The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design

Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase

(2016) Shuofeng Yuan et al.   ANTIVIRAL RESEARCH

Meeting report: 4th ISIRV antiviral group conference: Novel antiviral therapies for influenza and other respiratory viruses

(2016) Jennifer L. McKimm-Breschkin et al.   ANTIVIRAL RESEARCH

Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents

(2016) Cai Lin et al.   ANTIVIRAL RESEARCH

Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit

(2016) Satoshi Fudo et al.   BIOCHEMISTRY

Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases

(2016) Juan Reguera et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA–PB1 Protein–Protein Interaction: Structure–Activity Relationships Exploration with the Aid of Molecular Modeling

(2016) Iuni M. L. Trist et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues

(2016) Guangyi Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Polymerase Acidic Protein–Basic Protein 1 (PA–PB1) Protein–Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics

(2016) Serena Massari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains

(2016) Eric Thierry et al.   MOLECULAR CELL

Species difference in ANP32A underlies influenza A virus polymerase host restriction

(2016) Jason S. Long et al.   NATURE

Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor

(2016) Min-Suk Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase

(2016) Shuofeng Yuan et al.   Scientific Reports

The cap-binding site of influenza virus protein PB2 as a drug target

(2016) Chelsea Severin et al.   Acta Crystallographica Section D-Structural Biology

Inhibiting avian influenza virus shedding using a novel RNAi antiviral vector technology: proof of concept in an avian cell model

(2016) Lyndsey M. Linke et al.   AMB Express

Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5

(2016) Christopher Swale et al.   Scientific Reports

Cross-Protection of Influenza A Virus Infection by a DNA Aptamer Targeting the PA Endonuclease Domain

(2015) Shuofeng Yuan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An RNA Hybridization Assay for Screening Influenza A Virus Polymerase Inhibitors Using the Entire Ribonucleoprotein Complex

(2015) Franz-Ferdinand Roch et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Structural and computational study on inhibitory compounds for endonuclease activity of influenza virus polymerase

(2015) Satoshi Fudo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors

(2015) Michael J. Boyd et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The cytokine storm of severe influenza and development of immunomodulatory therapy

(2015) Qiang Liu et al.   Cellular & Molecular Immunology

Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza A virus H1N1

(2015) Meng-I. Lin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular Basis of mRNA Cap Recognition by Influenza B Polymerase PB2 Subunit

(2015) Lili Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Crystal Structure of the PB2 Cap-binding Domain of Influenza B Virus Reveals a Novel Cap Recognition Mechanism

(2015) Yong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigation of the salicylaldehyde thiosemicarbazone scaffold for inhibition of influenza virus PA endonuclease

(2015) Dominga Rogolino et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

RNA interference of influenza A virus replication by microRNA-adapted lentiviral loop short hairpin RNA

(2015) Fang Xu et al.   JOURNAL OF GENERAL VIROLOGY

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-O-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

(2015) Guangyi Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein–Basic Protein 1 (PA-PB1) Subunits

(2015) Serena Massari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effective Lethal Mutagenesis of Influenza Virus by Three Nucleoside Analogs

(2015) Matthew D. Pauly et al.   JOURNAL OF VIROLOGY

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus

(2015) Narin Hengrung et al.   NATURE

Advances in the development of influenza virus vaccines

(2015) Florian Krammer et al.   NATURE REVIEWS DRUG DISCOVERY

Sequencing the cap-snatching repertoire of H1N1 influenza provides insight into the mechanism of viral transcription initiation

(2015) David Koppstein et al.   NUCLEIC ACIDS RESEARCH

Influenza A virus preferentially snatches noncoding RNA caps

(2015) Weifeng Gu et al.   RNA

The RNA synthesis machinery of negative-stranded RNA viruses

(2015) Juan Ortín et al.   VIROLOGY

Influenza virus polymerase: Functions on host range, inhibition of cellular response to infection and pathogenicity

(2015) Ariel Rodriguez-Frandsen et al.   VIRUS RESEARCH

Rational design of protein–protein interaction inhibitors

(2015) Didier Rognan   MedChemComm

Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors

(2015) Nicolino Pala et al.   ACS Medicinal Chemistry Letters

Influenza virus–host interactomes as a basis for antiviral drug development

(2015) Tokiko Watanabe et al.   Current Opinion in Virology

A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein

(2015) Michinori Kakisaka et al.   PLoS Pathogens

pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA

(2015) Kenji Sugiyama et al.   eLife

Efficiency of Incorporation and Chain Termination Determines the Inhibition Potency of 2′-Modified Nucleotide Analogs against Hepatitis C Virus Polymerase

(2014) Amy Fung et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit

(2014) Randal A. Byrn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of a novel multiple kinase inhibitor with potent antiviral activity against influenza virus by reducing viral polymerase activity

(2014) Yutaka Sasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development

(2014) Tokiko Watanabe et al.   Cell Host & Microbe

Synthesis and Biological Evaluation of 2-oxo-pyrazine-3-carboxamide-yl Nucleoside Analogues and Their Epimers as Inhibitors of Influenza A Viruses

(2014) Jingjing Gao et al.   Chemical Biology & Drug Design

Influenza, a One Health paradigm—Novel therapeutic strategies to fight a zoonotic pathogen with pandemic potential

(2014) Stephan Ludwig et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Structure-based design of novel naproxen derivatives targeting monomeric nucleoprotein of Influenza A virus

(2014) Bogdan Tarus et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Optimization of Small-Molecule Inhibitors of Influenza Virus Polymerase: From Thiophene-3-Carboxamide to Polyamido Scaffolds

(2014) Susan Lepri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease

(2014) Hye Yeon Sagong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2

(2014) Michael P. Clark et al.   JOURNAL OF MEDICINAL CHEMISTRY

Magnesium-Dependent RNA Binding to the PA Endonuclease Domain of the Avian Influenza Polymerase

(2014) Shiyan Xiao et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Verdinexor, a Novel Selective Inhibitor of Nuclear Export, Reduces Influenza A Virus Replication In Vitro and In Vivo

(2014) O. Perwitasari et al.   JOURNAL OF VIROLOGY

Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options

(2014) Alimuddin Zumla et al.   LANCET INFECTIOUS DISEASES

Structural insight into cap-snatching and RNA synthesis by influenza polymerase

(2014) Stefan Reich et al.   NATURE

Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

At the centre: influenza A virus ribonucleoproteins

(2014) Amie J. Eisfeld et al.   NATURE REVIEWS MICROBIOLOGY

Influenza Vaccination of Pregnant Women and Protection of Their Infants

(2014) Shabir A. Madhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Rac1 Inhibitor NSC23766 Exerts Anti-Influenza Virus Properties by Affecting the Viral Polymerase Complex Activity

(2014) Rüdiger Dierkes et al.   PLoS One

Generation and characterization of influenza A viruses with altered polymerase fidelity

(2014) Peter P. H. Cheung et al.   Nature Communications

Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1

(2014) Spencer O. Moen et al.   Scientific Reports

Deep sequencing reveals the eight facets of the influenza A/HongKong/1/1968 (H3N2) virus cap-snatching process

(2014) Dorota Sikora et al.   Scientific Reports

Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors

(2013) Joseph D. Bauman et al.   ACS Chemical Biology

Structure-Based Discovery of the Novel Antiviral Properties of Naproxen against the Nucleoprotein of Influenza A Virus

(2013) Nathalie Lejal et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of Action of T-705 Ribosyl Triphosphate against Influenza Virus RNA Polymerase

(2013) Hidehiro Sangawa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and evaluation of a new phosphorylated ribavirin prodrug

(2013) Steven D. Dong et al.   ANTIVIRAL RESEARCH

The NF-kappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus

(2013) Emanuel Haasbach et al.   ANTIVIRAL RESEARCH

Combination of MEK inhibitors and oseltamivir leads to synergistic antiviral effects after influenza A virus infection in vitro

(2013) Emanuel Haasbach et al.   ANTIVIRAL RESEARCH

Influenza virus resistance to neuraminidase inhibitors

(2013) Mélanie Samson et al.   ANTIVIRAL RESEARCH

Favipiravir (T-705), a novel viral RNA polymerase inhibitor

(2013) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

Involvement of the N-terminal portion of influenza virus RNA polymerase subunit PB1 in nucleotide recognition

