Article
Immunology
Yaritza Inostroza-Nieves, Alicia Rivera, Jose R. Romero
Summary: A study found that Major Histocompatibility Complex (MHC) molecules play a role in Sickle Cell Disease (SCD) pathophysiology. Endothelial cells express MHC molecules after exposure to cytokines. SCD is characterized by vascular endothelial cell activation, oxidative stress, sickle cell adhesion, and excess levels of endothelin-1 (ET-1). The study suggests that ET-1 is a novel regulator of MHC class II molecules and ET-1 receptor blockade may be a promising therapeutic approach for regulating immune and vascular responses in SCD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Jordana Kron, Thomas Crawford, Virginia Mihalick, Frank Bogun, Jennifer H. Jordan, Todd Koelling, Huzaefah Syed, Aamer Syed, Thomas Iden, Kelly Polly, Emily Federmann, Kirsta Bray, Sangeeta Lathkar-Pradhan, Shilpa Jasti, Lynda Rosenfeld, David Birnie, Melissa Smallfield, Le Kang, Alpha Berry Fowler, Amy Ladd, Kenneth Ellenbogen, Benjamin Van Tassell, W. Gregory Hundley, Antonio Abbate
Summary: Cardiac sarcoidosis is a rare disease that can lead to life-threatening complications, and this trial aims to investigate the effectiveness of IL-1 blockade with anakinra in combating systemic and cardiac inflammation in patients with this condition.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Yohei Ueno, Teruhiko Imamura, Akira Oshima, Hiroshi Onoda, Ryuichi Ushijima, Mitsuo Sobajima, Nobuyuki Fukuda, Hiroshi Ueno, Koichiro Kinugawa
Summary: In this study, respiratory stability time (RST) significantly improved following TAVR, while a lower RST was associated with an increased risk of heart failure readmission.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Hiddo J. L. Heerspink, Arihiro Kiyosue, David C. Wheeler, Min Lin, Emma Wijkmark, Glenn Carlson, Anne-Kristina Mercier, Magnus Astrand, Sebastian Ueckert, Peter J. Greasley, Phil Ambery
Summary: This study evaluated the efficacy and safety of the ERA zibotentan combined with the SGLT2 inhibitor dapagliflozin in reducing albuminuria and protecting kidney function.
Article
Endocrinology & Metabolism
Zhiyuan Guan, Wanqiong Yuan, Jialin Jia, Chenggui Zhang, Junxiong Zhu, Jie Huang, Wang Zhang, Dongwei Fan, Huijie Leng, Zijian Li, Yingsheng Xu, Chunli Song
Summary: The present study supports the relationship between heart failure and bone loss, and suggests that excessive activation of sympathetic nerves contributes to this pathophysiological process. It provides a potential pathological mechanism of heart failure-related osteoporosis and new perspectives for developing strategies to address bone loss associated with heart failure.
Article
Medicine, Research & Experimental
Petr Kala, Zdenka Vanourkova, Petra Skaroupkova, Elzbieta Kompanowska-Jezierska, Janusz Sadowski, Agnieszka Walkowska, Josef Veselka, Milos Taborsky, Hana Maxova, Ivana Vaneckova, Ludek Cervenka
Summary: The aim of this study was to examine the additional beneficial effects of adding endothelin type A (ETA) receptor antagonist to angiotensin-converting enzyme inhibitor (ACEi) in experimental rats with congestive heart failure (CHF) and chronic kidney disease (CKD). The results showed that ETA receptor antagonist, ACEi alone, and the combination of both improved survival rate and provided renoprotective effects. However, the difference between the combination treatment and either single treatment was not significant.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Physiology
Jacqueline K. Limberg, Sarah E. Baker, Elizabeth P. Ott, Dain W. Jacob, Zachariah M. Scruggs, Jennifer L. Harper, Camila M. Manrique-Acevedo
Summary: This study found that even with the use of ET receptor antagonists, the sympathetic nerve activity and blood pressure response of men cannot be reduced when exposed to low oxygen conditions.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Jiandong Zhang, Paul C. Simpson, Brian C. Jensen
Summary: Alpha 1-adrenergic receptors play essential roles in cardiovascular physiology, and activation of cardiac alpha 1-ARs may have cardioprotective effects.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Neurosciences
Qixing Hu, Guilin Li
Summary: Diabetic cardiac autonomic neuropathy is a serious complication of diabetes that affects the sympathetic and parasympathetic nerves. Purinergic receptors play a crucial role in this process. A study summarized in this paper explores the abnormal changes in sympathetic nerve function in diabetes and highlights the significance of targeting purinergic receptors for the treatment of diabetic autonomic neuropathy.
Article
Cardiac & Cardiovascular Systems
Su Ern Yeoh, Kieran F. Docherty, Ross T. Campbell, Pardeep S. Jhund, Ann Hammarstedt, Hiddo J. L. Heerspink, Petr Jarolim, Lars Kober, Mikhail N. Kosiborod, Felipe A. Martinez, Piotr Ponikowski, Scott D. Solomon, Mikaela Sjoestrand, Olof Bengtsson, Peter J. Greasley, Naveed Sattar, Paul Welsh, Marc S. Sabatine, David A. Morrow, John J. V. McMurray
Summary: ET-1 is implicated in heart failure and renal disease. This study investigated the relationship between ET-1 and clinical outcomes, as well as the efficacy of dapagliflozin in heart failure patients. Higher baseline ET-1 was associated with worse outcomes and decline in kidney function, while dapagliflozin showed consistent benefits across different ET-1 levels and reduced serum ET-1 concentration.
Article
Medicine, General & Internal
Takahiro Doi, Tomoaki Nakata, Takahiro Noto, Tomohiro Mita, Daigo Nagahara, Satoshi Yuda, Akiyoshi Hashimoto
Summary: This study analyzed the relationship between left ventricular mechanical dyssynchrony, left ventricular hypertrophy, cardiac sympathetic innervation, and lethal cardiac events in heart failure patients. The results showed that patients with greater phase SD, greater LVMI, and lower MIBG HMR were more likely to experience lethal cardiac events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Yu-Long Li
Summary: Heart failure is a significant global public health issue, with coronary heart disease-induced HF being the most common type, accounting for over 50%. Cardiac sympathetic overactivation is a major cause of mortality in HF patients and involves complex regulatory mechanisms at multiple levels of the nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Amanda G. Rodrigues, Allan R. K. Sales, Diego Faria, Silvia M. R. Fonseca, Marina M. K. Bond, Camila P. Jordao, Francis R. de Souza, Cristina S. Bittar, Marilia H. H. Dos Santos, Adriana O. Sarmento, Marcelo V. Negrao, Ludhmila A. Hajjar, Carlos E. Negrao, Roberto Kalil Filho
Summary: This study found that patients who develop heart failure due to anthracycline-based chemotherapy have increased sympathetic nerve activity and reduced exercise capacity. These physiological changes are similar to those observed in patients with heart failure caused by other etiologies.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Richard K. Cheng, Alexi Vasbinder, Wayne C. Levy, Parag Goyal, Jan M. Griffin, Douglas J. Leedy, Mathew S. Maurer
Summary: This study found no association between the use of neurohormonal blockade and survival in patients with transthyretin cardiac amyloidosis. Discontinuing beta-blockers may be associated with improved survival in the overall cohort.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, Research & Experimental
Evangelos Triantafyllou, Cathrin L. C. Gudd, Marie-Anne Mawhin, Hannah C. Husbyn, Francesca M. Trovato, Matthew K. Siggins, Thomas O'Connor, Hiromi Kudo, Sujit K. Mukherjee, Julia A. Wendon, Christine Bernsmeier, Robert D. Goldin, Marina Botto, Wafa Khamri, Mark J. W. McPhail, Lucia A. Possamai, Kevin J. Woollard, Charalambos G. Antoniades, Mark R. Thursz
Summary: The PD-1/PD-L1 pathway regulates KC and monocyte antimicrobial responses after acute liver injury, suppressing immune response and increasing susceptibility to infections.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Letter
Cardiac & Cardiovascular Systems
Davide Martelli, Alessandro Silvani, Robin M. McAllen, Clive N. May, Rohit Ramchandra
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2015)
Article
Physiology
Lindsea C. Booth, Erika E. Nishi, Song T. Yao, Rohit Ramchandra, Gavin W. Lambert, Markus P. Schlaich, Clive N. May
EXPERIMENTAL PHYSIOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Lindsea C. Booth, Markus P. Schlaich, Erika E. Nishi, Song T. Yao, Jianzhong Xu, Rohit Ramchandra, Gavin W. Lambert, Clive N. May
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2015)
Review
Physiology
Rohit Ramchandra, Carolyn J. Barrett
FRONTIERS IN PHYSIOLOGY
(2015)
Editorial Material
Multidisciplinary Sciences
D. Loiselle, R. Ramchandra
ROYAL SOCIETY OPEN SCIENCE
(2015)
Article
Cardiac & Cardiovascular Systems
Davide Martelli, Alessandro Silvani, Robin M. McAllen, Clive N. May, Rohit Ramchandra
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2014)
Article
Physiology
Lindsea C. Booth, Rohit Ramchandra, Paolo Calzavacca, Clive N. May
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2014)
Article
Physiology
Rohit Ramchandra, Sally G. Hood, Clive N. May
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2014)
Article
Physiology
Robert Frithiof, Tao Xing, Michael J. McKinley, Clive N. May, Rohit Ramchandra
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2014)
Article
Critical Care Medicine
Paolo Calzavacca, Michael Bailey, Elena Velkoska, Louise M. Burrell, Rohit Ramchandra, Rinaldo Bellomo, Clive N. May
CRITICAL CARE MEDICINE
(2014)
Article
Peripheral Vascular Disease
Rohit Ramchandra, Song T. Yao, Clive N. May
CURRENT HYPERTENSION REPORTS
(2013)
Article
Physiology
Daniel T. Xing, Clive N. May, Lindsea C. Booth, Rohit Ramchandra
EXPERIMENTAL PHYSIOLOGY
(2014)
Article
Neurosciences
Rohit Ramchandra, Sally G. Hood, Robert Frithiof, Michael J. McKinley, Clive N. May
JOURNAL OF PHYSIOLOGY-LONDON
(2013)
Article
Peripheral Vascular Disease
Lindsea C. Booth, Erika E. Nishi, Song T. Yao, Rohit Ramchandra, Gavin W. Lambert, Markus P. Schlaich, Clive N. May