An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks

ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells

(2021) Yusuke Shiromoto et al.   Nature Communications

Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development

(2020) Sze Jing Tang et al.   Nature Communications

Genomic Identification of RNA Editing Through Integrating Omics Datasets and the Clinical Relevance in Hepatocellular Carcinoma

(2020) Juan Chen et al.   Frontiers in Oncology

ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity

(2020) Julia Ramírez-Moya et al.   ONCOGENE

Splicing and cancer: Challenges and opportunities

(2019) Patricia P. Coltri et al.   Wiley Interdisciplinary Reviews-RNA

Adenosine deaminase acting on RNA (ADAR1), a suppressor of double-stranded RNA–triggered innate immune responses

(2019) Charles E. Samuel   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness

(2019) Julia Ramírez-Moya et al.   ONCOGENE

ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation

(2019) Xue Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ADAR1: “Editor-in-Chief” of Cytoplasmic Innate Immunity

(2019) Mart M. Lamers et al.   Frontiers in Immunology

Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer

(2019) Victor Quereda et al.   CANCER CELL

Hypoxia-Induced TPM2 Methylation is Associated with Chemoresistance and Poor Prognosis in Breast Cancer

(2018) Jinfeng Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

CDK13 RNA Over-Editing Mediated by ADAR1 Associates with Poor Prognosis of Hepatocellular Carcinoma Patients

(2018) Xiuqing Dong et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

RNA editing in nascent RNA affects pre-mRNA splicing

(2018) Yun-Hua Esther Hsiao et al.   GENOME RESEARCH

MicroRNA-146b promotes PI3K/AKT pathway hyperactivation and thyroid cancer progression by targeting PTEN

(2018) Julia Ramírez-Moya et al.   ONCOGENE

ADARs and editing: The role of A-to-I RNA modification in cancer progression

(2018) Kajsa Fritzell et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

(2018) Hugh S. Gannon et al.   Nature Communications

Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13

(2018) Mei Zeng et al.   eLife

ADAR1 Editing and its Role in Cancer

(2018) Li-Di Xu et al.   Genes

Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers

(2017) Yumeng Wang et al.   GENOME RESEARCH

Trends in Thyroid Cancer Incidence and Mortality in the United States, 1974-2013

(2017) Hyeyeun Lim et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

SR Proteins: Binders, Regulators, and Connectors of RNA

(2017) Sunjoo Jeong   MOLECULES AND CELLS

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Atropos: specific, sensitive, and speedy trimming of sequencing reads

(2017) John P. Didion et al.   PeerJ

Thyroid Cancer Epidemiology in Iran: a Time Trend Study

(2016) Ali Safavi et al.   Asian Pacific Journal of Cancer Prevention

Increasing incidence of thyroid cancer in the Nordic countries with main focus on Swedish data

(2016) Michael Carlberg et al.   BMC CANCER

The hnRNP family: insights into their role in health and disease

(2016) Thomas Geuens et al.   HUMAN GENETICS

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

(2016) Tinghu Zhang et al.   Nature Chemical Biology

Epigenetic silencing of TPM2 contributes to colorectal cancer progression upon RhoA activation

(2016) Ji Cui et al.   TUMOR BIOLOGY

Structural and Functional Analysis of the Cdk13/Cyclin K Complex

(2016) Ann Katrin Greifenberg et al.   Cell Reports

Characterization of human disease phenotypes associated with mutations inTREX1,RNASEH2A,RNASEH2B,RNASEH2C,SAMHD1,ADAR, andIFIH1

(2015) Yanick J. Crow et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Autoimmune thyroid disorders

(2015) Alessandro Antonelli et al.   AUTOIMMUNITY REVIEWS

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

(2015) Leng Han et al.   CANCER CELL

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

A-to-I editing of coding and non-coding RNAs by ADARs

(2015) Kazuko Nishikura   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors

(2015) Nurit Paz-Yaacov et al.   Cell Reports

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome

(2015) Debora Fumagalli et al.   Cell Reports

RNA Editome Imbalance in Hepatocellular Carcinoma

(2014) L. Qi et al.   CANCER RESEARCH

A biochemical landscape of A-to-I RNA editing in the human brain transcriptome

(2014) M. Sakurai et al.   GENOME RESEARCH

RNA editing inRHOQpromotes invasion potential in colorectal cancer

(2014) Sae-Won Han et al.   JOURNAL OF EXPERIMENTAL MEDICINE

rMATS: Robust and flexible detection of differential alternative splicing from replicate RNA-Seq data

(2014) Shihao Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma

(2013) Y.-R. Qin et al.   CANCER RESEARCH

Regulation of splicing by SR proteins and SR protein-specific kinases

(2013) Zhihong Zhou et al.   CHROMOSOMA

p120-catenin in cancer - mechanisms, models and opportunities for intervention

(2013) R. C. J. Schackmann et al.   JOURNAL OF CELL SCIENCE

Global regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR)

(2013) O. Solomon et al.   RNA

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

Frequent Amplification of CENPF, GMNN and CDK13 Genes in Hepatocellular Carcinomas

(2012) Hye-Eun Kim et al.   PLoS One

ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia

(2012) Q. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular genetics and diagnosis of thyroid cancer

(2011) Yuri E. Nikiforov et al.   Nature Reviews Endocrinology

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Nuclear Speckles

(2010) D. L. Spector et al.   Cold Spring Harbor Perspectives in Biology

Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs

(2009) S. Kosugi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Functions of Natural ADAM-15 Cytoplasmic Domain Variants in Human Mammary Carcinoma

(2008) J. L. Zhong et al.   MOLECULAR CANCER RESEARCH

Molecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosis

(2007) Marina N Nikiforova et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS