Precursor to the TCRαβ+CD4−CD8β− Intraepithelial Lymphocyte Lineage

(2014) Benjamin D. McDonald et al.   IMMUNITY

αβT Cell Receptors Expressed by CD4−CD8αβ− Intraepithelial T Cells Drive Their Fate into a Unique Lineage with Unusual MHC Reactivities

(2014) Sofia Mayans et al.   IMMUNITY

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells

(2014) Sidonia B.G. Eckle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: The Mechanism of Invariant NKT Cell Responses to Viral Danger Signals

(2014) A. J. Tyznik et al.   JOURNAL OF IMMUNOLOGY

A committed precursor to innate lymphoid cells

(2014) Michael G. Constantinides et al.   NATURE

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

(2014) Alexandra J. Corbett et al.   NATURE

Persistence of skin-resident memory T cells within an epidermal niche

(2014) A. Zaid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adaptable Major Histocompatibility Complex (MHC) Fold: Structure and Function of Nonclassical and MHC Class I–Like Molecules

(2013) Erin J. Adams et al.   Annual Review of Immunology

Crystal Structure of Vδ1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human γδ T Cells

(2013) Adrienne M. Luoma et al.   IMMUNITY

Origin, trafficking, and intraepithelial fate of gut-tropic T cells

(2013) Delphine Guy-Grand et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Double Positive Thymocytes Select Mucosal-Associated Invariant T Cells

(2013) N. Seach et al.   JOURNAL OF IMMUNOLOGY

A conserved human T cell population targets mycobacterial antigens presented by CD1b

(2013) Ildiko Van Rhijn et al.   NATURE IMMUNOLOGY

CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens

(2013) Annemieke de Jong et al.   NATURE IMMUNOLOGY

CD1d-lipid antigen recognition by the γδ TCR

(2013) Adam P Uldrich et al.   NATURE IMMUNOLOGY

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

(2013) Onisha Patel et al.   Nature Communications

Ex-vivoanalysis of human Natural Killer T cells demonstrates heterogeneity between tissues and within established CD4+and CD4−subsets

(2012) A. C. Chan et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Human and Mouse Type I Natural Killer T Cell Antigen Receptors Exhibit Different Fine Specificities for CD1d-Antigen Complex

(2012) Kwok S. Wun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAP Is Required for the Development of Innate Phenotype in H2-M3-Restricted CD8+ T Cells

(2012) Y. Bediako et al.   JOURNAL OF IMMUNOLOGY

MR1 presents microbial vitamin B metabolites to MAIT cells

(2012) Lars Kjer-Nielsen et al.   NATURE

Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor

(2012) Onisha Patel et al.   NATURE IMMUNOLOGY

Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens

(2012) Enrico Girardi et al.   NATURE IMMUNOLOGY

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

Innate signals overcome acquired TCR signaling pathway regulation and govern the fate of human CD161hi CD8 + semi-invariant T cells

(2011) C. J. Turtle et al.   BLOOD

Host Defense Pathways: Role of Redundancy and Compensation in Infectious Disease Phenotypes

(2011) Simone Nish et al.   IMMUNITY

TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms

(2011) O. Y. Borbulevych et al.   JOURNAL OF IMMUNOLOGY

Skint-1 is a highly specific, unique selecting component for epidermal T cells

(2011) S. D. Barbee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Intraepithelial T Cell Response to NKG2D-Ligands Links Lymphoid Stress Surveillance to Atopy

(2011) J. Strid et al.   SCIENCE

Regulation of self-tolerance by Qa-1-restricted CD8+ regulatory T cells

(2011) Hye-Jung Kim et al.   SEMINARS IN IMMUNOLOGY

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

(2010) Marielle C. Gold et al.   PLOS BIOLOGY

The NKG2D ligand ULBP4 binds to TCR 9/ 2 and induces cytotoxicity to tumor cells through both TCR   and NKG2D

(2009) Y. Kong et al.   BLOOD

A role for human skin–resident T cells in wound healing

(2009) Antoine Toulon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The nonpolymorphic MHC Qa-1bmediates CD8+T cell surveillance of antigen-processing defects

(2009) Cláudia C. Oliveira et al.   JOURNAL OF EXPERIMENTAL MEDICINE

From evolutionary genetics to human immunology: how selection shapes host defence genes

(2009) Luis B. Barreiro et al.   NATURE REVIEWS GENETICS

Origin and evolution of the adaptive immune system: genetic events and selective pressures

(2009) Martin F. Flajnik et al.   NATURE REVIEWS GENETICS

Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense

(2009) Luis B. Barreiro et al.   PLoS Genetics

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

The Transcription Factor PLZF Directs the Effector Program of the NKT Cell Lineage

(2008) Adam K. Savage et al.   IMMUNITY

Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis

(2008) Jessica Strid et al.   NATURE IMMUNOLOGY

NK Cell–Like Behavior of Vα14i NK T Cells during MCMV Infection

(2008) Johnna D. Wesley et al.   PLoS Pathogens