Tau Oligomers and Fibrils Exhibit Differential Patterns of Seeding and Association With RNA Binding Proteins

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

(2020) Tamta Arakhamia et al.   CELL

LRP1 is a master regulator of tau uptake and spread

(2020) Jennifer N. Rauch et al.   NATURE

SFPQ and Tau: critical factors contributing to rapid progression of Alzheimer’s disease

(2020) Neelam Younas et al.   ACTA NEUROPATHOLOGICA

Tau-mediated dysregulation of RNA: Evidence for a common molecular mechanism of toxicity in frontotemporal dementia and other tauopathies

(2020) Shon A. Koren et al.   NEUROBIOLOGY OF DISEASE

Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways

(2019) Kyle R. Christensen et al.   Acta Neuropathologica Communications

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity

(2019) Tuong-Vi Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress granules and neurodegeneration

(2019) Benjamin Wolozin et al.   NATURE REVIEWS NEUROSCIENCE

Near-atomic model of microtubule-tau interactions

(2018) Elizabeth H. Kellogg et al.   SCIENCE

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

The involvement of tau in nucleolar transcription and the stress response

(2018) Mahmoud B. Maina et al.   Acta Neuropathologica Communications

RNA binding proteins co-localize with small tau inclusions in tauopathy

(2018) Brandon F. Maziuk et al.   Acta Neuropathologica Communications

TIA1 regulates the generation and response to toxic tau oligomers

(2018) Lulu Jiang et al.   ACTA NEUROPATHOLOGICA

Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology

(2018) Joana Margarida Silva et al.   CELL DEATH AND DIFFERENTIATION

A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

(2018) Hongjun Fu et al.   NATURE NEUROSCIENCE

Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer’s disease

(2018) Urmi Sengupta et al.   Acta Neuropathologica Communications

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

(2017) Daniel J. Apicco et al.   NATURE NEUROSCIENCE

The role of ubiquitin proteasomal system and autophagy-lysosome pathway in Alzheimer’s disease

(2017) Yuan Zhang et al.   REVIEWS IN THE NEUROSCIENCES

p53 oligomerization status modulates cell fate decisions between growth, arrest and apoptosis

(2016) Nicholas W. Fischer et al.   CELL CYCLE

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis

(2016) S. Meier et al.   JOURNAL OF NEUROSCIENCE

Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau

(2016) S. J. Jackson et al.   JOURNAL OF NEUROSCIENCE

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

(2016) Tara Vanderweyde et al.   Cell Reports

Microglial Aβ Receptors in Alzheimer’s Disease

(2014) Yang Yu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

(2014) Hans Zempel et al.   TRENDS IN NEUROSCIENCES

PICALM modulates autophagy activity and tau accumulation

(2014) Kevin Moreau et al.   Nature Communications

A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis

(2013) Xiao-Jian Sun et al.   NATURE

Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathy

(2012) Johanna L. Crimins et al.   ACTA NEUROPATHOLOGICA

Apolipoprotein E3 (ApoE3) but Not ApoE4 Protects against Synaptic Loss through Increased Expression of Protein Kinase Cϵ

(2012) Abhik Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contrasting Pathology of the Stress Granule Proteins TIA-1 and G3BP in Tauopathies

(2012) T. Vanderweyde et al.   JOURNAL OF NEUROSCIENCE

Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs

(2009) A.B. Rocher et al.   EXPERIMENTAL NEUROLOGY