Probing PIEZO1 Localization upon Activation Using High-Resolution Atomic Force and Confocal Microscopy

Non-uniform distribution of myosin-mediated forces governs red blood cell membrane curvature through tension modulation

(2020) Haleh Alimohamadi et al.   PLoS Computational Biology

Disruption of membrane cholesterol organization impairs the activity of PIEZO1 channel clusters

(2020) Pietro Ridone et al.   JOURNAL OF GENERAL PHYSIOLOGY

A dietary fatty acid counteracts neuronal mechanical sensitization

(2020) Luis O. Romero et al.   Nature Communications

Discoveries in structure and physiology of mechanically activated ion channels

(2020) J. M. Kefauver et al.   NATURE

Levering Mechanically Activated Piezo Channels for Potential Pharmacological Intervention

(2019) Bailong Xiao   Annual Review of Pharmacology and Toxicology

PIEZO1-Mediated Currents Are Modulated by Substrate Mechanics

(2019) Navid Bavi et al.   ACS Nano

Amphipathic molecules modulate PIEZO1 activity

(2019) Charles D. Cox et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1

(2019) Wesley M. Botello-Smith et al.   Nature Communications

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection

(2018) Shang Ma et al.   CELL

Structure and mechanogating mechanism of the Piezo1 channel

(2018) Qiancheng Zhao et al.   NATURE

A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel

(2018) Yanfeng Wang et al.   Nature Communications

Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1

(2018) Jerome J. Lacroix et al.   Nature Communications

Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation

(2018) Masaki Tsuchiya et al.   Nature Communications

Super-Resolution Microscopy Reveals the Native Ultrastructure of the Erythrocyte Cytoskeleton

(2018) Leiting Pan et al.   Cell Reports

Nanoscale membrane architecture of healthy and pathological red blood cells

(2018) Andra C. Dumitru et al.   Nanoscale Horizons

A Model of Piezo1-Based Regulation of Red Blood Cell Volume

(2018) Saša Svetina et al.   BIOPHYSICAL JOURNAL

Mechanical stretch triggers rapid epithelial cell division through Piezo1

(2017) S. A. Gudipaty et al.   NATURE

Structure of the mechanically activated ion channel Piezo1

(2017) Kei Saotome et al.   NATURE

How cells channel their stress: Interplay between Piezo1 and the cytoskeleton

(2017) Jamison L. Nourse et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structure-based membrane dome mechanism for Piezo mechanosensitivity

(2017) Yusong R Guo et al.   eLife

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

(2016) Charles D. Cox et al.   Nature Communications

Anatomy of the red cell membrane skeleton: unanswered questions

(2015) S. E. Lux   BLOOD

Architecture of the mammalian mechanosensitive Piezo1 channel

(2015) Jingpeng Ge et al.   NATURE

Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia

(2015) Viktor Lukacs et al.   Nature Communications

Chemical activation of the mechanotransduction channel Piezo1

(2015) Ruhma Syeda et al.   eLife

Piezo1 links mechanical forces to red blood cell volume

(2015) Stuart M Cahalan et al.   eLife

Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension

(2015) Amanda H Lewis et al.   eLife

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

The force-from-lipid (FFL) principle of mechanosensitivity, at large and in elements

(2014) Jinfeng Teng et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ion channels to cytoskeleton connection as potential mechanism of mechanosensitivity

(2013) Boris Martinac   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1

(2013) C. Bae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels

(2013) Juliette Albuisson et al.   Nature Communications

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

(2012) R. Zarychanski et al.   BLOOD

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

Native Ultrastructure of the Red Cell Cytoskeleton by Cryo-Electron Tomography

(2011) Andrea Nans et al.   BIOPHYSICAL JOURNAL

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE