Pursuing High-Resolution Structures of Nicotinic Acetylcholine Receptors: Lessons Learned from Five Decades

Structure and gating mechanism of the α7 nicotinic acetylcholine receptor

(2021) Colleen M. Noviello et al.   CELL

Tyrosine phosphorylation differentially fine-tunes ionotropic and metabotropic responses of human α7 nicotinic acetylcholine receptor

(2021) Juan Facundo Chrestia et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure and function at the lipid–protein interface of a pentameric ligand-gated ion channel

(2021) Pramod Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Measuring local-directional resolution and local anisotropy in cryo-EM maps

(2020) Jose Luis Vilas et al.   Nature Communications

The M4 Helix Is Involved in α7 nACh Receptor Function

(2020) Ana R.G.M. da Costa Couto et al.   ACS Chemical Neuroscience

Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins

(2020) Md. Mahfuzur Rahman et al.   NEURON

Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling

(2020) Roger L. Papke et al.   NEUROPHARMACOLOGY

Synthetic antibodies against BRIL as universal fiducial marks for single−particle cryoEM structure determination of membrane proteins

(2020) Somnath Mukherjee et al.   Nature Communications

The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking

(2020) Jolene Chang Rudell et al.   Frontiers in Molecular Neuroscience

Sequential purification and characterization of Torpedo californica nAChR-DC supplemented with CHS for high-resolution crystallization studies

(2020) Rafael Maldonado-Hernández et al.   ANALYTICAL BIOCHEMISTRY

Nicotinic Acetylcholine Receptor Accessory Subunits Determine the Activity Profile of Epibatidine Derivatives

(2020) Lu Wenchi Corrie et al.   MOLECULAR PHARMACOLOGY

Protein–lipid architecture of a cholinergic postsynaptic membrane

(2020) Nigel Unwin   IUCrJ

Single-particle cryo-EM at atomic resolution

(2020) Takanori Nakane et al.   NATURE

Effects of C-Terminal Carboxylation on α-Conotoxin LsIA Interactions with Human α7 Nicotinic Acetylcholine Receptor: Molecular Simulation Studies

(2019) Jierong Wen et al.   Marine Drugs

Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor

(2019) Anant Gharpure et al.   NEURON

In vivo Depiction of α7 Nicotinic Receptor Loss for Cognitive Decline in Alzheimer’s Disease

(2018) Kyoko Nakaizumi et al.   JOURNAL OF ALZHEIMERS DISEASE

Ionotropic and Metabotropic Mechanisms of Allosteric Modulation ofα7 Nicotinic Receptor Intracellular Calcium

(2018) Justin R. King et al.   MOLECULAR PHARMACOLOGY

Structural principles of distinct assemblies of the human α4β2 nicotinic receptor

(2018) Richard M. Walsh et al.   NATURE

Memtein: The fundamental unit of membrane-protein structure and function

(2018) Michael Overduin et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites

(2017) Duncan Laverty et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for GABAA receptor potentiation by neurosteroids

(2017) Paul S Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Efficient, ultra-high-affinity chromatography in a one-step purification of complex proteins

(2017) Marina N. Vassylyeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites

(2017) Duncan Laverty et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for GABAA receptor potentiation by neurosteroids

(2017) Paul S Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Model-based local density sharpening of cryo-EM maps

(2017) Arjen J Jakobi et al.   eLife

Assessment of the functionality and stability of detergent purified nAChR from Torpedo using lipidic matrixes and macroscopic electrophysiology

(2016) Luis F. Padilla-Morales et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

X-ray structure of the human α4β2 nicotinic receptor

(2016) Claudio L. Morales-Perez et al.   NATURE

Manipulation of Subunit Stoichiometry in Heteromeric Membrane Proteins

(2016) Claudio L. Morales-Perez et al.   STRUCTURE

Uncovering the lipidic basis for the preparation of functional nicotinic acetylcholine receptor detergent complexes for structural studies

(2016) Orestes Quesada et al.   Scientific Reports

Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors

(2016) Mariama Jaiteh et al.   PLoS One

Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2

(2016) Yaling Yin et al.   Scientific Reports

Ion channels gated by acetylcholine and serotonin: structures, biology and drug discovery

(2015) Zhong-shan Wu et al.   ACTA PHARMACOLOGICA SINICA

AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology

(2015) Andrea Cippitelli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of the Macrophage α7 Nicotinic Acetylcholine Receptor and Control of Inflammation

(2015) Carlos A. Báez-Pagán et al.   Journal of Neuroimmune Pharmacology

Nicotinic ACh receptors as therapeutic targets in CNS disorders

(2015) Kelly T. Dineley et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Nicotinic acetylcholine receptors in human genetic disease

