Twist and Turn—Topoisomerase Functions in Mitochondrial DNA Maintenance

The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis

(2019) S. A. Baechler et al.   Nature Communications

The nature of meiotic chromosome dynamics and recombination in budding yeast

(2019) Soogil Hong et al.   JOURNAL OF MICROBIOLOGY

Known Unknowns of Mammalian Mitochondrial DNA Maintenance

(2018) Jaakko L. O. Pohjoismäki et al.   BIOESSAYS

Mitochondrial tyrosyl‐DNA phosphodiesterase 2 and its TDP2 S short isoform

(2018) Shar‐yin N Huang et al.   EMBO REPORTS

Unveiling the mystery of mitochondrial DNA replication in yeasts

(2018) Xin Jie Chen et al.   MITOCHONDRION

Tissue specific differences in mitochondrial DNA maintenance and expression

(2018) Elena Herbers et al.   MITOCHONDRION

Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA

(2018) Thomas J. Nicholls et al.   MOLECULAR CELL

Mutations in TOP3A Cause a Bloom Syndrome-like Disorder

(2018) Carol-Anne Martin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2

(2018) Anu Hangas et al.   NUCLEIC ACIDS RESEARCH

Dynamic behavior of DNA topoisomerase IIβ in response to DNA double-strand breaks

(2018) Keiko Morotomi-Yano et al.   Scientific Reports

Isobenzofuranone derivative JVPH3, an inhibitor of L. donovani topoisomerase II, disrupts mitochondrial architecture in trypanosomatid parasites

(2018) Somenath Roy Chowdhury et al.   Scientific Reports

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives

(2018) Jessica Marinello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TOP1MT deficiency promotes GC invasion and migration via the enhancements of LDHA expression and aerobic glycolysis

(2017) Hongqiang Wang et al.   ENDOCRINE-RELATED CANCER

The role of mitochondria in cardiac development and protection

(2017) Jaakko L. Pohjoismäki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anthracycline cardiotoxicity: an update on mechanisms, monitoring and prevention

(2017) Peter A Henriksen   HEART

Transcription profiling suggests that mitochondrial topoisomerase IB acts as a topological barrier and regulator of mitochondrial DNA transcription

(2017) Ilaria Dalla Rosa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Recombination and Introgression during Speciation by Hybridization

(2017) Jean-Baptiste Leducq et al.   MOLECULAR BIOLOGY AND EVOLUTION

Plant and Human MORC Proteins Have DNA-Modifying Activities Similar to Type II Topoisomerases, but Require One or More Additional Factors for Full Activity

(2017) Murli Manohar et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Distribution bias and biochemical characterization of TOP1MT single nucleotide variants

(2017) Hongliang Zhang et al.   Scientific Reports

Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA

(2017) Andrea Németh et al.   Scientific Reports

Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans

(2017) Hsin-Yi Yeh et al.   Scientific Reports

MORC Proteins: Novel Players in Plant and Animal Health

(2017) Aline Koch et al.   Frontiers in Plant Science

Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical–induced DNA damage

(2017) Shih-Chieh Chiang et al.   Science Advances

Antileishmanial Mechanism of Diamidines Involves Targeting Kinetoplasts

(2016) Gyongseon Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondrial genome structure of photosynthetic eukaryotes

(2016) N. P. Yurina et al.   BIOCHEMISTRY-MOSCOW

Antibiotic drug levofloxacin inhibits proliferation and induces apoptosis of lung cancer cells through inducing mitochondrial dysfunction and oxidative damage

(2016) Meijun Song et al.   BIOMEDICINE & PHARMACOTHERAPY

p53 as guardian of the mitochondrial genome

(2016) Ji-Hoon Park et al.   FEBS LETTERS

Animal Mitochondrial DNA as We Do Not Know It: mt-Genome Organization and Evolution in Nonbilaterian Lineages

(2016) Dennis V. Lavrov et al.   Genome Biology and Evolution

Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE

(2016) Doyel Sen et al.   NUCLEIC ACIDS RESEARCH

Atypical ploidy cycles, Spo11, and the evolution of meiosis

(2016) Gareth Bloomfield   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

(2016) Afzal Husain et al.   Nature Communications

Potential Therapeutic Advantages of Doxorubicin when Activated by Formaldehyde to Function as a DNA Adduct-Forming Agent

(2015) Suzanne Cutts et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Mitochondrial genome evolution in yeasts: an all-encompassing view

(2015) Kelle C. Freel et al.   FEMS YEAST RESEARCH

Borrowing Nuclear DNA Helicases to Protect Mitochondrial DNA

(2015) Lin Ding et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemotherapy-Induced Cardiotoxicity: Overview of the Roles of Oxidative Stress

(2015) Paweorn Angsutararux et al.   Oxidative Medicine and Cellular Longevity

Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration

(2015) Salim Khiati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms

(2015) Sinem Ilgin et al.   TOXICOLOGY MECHANISMS AND METHODS

The Relationship Between Altered Mitochondrial DNA Copy Number And Cancer Risk: A Meta-Analysis

(2015) Jia Mi et al.   Scientific Reports

Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms

(2015) Sinem Ilgin et al.   TOXICOLOGY MECHANISMS AND METHODS

A Rolling Circle Replication Mechanism Produces Multimeric Lariats of Mitochondrial DNA in Caenorhabditis elegans

(2015) Samantha C. Lewis et al.   PLoS Genetics

An integrated phylogenomic approach toward pinpointing the origin of mitochondria

(2015) Zhang Wang et al.   Scientific Reports

Mitochondrial Topoisomerase I (Top1mt) Is a Novel Limiting Factor of Doxorubicin Cardiotoxicity

(2014) S. Khiati et al.   CLINICAL CANCER RESEARCH

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2)

(2014) Yves Pommier et al.   DNA REPAIR

Mapping Topoisomerase Sites in Mitochondrial DNA with a Poisonous Mitochondrial Topoisomerase I (Top1mt)

(2014) Ilaria Dalla Rosa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minireview: DNA replication in plant mitochondria

(2014) John D. Cupp et al.   MITOCHONDRION

Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases II  and II  in vertebrate mitochondria

(2014) H. Zhang et al.   NUCLEIC ACIDS RESEARCH

The Dissolution of Double Holliday Junctions

(2014) A. H. Bizard et al.   Cold Spring Harbor Perspectives in Biology

Enzymes involved in organellar DNA replication in photosynthetic eukaryotes

(2014) Takashi Moriyama et al.   Frontiers in Plant Science

Relationship of cellular topoisomerase IIα inhibition to cytotoxicity and published genotoxicity of fluoroquinolone antibiotics in V79 cells

(2013) Gary M. Williams et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effect of fluoroquinolones on mitochondrial function in pancreatic beta cells

(2013) Hany Ghaly et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Expression profile and mitochondrial colocalization of Tdp1 in peripheral human tissues

(2013) Hok Khim Fam et al.   JOURNAL OF MOLECULAR HISTOLOGY

Topoisomerases facilitate transcription of long genes linked to autism

(2013) Ian F. King et al.   NATURE

BAF complexes facilitate decatenation of DNA by topoisomerase IIα

(2013) Emily C. Dykhuizen et al.   NATURE

Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation

(2013) Dongyi Xu et al.   NATURE NEUROSCIENCE

Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I

(2013) Stefan Sobek et al.   NUCLEIC ACIDS RESEARCH

Network News: The Replication of Kinetoplast DNA

(2012) Robert E. Jensen et al.   Annual Review of Microbiology

Metabolic regulation of oxygen and redox homeostasis by p53: Lessons from evolutionary biology?

(2012) Jie Zhuang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ciprofloxacin is a potential topoisomerase II inhibitor for the treatment of NSCLC

(2012) TOMASZ KLOSKOWSKI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism

(2012) Céline Douarre et al.   PLoS One

Of circles, forks and humanity: Topological organisation and replication of mammalian mitochondrial DNA

(2011) Jaakko L. O. Pohjoismäki et al.   BIOESSAYS

Evaluating the genotoxicity of topoisomerase-targeted antibiotics

(2011) D. J. Smart et al.   MUTAGENESIS

Evolution of linear chromosomes and multipartite genomes in yeast mitochondria

(2011) Matus Valach et al.   NUCLEIC ACIDS RESEARCH

The RecQ DNA Helicases in DNA Repair

(2010) Kara A. Bernstein et al.   Annual Review of Genetics

Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential, causes mitochondrial peroxynitrite stress in a mouse model of underlying mitochondrial dysfunction

(2010) Chin-Ju J. Hsiao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Safety Considerations of Fluoroquinolones in the Elderly

(2010) Ralf Stahlmann et al.   DRUGS & AGING

Strand Invasion Structures in the Inverted Repeat of Candida albicans Mitochondrial DNA Reveal a Role for Homologous Recombination in Replication

(2010) Joachim M. Gerhold et al.   MOLECULAR CELL

A tyrosyl DNA phosphodiesterase 1 from kinetoplastid parasite Leishmania donovani (LdTdp1) capable of removing topo I-DNA covalent complexes

(2010) Bijoylaxmi Banerjee et al.   MOLECULAR MICROBIOLOGY

Drosophila topo III  is required for the maintenance of mitochondrial genome and male germ-line stem cells

(2010) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria

(2010) B. B. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Heart Mitochondrial DNA Is Organized in Complex Catenated Networks Containing Abundant Four-way Junctions and Replication Forks

(2009) Jaakko L. O. Pohjoismäki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA

(2009) Ilaria Dalla Rosa et al.   NUCLEIC ACIDS RESEARCH

Phylogenomics of DNA topoisomerases: their origin and putative roles in the emergence of modern organisms

(2009) P. Forterre et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial DNA is a direct target of anti-cancer anthracycline drugs

(2008) Neil Ashley et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A fragmented metazoan organellar genome: the two mitochondrial chromosomes of Hydra magnipapillata

(2008) Oliver Voigt et al.   BMC GENOMICS

A new function ofTrypanosoma bruceimitochondrial topoisomerase II is to maintain kinetoplast DNA network topology

(2008) Megan E. Lindsay et al.   MOLECULAR MICROBIOLOGY

Approaches to defining dual-targeted proteins in Arabidopsis

(2008) Chris Carrie et al.   PLANT JOURNAL