Synthesis and Antiviral Evaluation of Nucleoside Analogues Bearing One Pyrimidine Moiety and Two D-Ribofuranosyl Residues

A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19

(2020) Steffen Jockusch et al.   ANTIVIRAL RESEARCH

Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase, a Key Drug Target for COVID-19

(2020) Minchen Chien et al.   JOURNAL OF PROTEOME RESEARCH

Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment

(2020) Victoria C. Yan et al.   ACS Medicinal Chemistry Letters

Synthesis of 1,2,3-triazolyl nucleoside analogues and their antiviral activity

(2020) Olga V. Andreeva et al.   MOLECULAR DIVERSITY

Antimicrobial and cytotoxic effects of ammonium derivatives of diterpenoids steviol and isosteviol

(2020) Alexandra D. Voloshina et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of novel 1,2,3-triazolyl nucleoside analogues bearing uracil, 6-methyluracil, 3,6-dimethyluracil, thymine, and quinazoline-2,4-dione moieties

(2019) Olga V. Andreeva et al.   TETRAHEDRON LETTERS

The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold

(2018) Katherine L. Seley-Radtke et al.   ANTIVIRAL RESEARCH

Isosteric ribavirin analogues: Synthesis and antiviral activities

(2018) Nikolay I. Zhurilo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evidence for Novel Action at the Cell-Binding Site of Human Angiogenin Revealed by Heteronuclear NMR Spectroscopy, in silico and in vivo Studies

(2018) Demetra S. M. Chatzileontiadou et al.   ChemMedChem

Synthesis of 4′-Substituted Purine 2′-Deoxynucleosides and Their Activity against Human Immunodeficiency Virus Type 1 and Hepatitis B Virus

(2018) Satoru Kohgo et al.   ChemistrySelect

Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit

(2016) Satoshi Fudo et al.   BIOCHEMISTRY

Recent Trends in Nucleotide Synthesis

(2016) Béatrice Roy et al.   CHEMICAL REVIEWS

Approved Antiviral Drugs over the Past 50 Years

(2016) Erik De Clercq et al.   CLINICAL MICROBIOLOGY REVIEWS

Design, synthesis, anticancer, antimicrobial activities and molecular docking studies of theophylline containing acetylenes and theophylline containing 1,2,3-triazoles with variant nucleoside derivatives

(2016) Radhakrishnam Raju Ruddarraju et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design

(2016) Annelies Stevaert et al.   MEDICINAL RESEARCH REVIEWS

5-(4-alkyl-1,2,3-triazol-1-yl)methyl derivatives of 2′-deoxyuridine as inhibitors of viral and bacterial growth

(2016) L. A. Alexandrova et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin

(2015) Demetra S.M. Chatzileontiadou et al.   BIOORGANIC CHEMISTRY

Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives

(2015) Krasimira T. Petrova et al.   CARBOHYDRATE RESEARCH

Structure and inhibition of EV-D68, a virus that causes respiratory illness in children

(2015) Y. Liu et al.   SCIENCE

Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors

(2015) Nicolino Pala et al.   ACS Medicinal Chemistry Letters

The RNA-dependent RNA polymerase of the influenza A virus

(2014) Thomas M Stubbs et al.   Future Virology

Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2013)

(2013) M. J. Adams et al.   ARCHIVES OF VIROLOGY

Inhibition of Mycobacterium tuberculosis strains H37Rv and MDR MS-115 by a new set of C5 modified pyrimidine nucleosides

(2013) Eduard R. Shmalenyuk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Click fleximers: a modular approach to purine base-expanded ribonucleoside analogues

(2012) André H. St. Amant et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

Design, synthesis, and anticancer activities of novel perfluoroalkyltriazole-appended 2′-deoxyuridines

(2010) Sun Min Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2′-deoxyuridines and their antiviral evaluation

(2010) Aurélien Montagu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structures of influenza A proteins and insights into antiviral drug targets

(2010) Kalyan Das et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Click chemistry reactions in medicinal chemistry: Applications of the 1,3-dipolar cycloaddition between azides and alkynes

(2007) Gian Cesare Tron et al.   MEDICINAL RESEARCH REVIEWS