(2014) Christian P. Schaaf   GENETICS IN MEDICINE

Heteroaromatic π-Stacking Energy Landscapes

(2014) Roland G. Huber et al.   Journal of Chemical Information and Modeling

X-ray structure of the mouse serotonin 5-HT3 receptor

(2014) Ghérici Hassaine et al.   NATURE

Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera

(2013) Sun Huang et al.   BIOCHEMICAL JOURNAL

Importance of the nicotinic acetylcholine receptor system in the prefrontal cortex

(2013) T.L. Wallace et al.   BIOCHEMICAL PHARMACOLOGY

Alterations in α4β2 nicotinic receptors in cognitive decline in Alzheimer’s aetiopathology

(2013) Hiroyuki Okada et al.   BRAIN

Determinants in the β and δ Subunit Cytoplasmic Loop Regulate Golgi Trafficking and Surface Expression of the Muscle Acetylcholine Receptor

(2013) Jolene Chang Rudell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and superorganization of acetylcholine receptor-rapsyn complexes

(2013) B. Zuber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α7 Nicotinic acetylcholine receptors and their role in cognition

(2012) Balázs Lendvai et al.   BRAIN RESEARCH BULLETIN

Structural basis of ligand recognition in 5-HT3 receptors

(2012) Divya Kesters et al.   EMBO REPORTS

Gating Movement of Acetylcholine Receptor Caught by Plunge-Freezing

(2012) Nigel Unwin et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease

(2011) Tanya L. Wallace et al.   BIOCHEMICAL PHARMACOLOGY

Brain regions mediating α3β4 nicotinic antagonist effects of 18-MC on nicotine self-administration

(2011) Stanley D. Glick et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of Lipid-Analog Detergent Solubilization on the Functionality and Lipidic Cubic Phase Mobility of the Torpedo californica Nicotinic Acetylcholine Receptor

(2011) Luis F. Padilla-Morales et al.   JOURNAL OF MEMBRANE BIOLOGY

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist

(2011) Shu-Xing Li et al.   NATURE NEUROSCIENCE

Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity

(2011) Fuxiang Bao et al.   NEUROBIOLOGY OF AGING

Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor

(2011) Carlos J. Baier et al.   Scientific Reports

A fluorescent derivatization method of proteins for the detection of low-level impurities by microchip capillary gel electrophoresis

(2010) Christian Wenz et al.   ELECTROPHORESIS

Decreased cerebral α4β2* nicotinic acetylcholine receptor availability in patients with mild cognitive impairment and Alzheimer’s disease assessed with positron emission tomography

(2010) Kai Kendziorra et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Phospholipase C Activity Affinity Purifies with theTorpedoNicotinic Acetylcholine Receptor

(2010) Jonathan M. Labriola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

123I-5-IA-85380 SPECT Imaging of Nicotinic Receptors in Alzheimer Disease and Mild Cognitive Impairment

(2009) E. M. Mitsis et al.   JOURNAL OF NUCLEAR MEDICINE

Nicotine binding to brain receptors requires a strong cation–π interaction

(2009) Xinan Xiu et al.   NATURE

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection

(2009) S. D. Buckingham et al.   PHARMACOLOGICAL REVIEWS

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

The relationship between nicotinic receptors and cognitive functioning in healthy aging: An in vivo positron emission tomography (PET) study with 2-[18F]fluoro-A-85380

(2009) J.R. Ellis et al.   SYNAPSE

Probing the Structure of the Affinity-Purified and Lipid-ReconstitutedTorpedoNicotinic Acetylcholine Receptor†

(2008) Ayman K. Hamouda et al.   BIOCHEMISTRY

Acetylcholine receptors in dementia and mild cognitive impairment

(2008) Osama Sabri et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Structural answers and persistent questions about how nicotinic receptors work

(2008) Gregg et al.   Frontiers in Bioscience-Landmark

Biophysical and Ion Channel Functional Characterization of the Torpedo californica Nicotinic Acetylcholine Receptor in Varying Detergent–Lipid Environments

(2008) Guillermo A. Asmar-Rovira et al.   JOURNAL OF MEMBRANE BIOLOGY

Assembly and trafficking of nicotinic acetylcholine receptors (Review)

(2008) Neil S. Millar et al.   MOLECULAR MEMBRANE BIOLOGY

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

Relationship between nicotinic receptors and cognitive function in early Alzheimer’s disease: A 2-[18F]fluoro-A-85380 PET study

(2008) J.R. Ellis et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The 5-HT3 receptor – the relationship between structure and function

(2008) Nicholas M. Barnes et al.   NEUROPHARMACOLOGY

Embedded cholesterol in the nicotinic acetylcholine receptor

(2008) G. Brannigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA