Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy

TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau

(2021) Peter E. A. Ash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

(2020) Jun Liu et al.   SCIENCE

Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease

(2020) Min Han et al.   Frontiers in Neuroscience

LRP1 is a master regulator of tau uptake and spread

(2020) Jennifer N. Rauch et al.   NATURE

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death

(2020) Mengyu Liu et al.   MOLECULAR NEUROBIOLOGY

The proline-rich domain promotes Tau liquid–liquid phase separation in cells

(2020) Xuemei Zhang et al.   JOURNAL OF CELL BIOLOGY

Tau Oligomers and Fibrils Exhibit Differential Patterns of Seeding and Association With RNA Binding Proteins

(2020) Lulu Jiang et al.   Frontiers in Neurology

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

(2020) Zhi Ruan et al.   BRAIN

Tau drives translational selectivity by interacting with ribosomal proteins

(2019) Shon A. Koren et al.   ACTA NEUROPATHOLOGICA

Decreased synthesis of ribosomal proteins in tauopathy revealed by non‐canonical amino acid labelling

(2019) Harrison Tudor Evans et al.   EMBO JOURNAL

The role of m6A RNA methylation in human cancer

(2019) Xiao-Yu Chen et al.   Molecular Cancer

m6A enhances the phase separation potential of mRNA

(2019) Ryan J. Ries et al.   NATURE

Regulation of signaling proteins in the brain by light

(2019) Raphael Lamprecht   PROGRESS IN NEUROBIOLOGY

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins

(2019) Xinzhu Wang et al.   Scientific Reports

Tau/DDX6 interaction increases microRNA activity

(2018) Alban Chauderlier et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The lamin code

(2018) Nadir M. Maraldi   BIOSYSTEMS

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

(2018) Ke Zhang et al.   CELL

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease

(2018) Isaac Bishof et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies

(2018) Wenyan Sun et al.   NATURE NEUROSCIENCE

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

(2018) Bahareh Eftekharzadeh et al.   NEURON

RNA m6A modification and its function in diseases

(2018) Jiyu Tong et al.   Frontiers of Medicine

RNA binding proteins co-localize with small tau inclusions in tauopathy

(2018) Brandon F. Maziuk et al.   Acta Neuropathologica Communications

TIA1 regulates the generation and response to toxic tau oligomers

(2018) Lulu Jiang et al.   ACTA NEUROPATHOLOGICA

Tau-induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila

(2018) Garrett L. Cornelison et al.   AGING CELL

Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology

(2018) Joana Margarida Silva et al.   CELL DEATH AND DIFFERENTIATION

Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

(2018) Erik C. B. Johnson et al.   Molecular Neurodegeneration

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

PRMT7 Interacts with ASS1 and Citrullinemia Mutations Disrupt the Interaction

(2017) Mamta Verma et al.   JOURNAL OF MOLECULAR BIOLOGY

RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein–RNA Interactome

(2017) A. Emilia Arguello et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

(2017) Daniel J. Apicco et al.   NATURE NEUROSCIENCE

N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis

(2017) Raghu R Edupuganti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation

(2017) William A. McEwan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis

(2017) Raghu R Edupuganti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Clusterin protects neurons against intracellular proteotoxicity

(2017) Jenna M. Gregory et al.   Acta Neuropathologica Communications

Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline

(2016) David J. Koss et al.   ACTA NEUROPATHOLOGICA

Lamin Dysfunction Mediates Neurodegeneration in Tauopathies

(2016) Bess Frost et al.   CURRENT BIOLOGY

Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis

(2016) S. Meier et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System

(2016) Fernando J. Martinez et al.   NEURON

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

(2016) Tara Vanderweyde et al.   Cell Reports

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy

(2015) Nicholas M. Kanaan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

(2015) Ke Zhang et al.   NATURE

Integrated molecular analysis of adult T cell leukemia/lymphoma

(2015) Keisuke Kataoka et al.   NATURE GENETICS

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Abnormal distribution of heterogeneous nuclear ribonucleoproteins in sporadic inclusion body myositis

(2014) Jack L. Pinkus et al.   NEUROMUSCULAR DISORDERS

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease

(2014) Yuan Zhou et al.   PLoS One

PICALM modulates autophagy activity and tau accumulation

(2014) Kevin Moreau et al.   Nature Communications

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

(2013) Casey Cook et al.   HUMAN MOLECULAR GENETICS

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations

(2013) Nam Chul Kim et al.   NEURON

Tau Oligomers as Potential Targets for Alzheimer’s Diagnosis and Novel Drugs

(2013) Leonardo Guzmán-Martinez et al.   Frontiers in Neurology

Analysis of the Tau-Associated Proteome Reveals That Exchange of Hsp70 for Hsp90 Is Involved in Tau Degradation

(2012) Andrea D. Thompson et al.   ACS Chemical Biology

Contrasting Pathology of the Stress Granule Proteins TIA-1 and G3BP in Tauopathies

(2012) T. Vanderweyde et al.   JOURNAL OF NEUROSCIENCE

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE

(2011) Ellen M. Wijsman et al.   PLoS Genetics

Automated analysis of neuronal morphology, synapse number and synaptic recruitment

(2010) Sabine K. Schmitz et al.   JOURNAL OF NEUROSCIENCE METHODS

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS