HCMV triggers frequent and persistent UL40-specific unconventional HLA-E-restricted CD8 T-cell responses with potential autologous and allogeneic peptide recognition

Definitions of Cytomegalovirus Infection and Disease in Transplant Patients for Use in Clinical Trials: Table 1.

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A new perspective of the structural complexity of HCMV-specific T-cell responses

(2016) Andrew Sylwester et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

(2016) S. G. Hansen et al.   SCIENCE

Molecular characterization of HCMV-specific immune responses: Parallels between CD8+T cells, CD4+T cells, and NK cells

(2015) Felipe A. Vieira Braga et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The diversity of the HLA-E-restricted peptide repertoire explains the immunological impact of the Arg107Gly mismatch

(2015) Alexander A. Celik et al.   IMMUNOGENETICS

The Presence of HLA-E-Restricted, CMV-Specific CD8+ T Cells in the Blood of Lung Transplant Recipients Correlates with Chronic Allograft Rejection

(2015) Lucy C. Sullivan et al.   PLoS One

Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options

(2015) Vijayakumar Velu et al.   Retrovirology

Human CD8+ T-cells Recognizing Peptides from Mycobacterium tuberculosis (Mtb) Presented by HLA-E Have an Unorthodox Th2-like, Multifunctional, Mtb Inhibitory Phenotype and Represent a Novel Human T-cell Subset

(2015) Krista E. van Meijgaarden et al.   PLoS Pathogens

HLA-E: Presentation of a Broader Peptide Repertoire Impacts the Cellular Immune Response—Implications on HSCT Outcome

(2015) Thomas Kraemer et al.   Stem Cells International

Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response

(2015) Ryan J. Martinez et al.   Frontiers in Immunology

PD-1 expression conditions T cell avidity within an antigen-specific repertoire

(2015) Sylvain Simon et al.   OncoImmunology

IL-12–producing monocytes and HLA-E control HCMV-driven NKG2C+ NK cell expansion

(2014) Alexander Rölle et al.   JOURNAL OF CLINICAL INVESTIGATION

CMV: Prevention, Diagnosis and Therapy

(2013) C. N. Kotton   AMERICAN JOURNAL OF TRANSPLANTATION

Cytomegalovirus in Solid Organ Transplantation

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Multimer monitoring of CMV-specific T cells in research and in clinical applications

(2013) Sylvia Borchers et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Polymorphism in Human Cytomegalovirus UL40 Impacts on Recognition of Human Leukocyte Antigen-E (HLA-E) by Natural Killer Cells

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The impact of donor CMV infection on kidney graft outcome

(2013) Ellen F. Carney   Nature Reviews Nephrology

State-of-the-Art Monitoring of Cytomegalovirus-Specific Cell-Mediated Immunity After Organ Transplant: A Primer for the Clinician

(2012) A. Egli et al.   CLINICAL INFECTIOUS DISEASES

Human Cytomegalovirus UL40 Signal Peptide Regulates Cell Surface Expression of the NK Cell Ligands HLA-E and gpUL18

(2012) V. Prod'homme et al.   JOURNAL OF IMMUNOLOGY

HLA-E-Restricted Cross-Recognition of Allogeneic Endothelial Cells by CMV-Associated CD8 T Cells: A Potential Risk Factor following Transplantation

(2012) Mathilde Allard et al.   PLoS One

Regulation of self-tolerance by Qa-1-restricted CD8+ regulatory T cells

(2011) Hye-Jung Kim et al.   SEMINARS IN IMMUNOLOGY

The emerging role of cytomegalovirus in driving immune senescence: a novel therapeutic opportunity for improving health in the elderly

(2010) Paul Moss   CURRENT OPINION IN IMMUNOLOGY

The Emerging Role of HLA-E-Restricted CD8+T Lymphocytes in the Adaptive Immune Response to Pathogens and Tumors

(2010) Gabriella Pietra et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The Rapid Induction of HLA-E Is Essential for the Survival of Antigen-Activated Naive CD4 T Cells from Attack by NK Cells

(2010) S. Takao et al.   JOURNAL OF IMMUNOLOGY

The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress

(2010) Thorbald van Hall et al.   MICROBES AND INFECTION

Tricks with tetramers: how to get the most from multimeric peptide-MHC

(2009) Linda Wooldridge et al.   IMMUNOLOGY

Human NK cells can control CMV infection in the absence of T cells

(2008) T. W. Kuijpers et al.   BLOOD

CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence

(2008) Emma J. Petrie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cellular normalization of viral DNA loads on whole blood improves the clinical management of cytomegalovirus or Epstein Barr virus infections in the setting of pre-emptive therapy

(2008) Céline Bressollette-Bodin et al.   JOURNAL OF MEDICAL VIROLOGY

CD8 T-cell-based immunotherapy of cytomegalovirus infection: “proof of concept” provided by the murine model

(2008) Rafaela Holtappels et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

The major histocompatibility complex class Ib molecule HLA-E at the interface between innate and adaptive immunity

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