(2013) Nguyen Trong Binh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phenyl substituted 3-hydroxypyridin-2(1H)-ones: Inhibitors of influenza A endonuclease

(2013) Ajit K. Parhi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery and synthesis of novel benzofurazan derivatives as inhibitors of influenza A virus

(2013) Ulrich Kessler et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

High-throughput docking for the identification of new influenza A virus polymerase inhibitors targeting the PA–PB1 protein–protein interaction

(2013) Cristina Tintori et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The NF-κB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance

(2013) Christina Ehrhardt et al.   CELLULAR MICROBIOLOGY

A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication

(2013) Mi-Kyung Lee et al.   CHEMICAL COMMUNICATIONS

The Fight against the Influenza A Virus H1N1: Synthesis, Molecular Modeling, and Biological Evaluation of Benzofurazan Derivatives as Viral RNA Polymerase Inhibitors

(2013) Mafalda Pagano et al.   ChemMedChem

Synthesis and Biological Evaluation of Purine 2′-Fluoro-2′-deoxyriboside ProTides as Anti-influenza Virus Agents

(2013) Silvia Meneghesso et al.   ChemMedChem

Structural Investigation of Cycloheptathiophene-3-carboxamide Derivatives Targeting Influenza Virus Polymerase Assembly

(2013) Serena Massari et al.   JOURNAL OF MEDICINAL CHEMISTRY

New 7-Methylguanine Derivatives Targeting the Influenza Polymerase PB2 Cap-Binding Domain

(2013) Stéphane Pautus et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mutational Analysis of the Binding Pockets of the Diketo Acid Inhibitor L-742,001 in the Influenza Virus PA Endonuclease

(2013) A. Stevaert et al.   JOURNAL OF VIROLOGY

Nucleozin Targets Cytoplasmic Trafficking of Viral Ribonucleoprotein-Rab11 Complexes in Influenza A Virus Infection

(2013) M. J. Amorim et al.   JOURNAL OF VIROLOGY

The N-Terminal Domain of PA from Bat-Derived Influenza-Like Virus H17N10 Has Endonuclease Activity

(2013) B. Tefsen et al.   JOURNAL OF VIROLOGY

T-705 (Favipiravir) Induces Lethal Mutagenesis in Influenza A H1N1 Viruses In Vitro

(2013) T. Baranovich et al.   JOURNAL OF VIROLOGY

Metal-Chelating 2-Hydroxyphenyl Amide Pharmacophore for Inhibition of Influenza Virus Endonuclease

(2013) Mauro Carcelli et al.   MOLECULAR PHARMACEUTICS

Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage

(2013) Kausiki Datta et al.   NUCLEIC ACIDS RESEARCH

Anti-Influenza Activity of C60 Fullerene Derivatives

(2013) Masaki Shoji et al.   PLoS One

The Ambiguous Base-Pairing and High Substrate Efficiency of T-705 (Favipiravir) Ribofuranosyl 5′-Triphosphate towards Influenza A Virus Polymerase

(2013) Zhinan Jin et al.   PLoS One

Structural and energetic analysis of drug inhibition of the influenza A M2 proton channel

(2013) Ruo-Xu Gu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Influenza RNA-Dependent RNA Polymerase (RdRp) Inhibitors: Potential New Therapy for Influenza Treatment

(2013) Ahmed F. Abdel-Magid   ACS Medicinal Chemistry Letters

Computation-Guided Discovery of Influenza Endonuclease Inhibitors

(2013) Eric Chen et al.   ACS Medicinal Chemistry Letters

3-Hydroxyquinolin-2(1H)-ones As Inhibitors of Influenza A Endonuclease

(2013) Hye Yeon Sagong et al.   ACS Medicinal Chemistry Letters

A cell-based screening system for influenza A viral RNA transcription/replication inhibitors

(2013) Makoto Ozawa et al.   Scientific Reports

Identification of Influenza Endonuclease Inhibitors Using a Novel Fluorescence Polarization Assay

(2012) Brandi M. Baughman et al.   ACS Chemical Biology

Human Cytomegalovirus Inhibitor AL18 Also Possesses Activity against Influenza A and B Viruses

(2012) Giulia Muratore et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus

(2012) Silvia Meneghesso et al.   ANTIVIRAL RESEARCH

Viral enzymes containing magnesium: Metal binding as a successful strategy in drug design

