An update of the molecular mechanisms underlying doxorubicin plus trastuzumab induced cardiotoxicity
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Title
An update of the molecular mechanisms underlying doxorubicin plus trastuzumab induced cardiotoxicity
Authors
Keywords
Cardiomyocytes, Endothelial cells, Oxidative stress, HER2 signaling, Neuregulin-1
Journal
LIFE SCIENCES
Volume 280, Issue -, Pages 119760
Publisher
Elsevier BV
Online
2021-06-21
DOI
10.1016/j.lfs.2021.119760
References
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Note: Only part of the references are listed.- Unique Phenotypes of Heart Resident Type 2 Innate Lymphoid Cells
- (2020) Yafei Deng et al. Frontiers in Immunology
- The role of endothelial autocrine NRG1/ERBB4 signaling in cardiac remodeling
- (2020) Lindsey Dugaucquier et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Drug uptake-based chemoresistance in breast cancer treatment
- (2020) Helena Muley et al. BIOCHEMICAL PHARMACOLOGY
- Irbesartan suppresses cardiac toxicity induced by doxorubicin via regulating the p38-MAPK/NF-κB and TGF-β1 pathways
- (2019) Nermin T. El-Said et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Management of Cardiovascular Disease in Women With Breast Cancer
- (2019) Rachel Barish et al. CIRCULATION
- Twist and Turn—Topoisomerase Functions in Mitochondrial DNA Maintenance
- (2019) Steffi Goffart et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- HER2+ breast cancer treatment and cardiotoxicity: monitoring and management
- (2019) Guy Jerusalem et al. BREAST CANCER RESEARCH AND TREATMENT
- Cancer treatment and survivorship statistics, 2019
- (2019) Kimberly D. Miller et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Corrigendum to “Chemotherapeutic Drugs and Mitochondrial Dysfunction: Focus on Doxorubicin, Trastuzumab, and Sunitinib”
- (2019) Stefania Gorini et al. Oxidative Medicine and Cellular Longevity
- Mesenchymal Stem Cell Therapy for Doxorubicin-Induced Cardiomyopathy: Potential Mechanisms, Governing Factors, and Implications of the Heart Stem Cell Debate
- (2019) Abdelrahman Ibrahim Abushouk et al. Frontiers in Pharmacology
- Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways
- (2019) Masatoshi Narikawa et al. PLoS One
- The Role of Topoisomerase IIβ in the Mechanisms of Action of the Doxorubicin Cardioprotective Agent Dexrazoxane
- (2019) Brian B. Hasinoff et al. Cardiovascular Toxicology
- Mitophagy, Mitochondrial Dynamics, and Homeostasis in Cardiovascular Aging
- (2019) Ne N. Wu et al. Oxidative Medicine and Cellular Longevity
- Early morphological changes in cardiac mitochondria after subcutaneous administration of trastuzumab in rabbits: possible prevention with oral selenium supplementation
- (2019) Heather S. Laird-Fick et al. CARDIOVASCULAR PATHOLOGY
- Molecular mechanism of doxorubicin-induced cardiomyopathy – An update
- (2018) Kaviyarasi Renu et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Characterizations of mitochondrial uncoupling induced by chemical mitochondrial uncouplers in cardiomyocytes
- (2018) Jin-Lai Gao et al. FREE RADICAL BIOLOGY AND MEDICINE
- Drug transporters and anthracycline-induced cardiotoxicity
- (2018) Kevin M Huang et al. PHARMACOGENOMICS
- Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway
- (2018) Jian Yin et al. TOXICOLOGY IN VITRO
- Doxorubicin-induced cardiotoxicity is suppressed by estrous-staged treatment and exogenous 17β-estradiol in female tumor-bearing spontaneously hypertensive rats
- (2018) Kaytee L. Pokrzywinski et al. Biology of Sex Differences
- Antineoplastic Drug-Induced Cardiotoxicity: A Redox Perspective
- (2018) Gilda Varricchi et al. Frontiers in Physiology
- Doxorubicin-Induced Myocardial Fibrosis Involves the Neurokinin-1 Receptor and Direct Effects on Cardiac Fibroblasts
- (2018) Scott P. Levick et al. Heart Lung and Circulation
- Sugar or fat: The metabolic choice of the trained heart
- (2018) Rita Ferreira et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Doxorubicin-induced cardiotoxicity involves IFNγ-mediated metabolic reprogramming in cardiomyocytes
- (2018) Chen Ni et al. JOURNAL OF PATHOLOGY
- Combination of chemotherapy and physical plasma elicits melanoma cell death via upregulation of SLC22A16
- (2018) Sanjeev Kumar Sagwal et al. Cell Death & Disease
- Updates in Anthracycline-Mediated Cardiotoxicity
- (2018) Canan G. Nebigil et al. Frontiers in Pharmacology
- Evolution of Cancer Pharmacological Treatments at the Turn of the Third Millennium
- (2018) Luca Falzone et al. Frontiers in Pharmacology
- Polyphenols, autophagy and doxorubicin-induced cardiotoxicity
- (2017) S. Shabalala et al. LIFE SCIENCES
