Synthesis of 1,2,3-triazolyl nucleoside analogues and their antiviral activity

Design, Synthesis, and Biological Evaluation of EdAP, a 4′-Ethynyl-2′-Deoxyadenosine 5′-Monophosphate Analog, as a Potent Influenza a Inhibitor

(2019) Toshifumi Takeuchi et al.   MOLECULES

Synthesis of novel 1,2,3-triazolyl nucleoside analogues bearing uracil, 6-methyluracil, 3,6-dimethyluracil, thymine, and quinazoline-2,4-dione moieties

(2019) Olga V. Andreeva et al.   TETRAHEDRON LETTERS

Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses

(2018) Jeong-Joong Yoon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold

(2018) Katherine L. Seley-Radtke et al.   ANTIVIRAL RESEARCH

Isosteric ribavirin analogues: Synthesis and antiviral activities

(2018) Nikolay I. Zhurilo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evidence for Novel Action at the Cell-Binding Site of Human Angiogenin Revealed by Heteronuclear NMR Spectroscopy, in silico and in vivo Studies

(2018) Demetra S. M. Chatzileontiadou et al.   ChemMedChem

The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold

(2018) Mary K. Yates et al.   ANTIVIRAL RESEARCH

Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase

(2017) Yousuke FURUTA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents

(2016) Cai Lin et al.   ANTIVIRAL RESEARCH

Approved Antiviral Drugs over the Past 50 Years

(2016) Erik De Clercq et al.   CLINICAL MICROBIOLOGY REVIEWS

Design, synthesis, anticancer, antimicrobial activities and molecular docking studies of theophylline containing acetylenes and theophylline containing 1,2,3-triazoles with variant nucleoside derivatives

(2016) Radhakrishnam Raju Ruddarraju et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues

(2016) Guangyi Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design

(2016) Annelies Stevaert et al.   MEDICINAL RESEARCH REVIEWS

5-(4-alkyl-1,2,3-triazol-1-yl)methyl derivatives of 2′-deoxyuridine as inhibitors of viral and bacterial growth

(2016) L. A. Alexandrova et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives

(2015) Krasimira T. Petrova et al.   CARBOHYDRATE RESEARCH

Effective Lethal Mutagenesis of Influenza Virus by Three Nucleoside Analogs

(2015) Matthew D. Pauly et al.   JOURNAL OF VIROLOGY

Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors

(2015) Nicolino Pala et al.   ACS Medicinal Chemistry Letters

The RNA-dependent RNA polymerase of the influenza A virus

(2014) Thomas M Stubbs et al.   Future Virology

Inhibition of Mycobacterium tuberculosis strains H37Rv and MDR MS-115 by a new set of C5 modified pyrimidine nucleosides

(2013) Eduard R. Shmalenyuk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation

(2012) Vanessa Parmenopoulou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Stereoselective Synthesis of α- and β-Glycofuranosyl Amides by Traceless Ligation of Glycofuranosyl Azides

(2012) Filippo Nisic et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of 2′-Deoxy-1′-homo-N-nucleosides with Anti-Influenza Activity by Catalytic Methyltrioxorhenium (MTO)/H2O2Oxyfunctionalization

(2012) Raffaele Saladino et al.   CHEMISTRY-A EUROPEAN JOURNAL

Viral enzymes containing magnesium: Metal binding as a successful strategy in drug design

(2012) Dominga Rogolino et al.   COORDINATION CHEMISTRY REVIEWS

Recent Researches in Triazole Compounds as Medicinal Drugs

(2012) C. -H. Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Click fleximers: a modular approach to purine base-expanded ribonucleoside analogues

(2012) André H. St. Amant et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Carbocyclic nucleoside analogues: classification, target enzymes, mechanisms of action and synthesis

(2012) E S Matyugina et al.   RUSSIAN CHEMICAL REVIEWS

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

(2012) Eva Kowalinski et al.   PLoS Pathogens

Combating enterovirus replication: State-of-the-art on antiviral research

(2011) Hendrik Jan Thibaut et al.   BIOCHEMICAL PHARMACOLOGY

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

A novel nucleoside analog, 1-β-d-ribofuranosyl-3-ethynyl-[1,2,4]triazole (ETAR), exhibits efficacy against a broad range of flaviviruses in vitro

(2010) Michael McDowell et al.   ANTIVIRAL RESEARCH

Novel nucleosides as potent influenza viral inhibitors

(2010) Manohar Sharma Vedula et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, and anticancer activities of novel perfluoroalkyltriazole-appended 2′-deoxyuridines

(2010) Sun Min Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2′-deoxyuridines and their antiviral evaluation

(2010) Aurélien Montagu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structures of influenza A proteins and insights into antiviral drug targets

(2010) Kalyan Das et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exploration of click reaction for the synthesis of modified nucleosides as chitin synthase inhibitors

(2009) Preeti M. Chaudhary et al.   BIOORGANIC & MEDICINAL CHEMISTRY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Another ten stories in antiviral drug discovery (part C): “Old” and “new” antivirals, strategies, and perspectives

(2009) Erik De Clercq   MEDICINAL RESEARCH REVIEWS

Emerging antiviral targets for influenza A virus

(2009) Robert M. Krug et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Synthesis of 1-β-d-ribofuranosyl-3-ethynyl-[1,2,4]triazole and its in vitro and in vivo efficacy against Hantavirus

(2008) Dong-Hoon Chung et al.   ANTIVIRAL RESEARCH

The discovery of antiviral agents: Ten different compounds, ten different stories

(2008) Erik De Clercq   MEDICINAL RESEARCH REVIEWS