(2012) Dominga Rogolino et al.   COORDINATION CHEMISTRY REVIEWS

A peptide derived from the C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly

(2012) Chunfeng Li et al.   FEBS Journal

Obatoclax, Saliphenylhalamide, and Gemcitabine Inhibit Influenza A Virus Infection

(2012) Oxana V. Denisova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and in Vitro Biological Evaluation of 1H-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein

(2012) Huimin Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

5'-Triphosphate-Short Interfering RNA: Potent Inhibition of Influenza A Virus Infection by Gene Silencing and RIG-I Activation

(2012) L. Lin et al.   JOURNAL OF VIROLOGY

Sequence in the Influenza A Virus Nucleoprotein Required for Viral Polymerase Binding and RNA Synthesis

(2012) J. K. Marklund et al.   JOURNAL OF VIROLOGY

Identification of a novel compound with antiviral activity against influenza A virus depending on PA subunit of viral RNA polymerase

(2012) Kazunori Yamada et al.   MICROBES AND INFECTION

Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase

(2012) G. Muratore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of Native Influenza Virion Ribonucleoproteins

(2012) R. Arranz et al.   SCIENCE

Organization of the Influenza Virus Replication Machinery

(2012) A. Moeller et al.   SCIENCE

Endonuclease substrate selectivity characterized with full-length PA of influenza A virus polymerase

(2012) Erin Noble et al.   VIROLOGY

A Novel Small Molecule Inhibitor of Influenza A Viruses that Targets Polymerase Function and Indirectly Induces Interferon

(2012) Mila Brum Ortigoza et al.   PLoS Pathogens

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

(2012) Rebecca M. DuBois et al.   PLoS Pathogens

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

(2012) Eva Kowalinski et al.   PLoS Pathogens

Identification of BPR3P0128 as an Inhibitor of Cap-Snatching Activities of Influenza Virus

(2011) John T.-A. Hsu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections

(2011) Yohichi Kumaki et al.   ANTIVIRAL RESEARCH

Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo

(2011) Karoline Droebner et al.   ANTIVIRAL RESEARCH

Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo

(2011) Ruth Pinto et al.   ANTIVIRAL RESEARCH

Role of the p21-activated kinases (PAKs) in influenza A virus replication

(2011) Philippe Noriel Q. Pascua et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure-based discovery of anti-influenza virus A compounds among medicines

(2011) Mayuko Fukuoka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Systematic review of influenza resistance to the neuraminidase inhibitors

(2011) Kristian Thorlund et al.   BMC INFECTIOUS DISEASES

Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase

(2011) Michael J. Sofia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recognition of Cap Structure by Influenza B Virus RNA Polymerase Is Less Dependent on the Methyl Residue than Recognition by Influenza A Virus Polymerase

(2011) C. Wakai et al.   JOURNAL OF VIROLOGY

Targeting of the Influenza A Virus Polymerase PB1-PB2 Interface Indicates Strain-Specific Assembly Differences

(2011) P. Reuther et al.   JOURNAL OF VIROLOGY

Identification of influenza virus inhibitors which disrupt of viral polymerase protein–protein interactions

(2011) Geoffrey Chase et al.   METHODS

Uncovering the global host cell requirements for influenza virus replication via RNAi screening

(2011) Silke Stertz et al.   MICROBES AND INFECTION

Anti-Influenza Activity of Marchantins, Macrocyclic Bisbibenzyls Contained in Liverworts

(2011) Yuma Iwai et al.   PLoS One

Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis

(2011) H.-H. Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors

(2011) Y.-F. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers

(2011) S. W. Gerritz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The influenza virus RNA synthesis machine

(2011) Patricia Resa-Infante et al.   RNA Biology

Structural Investigation of Rimantadine Inhibition of the AM2-BM2 Chimera Channel of Influenza Viruses

(2011) Rafal M. Pielak et al.   STRUCTURE

Identification of High-Affinity PB1-Derived Peptides with Enhanced Affinity to the PA Protein of Influenza A Virus Polymerase

(2010) Kerstin Wunderlich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Antiviral Activity of Favipiravir (T-705) against Drug-Resistant Influenza and 2009 A(H1N1) Viruses

(2010) K. Sleeman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays

(2010) Kyoji Hagiwara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel nucleosides as potent influenza viral inhibitors

(2010) Manohar Sharma Vedula et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anti-influenza activity of phenethylphenylphthalimide analogs derived from thalidomide

(2010) Yuma Iwai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

(−)-Carbodine: Enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu)

(2010) Jagadeeshwar R. Rao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cellular Networks Involved in the Influenza Virus Life Cycle

(2010) Tokiko Watanabe et al.   Cell Host & Microbe

Influenza A Virus Polymerase: Structural Insights into Replication and Host Adaptation Mechanisms

(2010) Stéphane Boivin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Analysis of the Influenza Virus H5N1 Nucleoprotein Tail Loop Reveals Amino Acids That Are Crucial for Oligomerization and Ribonucleoprotein Activities

(2010) W.-H. Chan et al.   JOURNAL OF VIROLOGY

Mutational and Metal Binding Analysis of the Endonuclease Domain of the Influenza Virus Polymerase PA Subunit

(2010) T. Crepin et al.   JOURNAL OF VIROLOGY

Therapy of experimental influenza virus infection with pyrrolidine dithiocarbamate

(2010) Nadine Wiesener et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Identification of influenza A nucleoprotein as an antiviral target

(2010) Richard Y Kao et al.   NATURE BIOTECHNOLOGY

Structures of influenza A proteins and insights into antiviral drug targets

(2010) Kalyan Das et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Emergence of a Multidrug-Resistant Pandemic Influenza A (H1N1) Virus

(2010) Erhard van der Vries et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity

(2010) C.-Y. Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

(2010) P. Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Base-pairing promotes leader selection to prime in vitro influenza genome transcription

(2010) Christina Geerts-Dimitriadou et al.   VIROLOGY

siRNA for Influenza Therapy

(2010) Sailen Barik   Viruses-Basel

T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections

(2009) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

Aryloxy Phosphoramidate Triesters: a Technology for Delivering Monophosphorylated Nucleosides and Sugars into Cells

(2009) Youcef Mehellou et al.   ChemMedChem

Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase

(2009) Kanako Sugiyama et al.   EMBO JOURNAL

Nucleoside Monophosphate Complex Structures of the Endonuclease Domain from the Influenza Virus Polymerase PA Subunit Reveal the Substrate Binding Site inside the Catalytic Center

(2009) C. Zhao et al.   JOURNAL OF VIROLOGY

Metalloproteomics, metalloproteomes, and the annotation of metalloproteins

(2009) Wolfgang Maret   Metallomics

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

(2009) Puwei Yuan et al.   NATURE

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

(2009) Alexandre Dias et al.   NATURE

Global Transmission of Oseltamivir-Resistant Influenza

(2009) Anne Moscona   NEW ENGLAND JOURNAL OF MEDICINE

Identification of a PA-Binding Peptide with Inhibitory Activity against Influenza A and B Virus Replication

(2009) Kerstin Wunderlich et al.   PLoS One

T-705 (favipiravir) activity against lethal H5N1 influenza A viruses

(2009) M. Kiso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and functional implications of the degradation of host RNA polymerase II in influenza virus infected cells

(2009) Frank T. Vreede et al.   VIROLOGY

Genetic trans-Complementation Establishes a New Model for Influenza Virus RNA Transcription and Replication

(2009) Núria Jorba et al.   PLoS Pathogens

Oseltamivir-Ribavirin Combination Therapy for Highly Pathogenic H5N1 Influenza Virus Infection in Mice

(2008) N. A. Ilyushina et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PA subunit of RNA polymerase as a promising target for anti-influenza virus agents

(2008) Misako Nakazawa et al.   ANTIVIRAL RESEARCH

Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design

(2008) Andy Ka-Leung Ng et al.   FASEB JOURNAL

Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

(2008) Xiaojing He et al.   NATURE

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

(2008) Eiji Obayashi et al.   NATURE

The structural basis for cap binding by influenza virus polymerase subunit PB2

(2008) Delphine Guilligay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hsp90 inhibitors reduce influenza virus replication in cell culture

(2008) Geoffrey Chase et al.   VIROLOGY