- Long-Term and Latent Side Effects of Specific Cancer Types
- (2017) Nana Gegechkori et al. MEDICAL CLINICS OF NORTH AMERICA
- Cardiac Nonmyocyte Cell Functions and Crosstalks in Response to Cardiotoxic Drugs
- (2017) Jessica Gambardella et al. Oxidative Medicine and Cellular Longevity
- Type IIB DNA topoisomerase is downregulated by trastuzumab and doxorubicin to synergize cardiotoxicity
- (2017) Jiangsong Jiang et al. Oncotarget
- Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity
- (2017) Navid Koleini et al. Oncotarget
- IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice
- (2017) Yusuke Shintani et al. Scientific Reports
- Cardiotoxicity From Human Epidermal Growth Factor Receptor‐2 (HER2) Targeted Therapies
- (2017) Roberta Florido et al. Journal of the American Heart Association
- Antiarrhythmic effect of growth factor-supplemented cardiac progenitor cells in chronic infarcted heart
- (2016) Monia Savi et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Role of endothelin-1 in mediating changes in cardiac sympathetic nerve activity in heart failure
- (2016) Yonis Abukar et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Trastuzumab in the Treatment of Breast Cancer
- (2016) Sofia Maximiano et al. BIODRUGS
- Trastuzumab cardiotoxicity: from clinical trials to experimental studies
- (2016) Balazs T Nemeth et al. BRITISH JOURNAL OF PHARMACOLOGY
- Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome AcidificationCLINICAL PERSPECTIVE
- (2016) Dan L. Li et al. CIRCULATION
- Doxorubicin-Mediated Toxic Effects Are Mediated Via NO/eNOS in a Novel 3D in Vitro Model of the Human Heart
- (2016) Liudmila Polonchuk et al. FREE RADICAL BIOLOGY AND MEDICINE
- Resveratrol-induced autophagy promotes survival and attenuates doxorubicin-induced cardiotoxicity
- (2016) Jun Gu et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Antineoplastic-related cardiotoxicity, morphofunctional aspects in a murine model: contribution of the new tool 2D-speckle tracking
- (2016) Carmela Coppola et al. OncoTargets and Therapy
- Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity
- (2016) J Wu et al. Cell Death & Disease
- Astragalus polysaccharide restores autophagic flux and improves cardiomyocyte function in doxorubicin-induced cardiotoxicity
- (2016) Yuan Cao et al. Oncotarget
- NLRP3 Deficiency Reduces Macrophage Interleukin-10 Production and Enhances the Susceptibility to Doxorubicin-induced Cardiotoxicity
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- (2016) Gennaro Riccio et al. Human Vaccines & Immunotherapeutics
- Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability
- (2016) Emma L. Wilkinson et al. Biology Open
- Deficiency in Cardiolipin Reduces Doxorubicin-Induced Oxidative Stress and Mitochondrial Damage in Human B-Lymphocytes
- (2016) Baikuntha Aryal et al. PLoS One
- ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity
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- The influence of steroid receptor status on the cardiotoxicity risk in HER2-positive breast cancer patients receiving trastuzumab
- (2015) Joanna Huszno et al. Archives of Medical Science
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- NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice
- (2015) Heike Langbein et al. EUROPEAN HEART JOURNAL
- SIRT1 activation rescues doxorubicin-induced loss of functional competence of human cardiac progenitor cells
- (2015) Antonella De Angelis et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Doxorubicin Impairs the Insulin-Like Growth Factor-1 System and Causes Insulin-Like Growth Factor-1 Resistance in Cardiomyocytes
- (2015) Patrizia Fabbi et al. PLoS One
- Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis
- (2015) Rui-Ming Liu et al. Redox Biology
- Ghrelin inhibits doxorubicin cardiotoxicity by inhibiting excessive autophagy through AMPK and p38-MAPK
- (2014) Xue Wang et al. BIOCHEMICAL PHARMACOLOGY
- Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: role of ETAand ETBreceptors
- (2014) A Sánchez et al. BRITISH JOURNAL OF PHARMACOLOGY
- Autophagy—a key player in cellular and body metabolism
- (2014) Kook Hwan Kim et al. Nature Reviews Endocrinology
- Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling
- (2014) Rimpy Dhingra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Doxorubicin induces senescence and impairs function of human cardiac progenitor cells
- (2013) Elena Piegari et al. BASIC RESEARCH IN CARDIOLOGY
- The role of antioxidants in the era of cardio-oncology
- (2013) Duncan T. Vincent et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Anthracyclines and Heart Failure
- (2013) Douglas B. Sawyer NEW ENGLAND JOURNAL OF MEDICINE
- Macrophage Migration Inhibitory Factor Deficiency Augments Doxorubicin‐Induced Cardiomyopathy
- (2013) Xihui Xu et al. Journal of the American Heart Association
- Gastric cancer and trastuzumab: first biologic therapy in gastric cancer
- (2013) Krishna S. Gunturu et al. Therapeutic Advances in Medical Oncology
- Chronic cardiotoxicity of doxorubicin involves activation of myocardial and circulating matrix metalloproteinases in rats
- (2012) Monika Ivanová et al. ACTA PHARMACOLOGICA SINICA
- Angiotensin II and Oxidative Stress in the Failing Heart
- (2012) Daniela Zablocki et al. ANTIOXIDANTS & REDOX SIGNALING
- Vascular endothelin receptor type B: Structure, function and dysregulation in vascular disease
- (2012) Marc Q. Mazzuca et al. BIOCHEMICAL PHARMACOLOGY
- Vitamin E and telmisartan attenuates doxorubicin induced cardiac injury in rat through down regulation of inflammatory response
- (2012) Najah Hadi et al. BMC Cardiovascular Disorders
- Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes
- (2012) Tomonori Kawaguchi et al. CARDIOVASCULAR RESEARCH
- Inhibition of AMP-activated Protein Kinase α (AMPKα) by Doxorubicin Accentuates Genotoxic Stress and Cell Death in Mouse Embryonic Fibroblasts and Cardiomyocytes
- (2012) Shaobin Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies
- (2012) Yanti Octavia et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Functional Impairment of Human Resident Cardiac Stem Cells by the Cardiotoxic Antineoplastic Agent Trastuzumab
- (2012) Andreas S. Barth et al. Stem Cells Translational Medicine
- Trastuzumab: Updated Mechanisms of Action and Resistance in Breast Cancer
- (2012) Thuy Vu et al. Frontiers in Oncology
- TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation
- (2011) D V Krysko et al. CELL DEATH AND DIFFERENTIATION
- Catechin protects against oxidative stress and inflammatory-mediated cardiotoxicity in adriamycin-treated rats
- (2011) Tarek A. Abd El-Aziz et al. CLINICAL AND EXPERIMENTAL MEDICINE
- Trastuzumab Adjuvant Chemotherapy and Cardiotoxicity in Real-World Women With Breast Cancer
- (2011) Luigi Tarantini et al. JOURNAL OF CARDIAC FAILURE
- Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion
- (2010) Kerstin Boengler et al. BASIC RESEARCH IN CARDIOLOGY
- Hepatocyte growth factor/Met gene transfer in cardiac stem cells—potential for cardiac repair
- (2010) Rosalinda Madonna et al. BASIC RESEARCH IN CARDIOLOGY
- Mechanism of anthracycline-mediated down-regulation of GATA4 in the heart
- (2010) Ah-Mee Park et al. CARDIOVASCULAR RESEARCH
- How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?
- (2010) Yohannes Mebratu et al. CELL CYCLE
- Smad3 Signaling Critically Regulates Fibroblast Phenotype and Function in Healing Myocardial Infarction
- (2010) Marcin Dobaczewski et al. CIRCULATION RESEARCH
- PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
- (2010) Noriyuki Matsuda et al. JOURNAL OF CELL BIOLOGY
- Glutathione depletion upregulates P-glycoprotein expression at the blood-brain barrier in rats
- (2010) Jing Wu et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Drug Resistance in Breast Cancer Cells: Biophysical Characterization of and Doxorubicin Interactions with Membrane Lipids
- (2010) Chiranjeevi Peetla et al. MOLECULAR PHARMACEUTICS
- Doxorubicin selectively suppresses mRNA expression and production of endothelin-1 in endothelial cells
- (2010) Katalin Keltai et al. VASCULAR PHARMACOLOGY
- PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
- (2010) Derek P. Narendra et al. PLOS BIOLOGY
- Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins
- (2009) Yun Bian et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro
- (2009) Partha Mukhopadhyay et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats
- (2009) Anne M. Deschamps et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Doxorubicin Cardiomyopathy
- (2009) Kanu Chatterjee et al. CARDIOLOGY
- Anthracycline Cardiomyopathy Is Mediated by Depletion of the Cardiac Stem Cell Pool and Is Rescued by Restoration of Progenitor Cell Function
- (2009) Antonella De Angelis et al. CIRCULATION
- Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue
- (2009) Shigeki Miyamoto et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Cardiovascular Complications of Cancer Therapy
- (2009) Edward T.H. Yeh et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Mitochondrial DNA is a direct target of anti-cancer anthracycline drugs
- (2008) Neil Ashley et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Interaction of anthracyclines with iron responsive element mRNAs
- (2008) Joshua C. Canzoneri et al. NUCLEIC ACIDS RESEARCH
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